PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T16632	Propargyl-PEG4-tetra-Ac-beta-D-galactose	Propargyl-PEG4-tetra-Ac-beta-D-galactose is a PEGylated proteolysis-targeting chimera (PROTAC) linker utilized for PROTAC synthesis[1].
T17012	TCO-amine	TCO-amine is a alkyl chain-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15531	Hydroxy-PEG4-CH2COOH	Hydroxy-PEG4-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14169	Ald-Ph-PEG6-acid	Ald-Ph-PEG6-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17934	endo-BCN-PEG2-C2-NHS ester	endo-BCN-PEG2-C2-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17499	Azido-PEG24-NHS ester	Azido-PEG24-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14421	Azido-PEG2-CH2COOH	Azido-PEG2-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15908	m-PEG7-Boc	m-PEG6-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
T18115	m-PEG-triethoxysilane (MW 2000)	m-PEG-triethoxysilane (MW 2000) is a polyethylene glycol (PEG) based linker compound, specifically designed for the purpose of synthesizing proteolysis-targeting chimeras (PROTACs)[1].
T15327	Fmoc-PEG1-CH2CH2-NHS ester	Fmoc-PEG1-CH2CH2-NHS ester is a polyethylene glycol (PEG) derived linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T17049	Tetraethyl butane-1,4-diylbis(phosphonate)	Tetraethyl butane-1,4-diylbis(phosphonate) is an alkyl chain-derived linker for PROTACs synthesis[1].
T15905	m-PEG6-Amine	m-PEG6-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T18766	TCO-PEG3-Biotin	TCO-PEG3-Biotin is a cleavable ADC linker comprised of three PEG units. It is primarily employed in the synthesis of ADCs, which are antibody-drug conjugates [1].
T14309	APN-C3-PEG4-alkyne	APN-C3-PEG4-alkyne is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18172	m-PEG24-SH	m-PEG24-SH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17128	Tos-PEG3-CH2COOH	Tos-PEG3-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18156	m-PEG16-SH	m-PEG16-SH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18108	m-PEG-thiol (MW 10000)	m-PEG-thiol (MW 10000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18264	Mal-PEG-mal (MW 3400)	Mal-PEG-mal (MW 3400) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15589	Iodo-PEG4-N3	Iodo-PEG4-N3 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

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PROTAC Linker