PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T16201	N-(Biotin)-N-bis(PEG1-alcohol)	N-(Biotin)-N-bis(PEG1-alcohol) is a PEG-based PROTAC linker employed for the synthesis of PROTACs[1].
T17160	Tri(Amino-PEG5-amide)-amine	Tri(Amino-PEG5-amide)-amine is a polyethylene glycol (PEG) derivative serving as a PEG-based proteolysis targeting chimera (PROTAC) linker, facilitating the synthesis of PROTACs[1].
T14228	Amino-PEG2-C2-acid	Amino-PEG2-C2-acid, a cleavable 3-unit PEG ADC linker, is used in the synthesis of antibody-drug conjugates (ADCs) [1].
T14279	Aminooxy-PEG8-methane	Aminooxy-PEG8-methane is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14809	Bromo-PEG5-phosphonic acid diethyl ester	Bromo-PEG5-phosphonic acid diethyl ester is a polyethylene glycol (PEG)-based linker for PROTAC synthesis[1]. It is utilized in the construction of PROteolysis TArgeting Chimeras (PROTACs), which are heterobifunctional molecules designed to induce protein degradation.
T17979	Fmoc-PEG24-NHS ester	Fmoc-PEG24-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18851	Tos-PEG20-Tos	Tos-PEG20-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15967	Mal-C4-NH-Boc	Mal-C4-NH-Boc is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17741	Cys-mcMMAD	Cys-mcMMAD is a drug-linker conjugate for ADC (antibody-drug conjugate) featuring MMAD, a potent tubulin inhibitor.
T17707	C6-Bis-phosphoramidic acid diethyl ester	C6-Bis-phosphoramidic acid diethyl ester is an alkyl chain-derived PROTAC linker suitable for PROTAC synthesis[1].
T14714	Boc-Aminooxy-PEG3-bromide	Boc-Aminooxy-PEG3-bromide is a polyethylene glycol (PEG)-based PROTAC linker utilized in the synthesis of PROTACs, a class of molecules developed for targeted protein degradation[1].
T18649	(±)15-HETE	(±)15-HETE is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
T18785	TCO-PNB ester	TCO-PNB ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17893	cIAP1 Ligand-Linker Conjugates 5	cIAP1 Ligand-Linker Conjugates 5 is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 5, is specifically designed for the development of SNIPERs[1].
T18628	Tos-PEG4-NH-Boc	Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based linker used for the synthesis of PROTACs[1].
T18759	TCO-PEG2-Sulfo-NHS ester	TCO-PEG2-Sulfo-NHS ester is a Polyethylene glycol (PEG)-based linker for PROTAC synthesis[1].
T18375	N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5	N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5 is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimeras (PROTACs) linker, employed for the synthesis of PROTACs[1].
T14622	Bis-Biotin-PEG23	Bis-Biotin-PEG23 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14735	Boc-NH-PEG1-CH2COOH	Boc-NH-PEG1-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17623	Bis-PEG21-acid	Bis-PEG21-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

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PROTAC Linker