PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T14444	Azido-PEG4-Boc	Azido-PEG4-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15906	m-PEG6-amino-Mal	m-PEG6-amino-Mal is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14823	Bromoacetamido-PEG4-acid	Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker utilized for PROTAC synthesis[1]. It also serves as a cleavable 4-unit PEG ADC linker in the synthesis of antibody-drug conjugates (ADCs)[2].
T15850	m-PEG3-aldehyde	m-PEG3-aldehyde is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18496	NHPI-PEG2-C2-NHS ester	NHPI-PEG2-C2-NHS ester is a noncleavable two-unit polyethylene glycol (PEG) linker commonly employed in antibody-drug conjugate (ADC) synthesis.
T18298	Mal-PEG8-alcohol	Mal-PEG8-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14461	Azido-PEG5-CH2CO2H	Azido-PEG5-CH2CO2H is a cleavable 5-unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].
T16970	t-Boc-aminooxy-PEG6-propargyl	t-Boc-aminooxy-PEG6-propargyl is a PEG-based PROTAC linker utilized for PROTAC synthesis[1].
T18045	Hydroxy-PEG7-Boc	Hydroxy-PEG7-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16617	Propargyl-PEG4-beta-D-glucose	Propargyl-PEG4-beta-D-glucose is a polyethylene glycol (PEG) derivatized PROTAC linker employed in the preparation of PROteolysis TArgeting Chimeras (PROTACs)[1].
T16306	NH-bis(PEG4-Boc)	NH-bis(PEG4-Boc) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15882	m-PEG4-O-NHS ester	m-PEG4-O-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18384	N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid	N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a polyethylene glycol (PEG)-based linker for the development of proteolysis targeting chimeras (PROTACs)[1].
T17745	DBCO-C2-PEG4-NH-Boc	DBCO-C2-PEG4-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15854	m-PEG3-Boc	m-PEG3-Boc is a PROTAC linker derived from PEG and alkyl/ether, utilized in the synthesis of PROTACs[1].
T17736	Cy5-PEG5-amine hydrochloride	Cy5-PEG5-amine (hydrochloride) is a PEG-derived PROTAC linker employed for PROTAC synthesis[1].
T17601	Bis(m-PEG4)-N-OH	Bis(m-PEG4)-N-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18715	SPDP-PEG7-acid	SPDP-PEG7-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18168	m-PEG24-Br	m-PEG24-Br is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17849	DSPE-PEG-Amine (MW 5000)	DSPE-PEG-Amine (MW 5000) is a polyethylene glycol (PEG)-based PROTAC linker. It serves as an essential PROTAC linker component in the synthesis of PROteolysis TArgeting Chimeras (PROTACs)[1].

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PROTAC Linker