PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T16062	Methyltetrazine-PEG8-NHS ester	Methyltetrazine-PEG8-NHS ester is a polyethylene glycol (PEG) derivative, specifically designed as a PROTAC linker for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].
T14097	Acid-C2-PEG4-C2-NHS ester	Acid-C2-PEG4-C2-NHS ester, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].
T17154	Tr-PEG8-OH	Tr-PEG8-OH, a non-cleavable 8-unit PEG ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).
T18297	Mal-PEG6-mal	Mal-PEG6-mal is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18731	Sulfo-PDBA-DM4	Sulfo-PDBA-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) applications, combining the potent tubulin inhibitor DM4 with the gluthatione-cleavable linker Sulfo-PDBA. This configuration harnesses DM4's cytotoxic potential through Sulfo-PDBA's targeted delivery mechanism.
T18275	Mal-PEG16-NHS ester	Mal-PEG16-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17374	Ald-Ph-PEG2-Boc	Ald-Ph-PEG2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14020	(2-Pyridyldithio)-PEG4-propargyl	(2-Pyridyldithio)-PEG4-propargyl is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs) [1].
T16318	NH2-PEG8-OH	NH2-PEG8-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18336	Methylcyclopropene-PEG4-NHS	Methylcyclopropene-PEG4-NHS is a four-unit PEG ADC linker, which can be cleaved. It is utilized in the synthesis of antibody-drug conjugates (ADCs)[1].
T16227	N-Mal-N-bis(PEG2-acid)	N-Mal-N-bis(PEG2-acid) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18797	Tetrazine-Ph-NHCO-PEG4-NH-Boc	Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEGylated PROTAC linker suitable for PROTAC synthesis[1].
T17799	DBCO-PEG4-SS-TCO	DBCO-PEG4-SS-TCO is a cleavable 4-unit polyethylene glycol (PEG) linker essential for the synthesis of antibody-drug conjugates (ADCs)[1]. It plays a crucial role in connecting the drug payload to the antibody, enabling targeted drug delivery.
T14648	Bis-PEG7-NHS ester	Bis-PEG7-NHS ester is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) [1].
T18067	Lenalidomide-PEG1-azide	Lenalidomide-PEG1-azide is an E3 ligase ligand-linker conjugate that incorporates the cereblon ligand based on Lenalidomide and a linker. It is designed for use in the development of PROTAC BRD4 Degrader-2[1].
T18241	Mal-amido-PEG24-acid	Mal-amido-PEG24-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18583	Propargyl-PEG4-S-PEG4-acid	Propargyl-PEG4-S-PEG4-acid is a polyethylene glycol (PEG)-based PROTAC linker, suitable for the synthesis of Proteolysis Targeting Chimera (PROTACs)[1].
T17425	Amino-PEG27-amine	Amino-PEG27-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14013	2-(Benzyloxy)ethanol	2-(Benzyloxy)ethanol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18320	MC-Val-Cit-PAB-carfilzomib iodide	MC-Val-Cit-PAB-carfilzomib is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADC), comprising the irreversible proteasome inhibitor carfilzomib, connected through the ADC linker MC-Val-Cit-PAB.

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PROTAC Linker