PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T15969	Mal-N-bis(PEG4-C2-acid)	Mal-N-bis(PEG4-C2-acid) is a polyethylene glycol (PEG) derivative serving as a PEG-based PROTAC linker for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T16969	t-Boc-Aminooxy-PEG3-alcohol	t-Boc-Aminooxy-PEG3-alcohol is a polyethylene glycol (PEG)-based linker compound commonly employed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T18860	Tri-(PEG1-C2-acid)	Tri-(PEG1-C2-acid) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18030	HS-PEG9-CH2CH2COOH	HS-PEG9-CH2CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18713	SPDP-PEG36-NHS ester	SPDP-PEG36-NHS ester is a PEG ADC linker consisting of 36 units, characterized by cleavability. It plays a crucial role in the synthesis of antibody-drug conjugates (ADCs)[1].
T14785	Bromo-PEG1-CH2-Boc	Bromo-PEG1-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15530	Hydroxy-PEG4-CH2-Boc	Hydroxy-PEG4-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15994	Mal-PEG4-Val-Cit-PAB-OH	Mal-PEG4-Val-Cit-PAB-OH, a cleavable 4-unit PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T15970	Mal-NH-Boc	Mal-NH-Boc is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14171	Ald-Ph-amido-PEG2-C2-acid	Ald-Ph-amido-PEG2-C2-acid is a PEG-based PROTAC linker utilized for synthesizing PROTACs[1].
T18747	TAMRA-PEG3-biotin	TAMRA-PEG3-biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18486	NH2-C5-PEG4-N3-L-Lysine-PEG3-N3	NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a seven-unit cleavable polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker employed in the synthesis of ADCs[1].
T15313	Fmoc-NH-PEG1-C2-acid	Fmoc-NH-PEG1-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18733	Sulfo-SPDP-C6-NHS sodium	Sulfo-SPDP-C6-NHS sodium is a sodium salt form of a cleavable ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T13985	1,1,1-Trifluoroethyl-PEG4-alcohol	1,1,1-Trifluoroethyl-PEG4-alcohol is a polyethylene glycol (PEG) derivative commonly employed as a linker in the synthesis of protein degrader molecules, known as PROTACs[1].
T18194	m-PEG36-Mal	m-PEG36-Mal is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18112	m-PEG-Tos (MW 2000)	m-PEG-Tos (MW 2000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14811	Bromo-PEG6-alcohol	Bromo-PEG6-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18843	Thiol-PEG8-alcohol	Thiol-PEG8-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17401	Amino-bis-PEG3-TCO	Amino-bis-PEG3-TCO is a three-unit cleavable polyethylene glycol (PEG) linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].

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PROTAC Linker