PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T18282	Mal-PEG36-NHS ester	Mal-PEG36-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16337	Nonaethylene glycol	Nonaethylene glycol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14721	Boc-Aminooxy-PEG4-Tos	Boc-Aminooxy-PEG4-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15077	DBCO-Sulfo-Link-biotin	DBCO-Sulfo-Link-biotin is a cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs) [1].
T18167	m-PEG24-azide	m-PEG24-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18507	NO2-SPP	NO2-SPP is a cleavable linker used in the synthesis of antibody-drug conjugates (ADC).
T17563	Biotin-PEG2-aldehyde	Biotin-PEG2-aldehyde is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16063	Methyltetrazine-Ph-NHS ester	Methyltetrazine-Ph-NHS ester is an alkyl/ether-based linker utilized for the synthesis of PROTACs, an abbreviation for proteolysis-targeting chimeras[1].
T18255	Mal-NH-PEG14-CH2CH2COOPFP ester	Mal-NH-PEG14-CH2CH2COOPFP ester is a polyethylene glycol-based (PEG) linker for PROteolysis TArgeting Chimeras (PROTACs) [1].
T14828	Bromoacetamido-PEG8-Boc	Bromoacetamido-PEG8-Boc is a PEG-based linker compound utilized for synthesizing PROTACs, which are molecules designed for targeted protein degradation[1].
T18490	NH2-PEG4-Glu(OH)-NH-m-PEG24	NH2-PEG4-Glu(OH)-NH-m-PEG24 is a PEG-based PROTAC linker suitable for PROTAC synthesis[1].
T14158	Ald-CH2-PEG3-CH2-Boc	Ald-CH2-PEG3-CH2-Boc, a PEG- and Alkyl/ether-based PROTAC linker, is utilized for the synthesis of SGK3 kinase PROTAC degrader[1].
T14110	Acid-PEG5-TEMPO	Acid-PEG5-TEMPO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17364	AhR Ligand-Linker Conjugates 1	AhR Ligand-Linker Conjugates 1, also known as E3 Ligase Ligand-Linker Conjugates 57, is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a SNIPER linker. It is specifically designed to be used in the development of SNIPER[1].
T17611	Bis-PEG-TFP ester (MW 5000)	Bis-PEG-TFP ester (MW 5000) is a polyethylene glycol (PEG) based linker compound utilized for synthesizing Proteolysis Targeting Chimeras (PROTACs)[1].
T16638	Propargyl-PEG5-OH	Propargyl-PEG5-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15519	Hydroxy-PEG2-(CH2)2-Boc	Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
T17475	Azido-C3-UV-biotin	Azido-C3-UV-biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14745	Boc-NH-PEG4-C3-acid	Boc-N-amido-PEG4-C3-acid is a polyethylene glycol (PEG) derived linker utilized for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T17641	Boc-aminooxy-amide-PEG4-propargyl	Boc-aminooxy-amide-PEG4-propargyl is a non-cleavable 4-unit polyethylene glycol (PEG) linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1].

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PROTAC Linker