PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T14096	Acid-C2-PEG3-NHS ester	Acid-C2-PEG3-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14254	Amino-PEG9-amine	Amino-PEG9-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17514	Azido-PEG4-nitrile	Azido-PEG4-nitrile is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17710	Carboxyrhodamine 110-PEG4-DBCO	Carboxyrhodamine 110-PEG4-DBCO is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].
T17533	BCN-PEG4-acid	BCN-PEG4-acid is a cleavable four-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T18354	Methyltetrazine-PEG5-triethoxysilane	Methyltetrazine-PEG5-triethoxysilane is a polyethylene glycol (PEG)-based PROTAC linker suitable for PROTAC synthesis[1].
T18659	S-Bis-(PEG4-Boc)	S-Bis-(PEG4-Boc) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17773	DBCO-NHCO-PEG7-acid	DBCO-NHCO-PEG7-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18052	Iodoacetamide-PEG3-azide	Iodoacetamide-PEG3-azide is a PEG-derived PROTAC linker utilized for synthesizing PROTACs. [1]
T18245	Mal-C2-cyclohexylcarboxyl-hydrazide TFA	Mal-C2-cyclohexylcarboxyl-hydrazide TFA is a alkyl chain-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14261	Aminooxy-PEG2-alcohol	Aminooxy-PEG2-alcohol is a non-cleavable PEG linker consisting of two units, utilized in the synthesis of antibody-drug conjugates (ADCs) [1]. This compound serves as a PEG-based PROTAC linker for the synthesis of PROTACs as well [2].
T14806	Bromo-PEG5-Boc	Bromo-PEG5-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18642	PTAD-PEG4-alkyne	PTAD-PEG4-alkyne is a four-unit polyethylene glycol (PEG) linker compound, employed in the synthesis of antibody-drug conjugates (ADCs)[1]. It is cleavable and serves as a connecting structure between the antibody and the drug, facilitating targeted drug delivery.
T18407	N-Boc-PEG9-alcohol	N-Boc-PEG9-alcohol is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) [1].
T17342	6-O-2-Propyn-1-yl-D-galactose	6-O-2-Propyn-1-yl-D-galactose functions as an irreversible glycolinker, facilitating the attachment of cytotoxic drugs for applications in antibody-drug conjugation.
T18083	m-PEG-azide (MW 2000)	m-PEG-azide (MW 2000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14265	Aminooxy-PEG3-bromide	Aminooxy-PEG3-bromide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14773	Br-PEG4-OH	Br-PEG4-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14162	Ald-Ph-amido-C2-PEG2-amine	Ald-Ph-amido-C2-PEG2-amine is a polyethylene glycol (PEG)-based linker utilized for the synthesis of PROteolysis TArgeting Chimeras (PROTACs)[1].
T18752	TCO-PEG-TCO (MW 5000)	TCO-PEG-TCO (MW 5000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

注册成功

PROTAC Linker