PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T18804	Tetrazine-SS-PEG4-Biotin	Tetrazine-SS-PEG4-Biotin, a cleavable 4-unit PEG ADC linker, is employed for the synthesis of antibody-drug conjugates (ADCs)[1].
T16826	S-acetyl-PEG6-Boc	S-acetyl-PEG6-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18798	Tetrazine-Ph-NHCO-PEG6-NH-Boc	Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker utilized for PROTACs synthesis[1].
T14649	Bis-PEG7-PFP ester	Bis-PEG7-PFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18369	N-(5-Hydroxypentyl)maleimide	N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs). It serves as a crucial component in the production of Gemcitabine-O-Si(di-iso)-O-Mc, an ADC compound [1].
T14470	Azido-PEG6-NHS ester	Azido-PEG6-NHS ester is a cleavable 6 unit polyethylene glycol (PEG) linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, it serves as a PEG- and alkyl/ether based linker for the synthesis of proteolysis targeting chimeras (PROTACs)[2].
T14443	Azido-PEG4-beta-D-glucose	Azido-PEG4-beta-D-glucose is a polyethylene glycol (PEG)-based linker compound essential for the efficient synthesis of proteolysis targeting chimeras (PROTACs)[1].
T16178	N-(Azido-PEG2)-N-Boc-PEG3-Boc	N-(Azido-PEG2)-N-Boc-PEG3-Boc is a PEG-based PROTAC linker, suitable for the synthesis of PROTACs[1].
T17461	Azide-PEG-azide (MW 2000)	Azide-PEG-azide (MW 2000) is a polyethylene glycol (PEG)-based linker utilized for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T17621	Bis-PEG17-acid	Bis-PEG17-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17393	Amine-PEG-amine (MW 35000)	Amine-PEG-amine (MW 35000), a PEG-based PROTAC linker, is utilized for the synthesis of PROTACs[1].
T17914	Thalidomide-O-amido-C3-COOH	Thalidomide-O-amido-C3-COOH is a synthesized conjugate of an E3 ligase ligand-linker compound that combines a cereblon ligand derived from Thalidomide with a linker commonly employed in PROTAC technology.
T15927	m-PEG8-Amine	m-PEG8-Amine is a cleavable linker vital in ADC synthesis. m-PEG8-Amine joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.
T14753	Boc-NH-PEG6-propargyl	Boc-NH-PEG6-propargyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17925	(S,R,S)-AHPC-PEG2-NH2	(S,R,S)-AHPC-PEG2-NH2 (VHL Ligand-Linker Conjugates 3) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。可用于 PROTAC 的合成分子。
T16193	N-(Azido-PEG3)-NH-PEG3-acid	N-(Azido-PEG3)-NH-PEG3-acid is a polyethylene glycol (PEG) derived linker utilized for the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T17885	cIAP1 Ligand-Linker Conjugates 11	cIAP1 Ligand-Linker Conjugates 11 is a chemical compound that combines an IAP ligand specifically designed for the E3 ubiquitin ligase with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 11, is useful in the development of SNIPERs[1], allowing for the targeted degradation of proteins.
T18373	N-(Amino-PEG4)-N-Biotin-PEG4-acid	N-(Amino-PEG4)-N-Biotin-PEG4-acid is a PEG-based PROTAC linker that incorporates biotin for labeling purposes. This compound serves as a versatile tool in the synthesis of PROTACs[1].
T14028	3,6,9-Trioxaundecanedioic Acid	369-Trioxaundecanedioic Acid, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].
T17908	VHL Ligand-Linker Conjugates 15	VHL Ligand-Linker Conjugates 15 is a chemical compound that combines a VHL ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is specifically designed for the creation of PROTACs[1].

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PROTAC Linker