PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T18146	m-PEG13-Hydrazide	m-PEG13-Hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14252	Amino-PEG8-hydrazide-Boc	Amino-PEG8-hydrazide-Boc is a PEG-conjugated hydrazide linker employed in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T17774	DBCO-NHCO-S-S-NHS ester	DBCO-NHCO-S-S-NHS ester is a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].
T18351	Methyltetrazine-PEG4-SS-NHS ester	Methyltetrazine-PEG4-SS-NHS ester is a cleavable, four-unit polyethylene glycol (PEG) linker commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T14426	Azido-PEG3-C-Boc	Azido-PEG3-C-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17669	Boc-NH-PEG12-propargyl	Boc-NH-PEG12-propargyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17418	Amino-PEG23-acid	Amino-PEG23-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17368	Ald-Ph-amido-C2-PEG3-azide	Ald-Ph-amido-C2-PEG3-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15119	Diethoxy-phosphorylethyl-PEG5-ethylphosphonic acid	Diethoxy-phosphorylethyl-PEG5-ethylphosphonic acid is a polyethylene glycol (PEG) derived linker that is employed in PROTAC synthesis[1].
T18423	N-(m-PEG4)-N'-(azide-PEG3)-Cy5	N-(m-PEG4)-N'-(azide-PEG3)-Cy5 is a polyethylene glycol (PEG)-based linker utilized for the synthesis of protein degraders, known as PROTACs[1].
T16586	Propargyl-PEG1-NH2	Propargyl-PEG1-NH2, a PEG-based PROTAC linker, can be utilized in the synthesis of PROTACs[1].
T17969	Fmoc-NH-PEG16-CH2CH2COOH	Fmoc-NH-PEG16-CH2CH2COOH is a polyethylene glycol (PEG)-based linker, specifically designed for use in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T17511	Azido-PEG36-alcohol	Azido-PEG36-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17086	THP-PEG8-Tos	THP-PEG8-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18830	Thalidomide-O-PEG4-NHS ester	Thalidomide-O-PEG4-NHS ester is a polyethylene glycol (PEG)-based linker, commonly employed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T14717	Boc-Aminooxy-PEG4-azide	Boc-Aminooxy-PEG4-azide is a polyethylene glycol (PEG) derived linker with potential applications in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T16880	SIA Crosslinker	SIA Crosslinker is a non-cleavable ADC linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1].
T17810	DBCO-PEG9-NH-Boc	DBCO-PEG9-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15890	m-PEG5-Boc	m-PEG5-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16212	N-Boc-PEG3-bromide	N-Boc-PEG3-bromide, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

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PROTAC Linker