PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T17602	Bis-(m-PEG8-amido)-hexanoic acid	Bis-(m-PEG8-amido)-hexanoic acid is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs) [1].
T18008	HO-PEG12-CH2COOH	HO-PEG12-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16215	N-Boc-PEG4-bromide	N-Boc-PEG4-bromide is a cleavable ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T18127	m-PEG11-Hydrazide	m-PEG11-Hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T13999	(10-BRomodecyl)phosphonic acid	(10-BRomodecyl)phosphonic acid is an alkyl chain-derived PROTAC linker suitable for PROTAC synthesis [1].
T17552	Biotin-PEG-Biotin (MW 1000)	Biotin-PEG-Biotin (MW 1000) is a PEG-derived PROTAC linker employed in PROTAC synthesis[1].
T18339	Methyltetrazine-PEG13-acid	Methyltetrazine-PEG13-acid is a PEGylated linker derived from PEG that serves as a valuable component in the production of PROTACs, a class of compounds known for their targeted protein degradation properties[1].
T17053	Tetraethyl octane-1,8-diylbis(phosphonate)	Tetraethyl octane-1,8-diylbis(phosphonate) is an alkyl chain-based linker compound employed in PROTAC synthesis[1].
T18618	Bis-NH2-C1-PEG3	Bis-NH2-C1-PEG3 (PROTAC Linker 24) is a polyethylene glycol (PEG)-based linker compound utilized in the synthesis of PROTACs. This compound serves as a critical component in constructing PROTAC molecules, facilitating the targeted degradation of specific proteins[1].
T14647	Bis-PEG7-acid	Bis-PEG7-acid and bis-PEG6-propionic acid are chemical compounds that serve as linkers in the synthesis of PROTACs and antibody-drug conjugates (ADCs), respectively. Bis-PEG7-acid is a PEG-based PROTAC linker, while bis-PEG6-propionic acid is a cleavable ADC linker[1].
T18324	MC-Val-Cit-PAB-duocarmycin chloride	MC-Val-Cit-PAB-duocarmycin is an antibody-drug conjugate (ADC) linker that combines duocarmycin, a potent DNA minor groove-binding alkylating agent, with an antitumor drug through the MC-Val-Cit-PAB linker, exhibiting significant antitumor activity.
T15161	Doxorubicin-SMCC	Doxorubicin-SMCC is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T17633	Bis-propargyl-PEG11	Bis-propargyl-PEG11 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15504	HS-PEG6-CH2CH2-Boc	HS-PEG6-CH2CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15490	HO-PEG15-OH	HO-PEG15-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17917	Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2	Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized conjugate compound known as an E3 ligase ligand-linker. It incorporates a cereblon ligand based on Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology applications.
T17789	DBCO-(PEG2-VC-PAB-MMAE)2	DBCO-(PEG2-VC-PAB-MMAE)2 consists of Monomethyl auristatin E (MMAE), a toxin payload in antibody-drug conjugate [1], conjugated to the cleavable linker DBCO-(PEG2-VC-PAB)2. MMAE, a potent tubulin inhibitor, serves as the cytotoxic component in this formulation.
T17489	Azido-PEG16-acid	Azido-PEG16-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17046	Tetra(cyanoethoxymethyl) methane	Tetra(cyanoethoxymethyl) methane is an alkyl chain-derived PROTAC linker suitable for synthesizing PROTACs[1].
T18436	N-(m-PEG4)-N'-(PEG4-acid)-Cy5	N-(m-PEG4)-N'-(PEG4-acid)-Cy5 is a polyethylene glycol (PEG)-based PROTAC linker employed for PROTACs[1] synthesis.

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PROTAC Linker