PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T18442	N-Me-N-bis(PEG4-acid)	N-Me-N-bis(PEG4-acid) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17764	DBCO-NHCO-PEG2-Biotin	DBCO-NHCO-PEG2-Biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14484	Azidoethyl-SS-ethylamine	Azidoethyl-SS-ethylamine is a cleavable linker compound employed for the synthesis of antibody-drug conjugates (ADCs)[1].
T18844	Thiol-PEG9-alcohol	Thiol-PEG9-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16821	S-acetyl-PEG3-Boc	S-acetyl-PEG3-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17469	Azide-PEG3-Sulfone-PEG3-azide	Azide-PEG3-Sulfone-PEG3-azide is a polyethylene glycol (PEG)-based bifunctional molecule, specifically designed as a PROTAC linker for the synthesis of PROTACs[1].
T14237	Amino-PEG4-alcohol	Amino-PEG4-alcohol is a PEG-based PROTAC linker that can be employed for the synthesis of PROTACs[1]. It is also a non-cleavable 4 unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[2].
T15290	Fluorescein-DBCO	Fluorescein-DBCO is a non-cleavable linker employed for synthesizing antibody-drug conjugates (ADCs) [1].
T16620	Propargyl-PEG5-acid	Propargyl-PEG5-acid is a non-cleavable 5-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and can be employed to create ADC inhibitors of Galectin-3 [1].
T15120	Diethyl 10-bromodecylphosphonate	Diethyl 10-bromodecylphosphonate is an alkyl-based PROTAC linker utilized for the synthesis of PROTACs[1].
T16181	N-(Azido-PEG2)-N-Boc-PEG4-Boc	N-(Azido-PEG2)-N-Boc-PEG4-Boc is a PEG-based bifunctional linker employed for the synthesis of PROTACs.
T14056	6-Bromohexylphosphonic acid	6-Bromohexylphosphonic acid is an alkyl chain-based linker commonly employed in the synthesis of PROTACs, which stands for proteolysis targeting chimeras[1].
T17361	Acrylate-PEG-OH (MW 3400)	Acrylate-PEG-OH (MW 3400) is a polyethylene glycol (PEG) derived PROTAC linker compound, which finds application in the synthesis of PROTACs[1].
T14581	Biotin-PEG12-acid	Biotin-PEG12-acid is a PEG-based PROTAC linker labeled with biotin, designed for synthesis of PROTACs[1].
T14275	Aminooxy-PEG4-propargyl	Aminooxy-PEG4-propargyl is a PEG-based PROTAC linker for the synthesis of PROTACs[1].
T18848	Tos-PEG12-Tos	Tos-PEG12-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15858	m-PEG3-CH2COOH	m-PEG3-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16635	Propargyl-PEG4-Tos	Propargyl-PEG4-Tos is a PEG-based PROTAC linker utilized for the synthesis of PROTACs and cleavable ADC linkers in antibody-drug conjugate (ADC) synthesis [1][2].
T15845	m-PEG2-CH2CH2COOH	m-PEG2-CH2CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18802	Tetrazine-SS-Biotin	Tetrazine-SS-Biotin, a cleavable ADC linker, finds utility in ADC (antibody-drug conjugate) synthesis [1].

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PROTAC Linker