PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T18199	m-PEG37-Propargyl	m-PEG37-Propargyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18110	m-PEG-thiol (MW 20000)	m-PEG-thiol (MW 20000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15926	m-PEG7-Tos	m-PEG7-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17316	α-Lipoic acid-NHS	α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs [1].
T18207	m-PEG49-acid	m-PEG49-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17973	Fmoc-NH-PEG30-CH2CH2COOH	Fmoc-NH-PEG30-CH2CH2COOH is a PEGylation-based PROTAC linker employed for the synthesis of PROTACs[1].
T14406	Azido-PEG1-C2-methylamine	Azido-PEG1-C2-methylamine is a PEG-conjugated linker employed in the synthesis of PROTACs[1].
T17080	Thiol-PEG8-acid	Thiol-PEG8-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17362	Acrylate-PEG-OH (MW 5000)	Acrylate-PEG-OH (MW 5000) is a Polyethylene Glycol (PEG)-based linker compound primarily utilized in PROTAC synthesis[1].
T18224	m-PEG9-Boc	m-PEG9-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18209	m-PEG5-Hydrazide	m-PEG5-Hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17120	Tos-PEG2-Boc	Tos-PEG2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16917	SPDP-PEG4-NHS ester	SPDP-PEG4-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17516	Azido-PEG5-maleimide	Azido-PEG5-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18314	MC-PEG2-C2-NHS ester	MC-PEG2-C2-NHS ester, a noncleavable 2-unit polyethylene glycol (PEG) linker, is employed in the synthesis of antibody-drug conjugates (ADCs).
T18677	SC-Val-Cit-PAB	SC-Val-Cit-PAB is a cleavable ADC linker for antibody-drug conjugates (ADCs).
T18587	Propargyl-PEG4-Sulfone-PEG4-Boc	Propargyl-PEG4-Sulfone-PEG4-Boc is a polyethylene glycol (PEG)-based linker molecule for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T16590	Propargyl-PEG1-SS-PEG1-C2-Boc	Propargyl-PEG1-SS-PEG1-C2-Boc is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].
T17749	DBCO-mPEG (MW 10kDa)	DBCO-mPEG (MW 10kDa) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16657	Boc-NH-PEG2	Boc-NH-PEG2 (PROTAC Linker 11) is a polyethylene glycol (PEG)-based linker that finds application in the synthesis of PROTACs. [1]

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PROTAC Linker