PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T17078	Thiol-PEG4-Boc	Thiol-PEG4-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17542	Benzyl-N-bis(PEG3-Boc)	Benzyl-N-bis(PEG3-Boc) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17782	DBCO-PEG12-acid	DBCO-PEG12-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16602	Propargyl-PEG2-NHBoc	Propargyl-PEG2-NHBoc is a cleavable ADC linker utilized for the synthesis of antibody-drug conjugates (ADCs). This PEG-based PROTAC linker, namely Propargyl-PEG2-NHBoc, holds potential for the synthesis of PROTACs[1].
T17079	Thiol-PEG6-alcohol	Thiol-PEG6-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14486	Azidoethyl-SS-PEG2-Boc	Azidoethyl-SS-PEG2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16640	Propargyl-PEG6-alcohol	Propargyl-PEG6-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs[1].
T15893	m-PEG5-CH2COOH	m-PEG5-CH2COOH is a non-cleavable ADC linker employed in the synthesis of antibody-drug conjugates (ADCs).
T16244	N-(PEG2-C2-acid)-N-bis(PEG2-propargyl)	N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a polyethylene glycol (PEG)-based linker compound designed for the synthesis of PROTACs[1].
T16458	PEG4-bis(phosphonic acid diethyl ester)	PEG4-bis(phosphonic acid diethyl ester) is a polyethylene glycol (PEG) derivative serving as a linker for PROTAC synthesis. It is specifically designed for the creation of proteolysis-targeting chimeras (PROTACs)[1].
T18622	BnOH-NH-bis-(C2-S)-propane-O-isoprene ester	BnOH-NH-bis-(C2-S)-propane-O-isoprene ester (PROTAC Linker 29) is an alkyl ether-based linker primarily utilized in the synthesis of PROTACs.
T17329	2-Bromo-2,2-dimethyl-acetamido-PEG3-acid	2-Bromo-22-dimethyl-acetamido-PEG3-acid is a polyethylene glycol (PEG) derivative commonly employed as a PEG-based PROTAC linker during PROTAC synthesis[1].
T17801	DBCO-PEG4-VA-PBD	DBCO-PEG4-VA-PBD is a cleavable 4-unit PEG ADC linker utilized in antibody-drug conjugate (ADC) synthesis [1].
T17860	DSPE-PEG46-DBCO	DSPE-PEG46-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18443	N-Me-N-bis(PEG4-C2-Boc)	N-Me-N-bis(PEG4-C2-Boc) is a PROTAC linker utilizing alkyl and ether functionalities, which is instrumental in PROTAC synthesis. [1]
T18158	m-PEG17-Hydrazide	m-PEG17-Hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18198	m-PEG37-NHS ester	m-PEG37-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16651	Propargyl-PEG8-NH2	Propargyl-PEG8-NH2 (compound 3b) is a non-cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].
T17083	THP-PEG5-OH	THP-PEG5-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17451	APN-PEG4-DBCO	APN-PEG4-DBCO is a cleavable linker for antibody-drug conjugates (ADCs), comprised of a four-unit PEG and a DBCO moiety. It finds application in the synthesis of ADCs[1].

注册成功

PROTAC Linker