PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T18227	m-PEG9-Hydrazide	m-PEG9-Hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17676	Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA	Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA is a double-cleavable PEG linker (3-unit and 4-unit) designed for antibody-drug conjugation (ADC).
T14618	Bis-aminooxy-PEG2	Bis-aminooxy-PEG2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18289	Mal-PEG4-VA-PBD	Mal-PEG4-VA-PBD is a drug-linker conjugate for Antibody-Drug Conjugates (ADCs), comprising the antitumor antibiotic Pyrrolobenzodiazepine (PBD), connected through Mal-PEG4-VA.
T15848	m-PEG2-Tos	m-PEG2-Tos is an uncleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).
T17980	Fmoc-Phe-Lys(Trt)-PAB-PNP	Fmoc-Phe-Lys(Trt)-PAB-PNP is a cleavable linker for antibody-drug conjugate (ADC) synthesis, specifically designed for use in ADC synthesis.
T17013	TCO-C3-PEG3-C3-amine	TCO-C3-PEG3-C3-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18248	Mal-C2-NHS ester	Mal-C2-NHS ester is a noncleavable linker compound commonly employed for the synthesis of antibody-drug conjugates (ADCs)[1].
T18450	N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3	N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a polyethylene glycol (PEG)-based linker used for the synthesis of proteolysis targeting chimeras (PROTACs) [1].
T17153	Tr-PEG6-OH	Tr-PEG6-OH is a 6-unit polyethylene glycol (PEG) linker, which is non-cleavable and extensively employed in the synthesis of antibody-drug conjugates (ADCs).
T15068	DBCO-PEG4-amine	DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker)[1].
T14752	Boc-NH-PEG6-CH2CH2COOH	Boc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker employed in antibody-drug conjugates (ADC).
T16467	Pentaethylene glycol monomethyl ether	Pentaethylene glycol monomethyl ether (PEG-MME) is a PEG-based PROTAC linker, which is employed for the synthesis of PROTACs[1].
T16308	NH-bis-PEG4	NH-bis-PEG4 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16196	N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester)	N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a polyethylene glycol (PEG)-based linker employed in the synthesis of proteolysis-targeting chimeras (PROTACs).
T14952	Chloroacetamido-PEG4-C2-Boc	Chloroacetamido-PEG4-C2-Boc is a PEG-based PROTAC linker that incorporates alkyl and ether functionalities. This compound is utilized in synthesizing PROTACs, offering a versatile platform for targeted protein degradation.
T18163	m-PEG23-alcohol	m-PEG23-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18464	N-(Tos-PEG4)-N-bis(PEG4-Boc)	N-(Tos-PEG4)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1].
T17596	Biotin-PEG8-NHS ester	Biotin-PEG8-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18028	HS-PEG7-CH2CH2N3	HS-PEG7-CH2CH2N3 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

注册成功

PROTAC Linker