PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T15086	Dde Biotin-PEG4-Picolyl azide	Dde Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker used for synthesizing PROTACs[1].
T18556	Pomalidomide-PEG4-azide	Pomalidomide-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
T17815	DBCO-Val-Cit-PABC-OH	DBCO-Val-Cit-PABC-OH is a cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs) [1].
T14519	BDP FL-PEG5-azide	BDP FL-PEG5-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15521	Hydroxy-PEG2-CH2COOH	Hydroxy-PEG2-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14427	Azido-PEG3-C3-OH	Azido-PEG3-C3-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17564	Biotin-PEG2-C1-aldehyde	Biotin-PEG2-C1-aldehyde is a polyethylene glycol (PEG)-based linker utilized in synthesizing proteolysis targeting chimeras (PROTACs) [1].
T15314	Fmoc-NH-PEG1-CH2COOH	Fmoc-NH-PEG1-CH2COOH is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].
T17932	endo-BCN-PEG12-acid	endo-BCN-PEG12-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17721	Cbz-NH-PEG24-C2-acid	Cbz-NH-PEG24-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17335	4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid	4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable linker compound employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T17546	Biotin-C1-PEG3-C3-amine TFA	Biotin-C1-PEG3-C3-amine (TFA) is a polyethylene glycol (PEG) based linker that serves as a crucial component in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T15834	m-PEG10-alcohol	m-PEG10-alcohol, also known as Decaethylene glycol monomethyl ether, is a non-cleavable 10 unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, m-PEG10-alcohol serves as a PEG-based PROTAC linker, enabling its application in the synthesis of PROTACs[1].
T14428	Azido-PEG3-CH2CO2Me	Azido-PEG3-CH2CO2Me is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17954	Fmoc-Lys (biotin-PEG12)-OH	Fmoc-Lys (biotin-PEG12)-OH is a PEGylation-based linker compound utilized in PROTAC synthesis[1].
T17626	Bis-PEG25-acid	Bis-PEG25-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17531	BCN-PEG3-Val-Cit	BCN-PEG3-Val-Cit is a PEG-based linker commonly employed in PROTAC synthesis[1]. Additionally, it serves as a cleavable 3 unit PEG linker in the production of antibody-drug conjugates (ADCs)[2].
T17826	Diketone-PEG12-Biotin	Diketone-PEG12-Biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17126	Tos-PEG4-acid	Tos-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17972	Fmoc-NH-PEG3-C2-NH2	Fmoc-NH-PEG3-C2-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

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PROTAC Linker