酪氨酸激酶分子库

Tyrosine Kinase Inhibitor Library

产品编号： L2200

蛋白激酶（PK）是正常细胞信号转导的重要介质，通过对底物蛋白的磷酸化来调节它们的活性、定位和整体功能。蛋白激酶参与几乎所有细胞过程的活动，在细胞增殖、血管生成、迁移、细胞周期等过程中发挥关键作用。在众多蛋白激酶中，酪氨酸蛋白激酶(TK)可能是癌症治疗较有吸引力的靶点，因为TK 信号异常通常与肿瘤发生发展密切相关，此外，TK 在炎症和类风湿性关节炎等其他疾病中也起着关键作用。

TargetMol 酪氨酸激酶分子库精选 1016 种酪氨酸激酶抑制剂，用于研究酪氨酸激酶相关的疾病和药物，可用于高通量筛选和高内涵筛选。

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产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

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产品描述

1016种酪氨酸激酶抑制剂的独特集合，可用于高通量筛选和高内涵筛选；
靶点含c-kit、c-Met、EGFR、FGFR、SRC、JAK、SYK、Btk、Bcr-Abl等；
通过临床前研究和临床实验，生物活性和安全性已经得到验证，部分产品已被FDA批准上市；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

EGFR (181)

VEGFR (155)

Apoptosis (108)

FLT (100)

Src (99)

PDGFR (89)

FGFR (79)

c-Kit (76)

Autophagy (72)

Bcr-Abl (69)

c-Met/HGFR (67)

ALK (63)

BTK (59)

JAK (50)

HER (49)

Tyrosine Kinases (48)

PKA (45)

CDK (40)

IGF-1R (37)

c-RET (36)

TAM Receptor (34)

Trk receptor (32)

FAK (31)

c-Fms (30)

Aurora Kinase (26)

Syk (24)

Raf (23)

DYRK (20)

TGF-beta/Smad (20)

Akt (18)

PKC (17)

Ephrin Receptor (16)

ROS Kinase (16)

CSF-1R (14)

Discoidin Domain Receptor (DDR) (12)

S6 Kinase (12)

GSK-3 (11)

ERK (9)

p38 MAPK (8)

PI3K (8)

Tie-2 (8)

Calcium Channel (8)

ROS (8)

5-HT Receptor (8)

Potassium Channel (8)

Ferroptosis (7)

PYK2 (7)

ROCK (7)

Chk (7)

mTOR (7)

Serine/threonin kinase (6)

MEK (6)

Microtubule Associated (6)

Drug Metabolite (5)

ACK (5)

Casein Kinase (5)

MLK (5)

PROTACs (4)

Histamine Receptor (4)

JNK (4)

Pim (4)

RIP kinase (4)

MAPK (4)

IκB/IKK (4)

STAT (4)

P450 (4)

SGK (4)

AChR (4)

Sodium Channel (4)

Tyrosinase (4)

Ligands for Target Protein for PROTAC (3)

Mitophagy (3)

Hck (3)

CaMK (3)

DNA/RNA Synthesis (3)

SARS-CoV (3)

HDAC (3)

AMPK (3)

PLK (3)

HIV Protease (2)

HCV Protease (2)

Dehydrogenase (2)

Phosphatase (2)

Adrenergic Receptor (2)

IRE1 (2)

Myosin (2)

PDE (2)

GRK (2)

MMP (2)

Antibacterial (2)

Interleukin (2)

MNK (2)

Antiviral (2)

HSP (2)

Influenza Virus (2)

Beta Amyloid (2)

Endogenous Metabolite (2)

PDK (2)

Phospholipase (2)

IGF-2R (2)

IRAK (2)

Sigma receptor (2)

Antibiotic (2)

Melanin-concentrating Hormone Receptor (MCHR) (1)

DHFR (1)

ROR (1)

Histone Methyltransferase (1)

DNA-PK (1)

Integrin (1)

YAP (1)

Antifungal (1)

Antioxidant (1)

Adenosine Receptor (1)

Na+/Ca2+ Exchanger (1)

IFNAR (1)

NADPH (1)

GTPase (1)

Virus Protease (1)

Rho (1)

Antifolate (1)

Serine Protease (1)

Serotonin Transporter (1)

NAMPT (1)

Caspase (1)

MAO (1)

E1/E2/E3 Enzyme (1)

Haspin Kinase (1)

LDL (1)

NMDAR (1)

Mitochondrial Metabolism (1)

Monoamine Transporter (1)

Reactive Oxygen Species (1)

DNA Alkylation (1)

IL Receptor (1)

CCR (1)

GluR (1)

Epigenetic Reader Domain (1)

Norepinephrine (1)

DUB (1)

BCRP (1)

P-gp (1)

LRRK2 (1)

Sirtuin (1)

Histone Acetyltransferase (1)

PAI-1 (1)

MELK (1)

RSV (1)

Hippo pathway (1)

Reverse Transcriptase (1)

Protease (1)

CRISPR/Cas9 (1)

GPR (1)

HIF (1)

TNF (1)

DAPK (1)

Gap Junction Protein (1)

p97 (1)

HIF/HIF Prolyl-Hydroxylase (1)

p53 (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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