抗癌细胞代谢库

Anti-Cancer Metabolism Compound Library

产品编号： L2130

肿瘤的代谢异常已成为肿瘤学研究的热点，细胞代谢的重编程对于癌细胞维持生存和无限增殖至关重要。从德国科学家Warburg 发现肿瘤细胞存在有氧糖酵解的现象到如今对肿瘤代谢活动的各个方面(糖、脂肪、氨基酸等)的解析和复杂代谢调控网络的发现, 肿瘤代谢的研究进入了更加引人注目的高地。因此，肿瘤细胞异常的代谢通路(如葡萄糖和谷氨酰胺代谢途径)、关键代谢调控因子(如cMYC、HIF、p53)及代谢酶(如PKM、IDH、GLS)可能是肿瘤治疗的关键靶点。针对肿瘤细胞代谢改变的重要特征及其分子机制, 研制出针对特定代谢通路或特定代谢酶的高效抗肿瘤药物, 从而用于临床治疗一直是肿瘤代谢研究的目标和追求。

我们根据相关文献报道筛选了多种肿瘤代谢相关的生物活性小分子组成抗癌细胞代谢库，是进行抗肿瘤药物筛选的理想工具。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

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陶术生物化合物库目录(2.8MB)

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产品描述

1268种癌细胞代谢相关的生物活性小分子化合物的特有集合，用于肿瘤相关的研究以及抗肿瘤药物的筛选，用于高通量、高内涵筛选；
产品经过临床验证或临床前实验，具有生物安全保障和一定的生物活性；
是肿瘤发生机理研究、抗肿瘤药物筛选的有效工具；
靶点包含16个与癌细胞糖类、脂质、氨基酸和核苷酸代谢相关靶点，如ACL、CA、FASN、GLUT、GLS、HMG-CoA、MAGL、MCTs、PDH、PDK、 PKM等等；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS检测技术保证产品高纯度和高质量，减少假阳性发生概率。

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化合物库组成

Apoptosis (217)

PI3K (188)

Autophagy (175)

Dehydrogenase (142)

mTOR (98)

Akt (93)

Src (91)

Wnt/beta-catenin (87)

STAT (85)

AMPK (76)

Bcr-Abl (62)

Ras (61)

GSK-3 (57)

CDK (43)

Endogenous Metabolite (42)

p53 (42)

Antibacterial (40)

NF-κB (37)

HIF/HIF Prolyl-Hydroxylase (37)

Carbonic Anhydrase (36)

DNA-PK (36)

S6 Kinase (31)

HIF (29)

VEGFR (27)

Fatty Acid Synthase (26)

JAK (25)

Indoleamine 2,3-Dioxygenase (IDO) (23)

ERK (22)

Reactive Oxygen Species (22)

ATM/ATR (22)

HMG-CoA Reductase (22)

Glucokinase (21)

FLT (21)

c-Kit (21)

Raf (20)

Parasite (20)

PDGFR (20)

PDK (20)

Antibiotic (20)

Mdm2 (19)

p38 MAPK (19)

Aurora Kinase (17)

DNA/RNA Synthesis (17)

transporter (17)

FGFR (16)

c-Myc (15)

Ferroptosis (15)

E1/E2/E3 Enzyme (15)

EGFR (14)

PKA (13)

PARP (13)

Rho (13)

PI4K (12)

HIV Protease (11)

JNK (11)

Mitophagy (11)

Caspase (11)

IDO (11)

PKC (11)

Isocitrate Dehydrogenase (IDH) (11)

MAPK (11)

MEK (11)

PPAR (10)

IL Receptor (10)

IGF-1R (10)

P450 (10)

TNF (10)

Calcium Channel (9)

ROCK (9)

COX (9)

Potassium Channel (9)

Casein Kinase (9)

Antifungal (8)

Virus Protease (8)

BCL (8)

Chk (8)

c-RET (8)

FAK (8)

Phosphatase (7)

Stearoyl-CoA Desaturase (SCD) (7)

MMP (7)

Interleukin (7)

Influenza Virus (7)

PKM (7)

HCV Protease (6)

c-Met/HGFR (6)

PDE (6)

Mitochondrial Metabolism (6)

Glutaminase (6)

Sirtuin (6)

MAGL (6)

PTEN (6)

c-Fms (6)

AChR (6)

Microtubule Associated (6)

Topoisomerase (5)

SIK (5)

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NO Synthase (5)

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Glucosidase (3)

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Lipid (3)

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Antiviral (3)

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GABA Receptor (3)

Sodium Channel (3)

Tyrosinase (3)

Chloride channel (2)

NOS (2)

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BACE (2)

DYRK (2)

GTPase (2)

Transferase (2)

Integrin (2)

Adenosine Receptor (2)

IFNAR (2)

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Serine Protease (2)

Serine/threonin kinase (2)

UGT (2)

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cAMP (2)

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Beta Amyloid (2)

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ALK (2)

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Reverse Transcriptase (2)

CRISPR/Cas9 (2)

PLK (2)

Cannabinoid Receptor (2)

Anti-infection (2)

NADPH-oxidase (2)

TAM Receptor (2)

DHFR (1)

Estrogen/progestogen Receptor (1)

Arginase (1)

RAAS (1)

Tie-2 (1)

Glutathione Peroxidase (1)

ATPase (1)

Proton pump (1)

Dopamine Receptor (1)

YAP (1)

PERK (1)

OCT (1)

TRP/TRPV Channel (1)

MAO (1)

Glucocorticoid Receptor (1)

iGluR (1)

Myosin (1)

RIP kinase (1)

NMDAR (1)

MRP (1)

Pim (1)

cell cycle arrest (1)

Cysteine Protease (1)

FXR (1)

Guanylate cyclase (1)

DNA Alkylation (1)

CXCR (1)

BCRP (1)

Glutathione reductase (1)

HSP (1)

Hedgehog/Smoothened (1)

FAAH (1)

Epoxide Hydrolase (1)

Androgen Receptor (1)

OAT (1)

Histone Acetyltransferase (1)

Pyroptosis (1)

Methionine Adenosyltransferase (MAT) (1)

KLF (1)

5-HT Receptor (1)

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cholecystokinin (1)

p97 (1)

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Hydroxylase (1)

ROS Kinase (1)

PD-1/PD-L1 (1)

Kinesin (1)

S1P Receptor (1)

HER (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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