表型筛选靶点鉴定库

Target-Focused Phenotypic Screening Library

产品编号： L9500

TargetMol 表型筛选靶点鉴定库是专为表型筛选的科研工作者提供的，众所周知，表型筛选中的体外筛选，通常以细胞作为筛选工具，优点是对于靶点还不明晰，或靶点与疾病之间的关系还不明确时的药物开发，具有非常好的效果，常用于 First-in-class 药物的研发。而活性化合物的发现与靶标的鉴定两者间实现无缝对接，是学术界和产业界关注的焦点和难点。

选用靶点明确的已知活性化合物进行表型筛选，可以缩小后期靶点确认的范围，是一种较好的基于表型进行靶点鉴定的方式。该库针对表型筛选后难以确定靶点作用机制的痛点，精选了对600多个药物靶点有明确活性的 1796 个小分子组成了该化合物库。每个靶点采取2-4个结构差异较大的化合物，把表型筛选和靶点作用机制判断融为一体，是表型筛选的有力工具。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

1796种靶点明确的已知活性化合物，适合表型筛选；
覆盖600多个药物靶点，多样性好，覆盖度广，使用方便；
每个靶点对应2-4个结构差异较大的化合物，提高靶点确认的成功率；
详细的说明书，化合物结构、靶点信息、活性描述，方便科学家对结果进行分析；
NMR、HPLC/LCMS多重严苛出厂检测，保证产品结构准确，纯度高，保障实验顺利进行。

化合物库定制

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化合物库组成

Apoptosis (203)

Autophagy (195)

5-HT Receptor (65)

Antibacterial (51)

VEGFR (44)

Dopamine Receptor (41)

Adrenergic Receptor (41)

AChR (40)

DNA/RNA Synthesis (37)

Antibiotic (33)

HIV Protease (32)

Histamine Receptor (31)

PDGFR (31)

Epigenetic Reader Domain (30)

FGFR (30)

PI3K (29)

CDK (29)

PDE (28)

FLT (28)

c-Kit (28)

Src (26)

Raf (24)

EGFR (24)

P450 (24)

Histone Methyltransferase (23)

JAK (22)

HCV Protease (21)

Potassium Channel (21)

Ferroptosis (20)

Parasite (19)

Calcium Channel (19)

Bcr-Abl (19)

GluR (19)

c-Met/HGFR (18)

COX (18)

TGF-beta/Smad (18)

TRP/TRPV Channel (17)

mTOR (17)

SARS-CoV (17)

HDAC (17)

RAAS (16)

ALK (16)

Influenza Virus (16)

GPR (16)

Adenosine Receptor (15)

Proteasome (14)

p38 MAPK (14)

Dehydrogenase (14)

E1/E2/E3 Enzyme (14)

Estrogen/progestogen Receptor (13)

Mitophagy (13)

GSK-3 (13)

Topoisomerase (13)

Retinoid Receptor (13)

Carbonic Anhydrase (12)

Opioid Receptor (12)

BCL (12)

Aurora Kinase (12)

IκB/IKK (12)

c-RET (12)

Microtubule Associated (12)

DNA Alkylator/Crosslinker (11)

PPAR (11)

PARP (11)

MAO (11)

Gamma-secretase (11)

DNA Alkylation (11)

HSP (11)

GABA Receptor (11)

Sodium Channel (11)

ROR (10)

Estrogen Receptor/ERR (10)

Wnt/beta-catenin (10)

Nucleoside Antimetabolite/Analog (10)

PKC (10)

ROCK (10)

IL Receptor (10)

CXCR (10)

Chk (10)

DUB (10)

Interleukin (10)

Sirtuin (10)

Beta Amyloid (10)

MEK (10)

Monoamine Oxidase (10)

LPL Receptor (9)

NADPH (9)

Phosphatase (9)

Serine Protease (9)

Serotonin Transporter (9)

Serine/threonin kinase (9)

ERK (9)

Hedgehog/Smoothened (9)

Prostaglandin Receptor (9)

Trk receptor (9)

STAT (9)

HIF/HIF Prolyl-Hydroxylase (9)

S1P Receptor (9)

DNA-PK (8)

Antifungal (8)

Virus Protease (8)

PKA (8)

iGluR (8)

HSV (8)

Endothelin Receptor (8)

Norepinephrine (8)

CaMK (8)

Indoleamine 2,3-Dioxygenase (IDO) (8)

SGLT (8)

Akt (8)

Casein Kinase (8)

ATM/ATR (8)

Reverse Transcriptase (8)

c-Fms (8)

NF-κB (8)

PLK (8)

Cannabinoid Receptor (8)

DNA Methyltransferase (8)

S6 Kinase (8)

HER (8)

ATPase (7)

P2Y Receptor (7)

JNK (7)

Cysteine Protease (7)

Glucokinase (7)

NMDAR (7)

CCR (7)

MMP (7)

P-gp (7)

Endogenous Metabolite (7)

HIF (7)

TNF (7)

Syk (7)

Ras (7)

TAM Receptor (7)

CFTR (7)

Mdm2 (6)

Proton pump (6)

Transferase (6)

Monocarboxylate transporter (6)

Lipase (6)

HBV (6)

Tyrosine Kinases (6)

Rho (6)

Glucocorticoid Receptor (6)

BTK (6)

Mitochondrial Metabolism (6)

Smo (6)

OX Receptor (6)

TLR (6)

AMPK (6)

Sigma receptor (6)

NAMPT (5)

Caspase (5)

Drug Metabolite (5)

Reactive Oxygen Species (5)

DPP-4 (5)

FAAH (5)

MAPK (5)

LRRK2 (5)

PDK (5)

Phospholipase (5)

NOD (5)

FAK (5)

p53 (5)

PD-1/PD-L1 (5)

Kinesin (5)

Thyroid hormone receptor(THR) (4)

Reductase (4)

Histone Demethylase (4)

PERK (4)

Tie-2 (4)

CaSR (4)

Aryl Hydrocarbon Receptor (4)

IDO (4)

CSF-1R (4)

IRE1 (4)

Annexin A (4)

RIP kinase (4)

DNA gyrase (4)

PAK (4)

cAMP (4)

IGF-1R (4)

Androgen Receptor (4)

PGE Synthase (4)

Acyltransferase (4)

MNK (4)

Porcupine (4)

Ephrin Receptor (4)

Histone Acetyltransferase (4)

transporter (4)

Nrf2 (4)

PAI-1 (4)

Acetyl-CoA Carboxylase (4)

ribosome (4)

Aromatase (4)

BMI-1 (4)

HMG-CoA Reductase (4)

p97 (4)

AhR (4)

NOD-like Receptor (NLR) (4)

PKM (4)

CAT (3)

DHFR (3)

DprE1 (3)

Na+/Ca2+ Exchanger (3)

CETP (3)

Factor Xa (3)

Progesterone Receptor (3)

Melatonin Receptor (3)

GNRH Receptor (3)

MRP (3)

Pim (3)

Liver X Receptor (3)

LIM Kinase (3)

FXR (3)

P2X Receptor (3)

ROS (3)

Fatty Acid Synthase (3)

ACK (3)

DNA (3)

Telomerase (3)

ATP Citrate Lyase (3)

AChE (3)

STING (3)

Free radical scavengers (3)

RSV (3)

Neprilysin (3)

Hydroxylase (3)

Neurokinin receptor (3)

advanced glycation end products (2)

PROTACs (2)

NOS (2)

Ligands for Target Protein for PROTAC (2)

YAP (2)

LTR (2)

IFNAR (2)

Glutathione Peroxidase (2)

c-Myc (2)

Antifolate (2)

Leukotriene Receptor (2)

Myosin (2)

UGT (2)

MTH1 (2)

GRK (2)

MT Receptor (2)

Phosphorylase (2)

Antifection (2)

Monoamine Transporter (2)

PGC-1α (2)

Vasopressin Receptor (2)

Xanthine Oxidase (2)

Lipoxygenase (2)

Wee1 (2)

BCRP (2)

Beta-Secretase (2)

Survivin (2)

Antiviral (2)

GPCR19 (2)

Carboxypeptidase (2)

Kras (2)

LPA Receptor (2)

PI4K (2)

CRISPR/Cas9 (2)

Gap Junction Protein (2)

NADPH-oxidase (2)

IRAK (2)

Thrombin (2)

Protease-activated Receptor (2)

MLK (2)

NO Synthase (2)

Chloride channel (1)

BACE (1)

DYRK (1)

VDA (1)

ABC (1)

Hck (1)

IAP (1)

SIK (1)

PAFR (1)

LDL (1)

GlyT (1)

Na-K-Cl cotransporter (1)

Molecular Glues (1)

HCN Channel (1)

Neuropeptide Y Receptor (1)

Stearoyl-CoA Desaturase (SCD) (1)

PTEN (1)

Lipid (1)

Aminopeptidase (1)

ASK (1)

GluCls (1)

Pyroptosis (1)

Hippo pathway (1)

GST (1)

GPX (1)

Ligand for E3 Ligase (1)

Adenosine deaminase (1)

SGK (1)

Discoidin Domain Receptor (DDR) (1)

lysosomal autophagy (1)

ROS Kinase (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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