MAPK 抑制剂库

MAPK Inhibitor Library

产品编号： L1400

MAPK 是信号从细胞表面传导到细胞核内部的重要传递者。丝裂原活化蛋白激酶（MAPK）是一组能被不同的细胞外刺激活化的蛋白激酶，如细胞因子、神经递质、激素、细胞应激及细胞黏附等。所有的真核细胞都能表达MAPK，MAPK 通路的基本组成是一种从酵母到人类都保守的三级激酶模式，包括MAPK 激酶激酶（MKKK）、MAPK 激酶（MKK）和MAPK，这三种激酶能依次激活，MAPK 链是真核生物信号传递网络中的重要途径之一，在基因表达调控和细胞质功能活动中发挥关键作用。共同调节着细胞的生长、分化、对环境的应激适应、炎症反应等多种重要的细胞生理和病理过程。

TargetMol MAPK 抑制剂库是有500 个MAPK 信号通路相关的小分子的集合，用于研究MAPK 信号通路及相关疾病药物筛选。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

500种与MAPK信号通路相关的生物活性小分子化合物的特有集合，可用于高通量筛选和高内涵筛选；
靶点含ERK、JNK、MEK、p38、MAPK、Raf、RSK、MNK等；
通过前期临床研究和临床实验，生物活性和安全性已经得到验证；
其中一些活性化合物已得到FDA批准上市；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

p38 MAPK (110)

ERK (101)

Apoptosis (74)

Raf (73)

Autophagy (66)

MAPK (57)

Ras (53)

JNK (52)

Kras (46)

MEK (44)

NF-κB (38)

S6 Kinase (30)

CDK (26)

Akt (26)

VEGFR (17)

Src (15)

TNF (15)

Rho (14)

MNK (11)

PI3K (10)

PDGFR (10)

mTOR (10)

c-Kit (10)

GSK-3 (9)

PKA (9)

Caspase (9)

Aurora Kinase (9)

Casein Kinase (9)

Endogenous Metabolite (9)

FLT (9)

MLK (9)

BCL (8)

Ferroptosis (7)

Parasite (7)

PKC (7)

JAK (7)

Antibacterial (7)

STAT (7)

ROCK (6)

IGF-1R (6)

COX (6)

TGF-beta/Smad (6)

c-RET (6)

Bcr-Abl (5)

IL Receptor (5)

MMP (5)

EGFR (5)

ASK (5)

FGFR (5)

Antifungal (4)

TOPK (4)

PARP (4)

Reactive Oxygen Species (4)

DNA/RNA Synthesis (4)

Antiviral (4)

AMPK (4)

P450 (4)

SGK (4)

FAK (4)

Tyrosine Kinases (3)

Serine Protease (3)

BTK (3)

AChE (3)

TLR (3)

Trk receptor (3)

ALK (3)

Influenza Virus (3)

c-Fms (3)

KLF (3)

Syk (3)

Antibiotic (3)

NO Synthase (3)

PROTACs (2)

Transferase (2)

Histone Methyltransferase (2)

HCV Protease (2)

Dehydrogenase (2)

Antioxidant (2)

GTPase (2)

Mitophagy (2)

Virus Protease (2)

PPAR (2)

Pim (2)

PYK2 (2)

Calcium Channel (2)

Aryl Hydrocarbon Receptor (2)

Drug Metabolite (2)

Mitochondrial Metabolism (2)

Antifection (2)

ROS (2)

Chk (2)

ACK (2)

Epigenetic Reader Domain (2)

P-gp (2)

Nrf2 (2)

GPR (2)

PDK (2)

Potassium Channel (2)

AChR (2)

IRAK (2)

HER (2)

Apelin receptor (1)

ATPase (1)

MyD88 (1)

Estrogen/progestogen Receptor (1)

c-Met/HGFR (1)

BACE (1)

DYRK (1)

Histamine Receptor (1)

Tie-2 (1)

Glutathione Peroxidase (1)

c-Myc (1)

HBV (1)

Wnt/beta-catenin (1)

TRP/TRPV Channel (1)

Adrenergic Receptor (1)

CSF-1R (1)

iGluR (1)

Topoisomerase (1)

RIP kinase (1)

PDE (1)

LDL (1)

NMDAR (1)

Glucosidase (1)

DNA Alkylation (1)

PTEN (1)

GluR (1)

cAMP (1)

Interleukin (1)

Beta-Secretase (1)

PGE Synthase (1)

HSP (1)

Prostaglandin Receptor (1)

LRRK2 (1)

Ephrin Receptor (1)

transporter (1)

PAI-1 (1)

MELK (1)

IκB/IKK (1)

Hippo pathway (1)

Beta Amyloid (1)

GPX (1)

Aromatase (1)

5-HT Receptor (1)

Hydroxylase (1)

RXFP receptor (1)

DAPK (1)

NADPH-oxidase (1)

BMI-1 (1)

Sodium Channel (1)

Tyrosinase (1)

Protease-activated Receptor (1)

HIF/HIF Prolyl-Hydroxylase (1)

AhR (1)

p53 (1)

PD-1/PD-L1 (1)

Kinesin (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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