糖代谢化合物库

Glycometabolism Compound Library

产品编号： L2520

糖类是血清代谢物质的一种，糖代谢对机体新陈代谢有重要意义，代谢异常时可引发机体各种疾病，如糖尿病及其并发症、蚕豆病、肝病等。

此外，糖代谢异常是肿瘤代谢突出的特征之一。糖酵解是生物体内普遍存在的能量代谢过程，指在氧气不充分的条件下，葡萄糖经一系列酶促反应生成丙酮酸，进而还原成乳酸的过程，也称无氧氧化。在有氧的情况下，机体细胞主要通过氧化磷酸化途径获得能量，糖酵解受到抑制。然而在恶性肿瘤中，即使氧供应充分，糖酵解也十分活跃。肿瘤细胞有氧糖酵解能力是正常细胞的20 ～ 30倍，为肿瘤代谢提供大量能量和中间产物，此即Warburg 效应。因此，靶向糖酵解等异常环节的代谢酶是抗肿瘤治疗的重点。一些研究显示，抑制肿瘤细胞糖酵解途径能够有效抑制肿瘤细胞的增殖甚至可以起到杀伤肿瘤细胞的作用。

研究糖代谢对某些相关疾病的治疗具有重要意义，TargetMol 糖代谢化合物库提供1196 种糖代谢相关的化合物，作用靶点包含GLUTs、Hexokinase（HK）、Pyruvate Kinase（PK ）、phosphofructokinase（PFK）、IDH1/2、LDH、AMPK 等糖代谢相关靶点，是研究糖代谢紊乱疾病、癌症等的有效工具。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

1196种糖代谢相关的化合物，可用于高通量和高内涵筛选；
作用靶点包含GLUTs、Hexokinase（HK）、Pyruvate Kinase（PK）、phosphofructokinase（PFK）、IDH1/2、LDH、AMPK等糖代谢相关靶点；
详细的说明书，化合物结构、靶点信息、活性描述等；
NMR和HPLC检测技术保证产品高纯度和高质量；
所有化合物现货供应。

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化合物库组成

PI3K (168)

Apoptosis (113)

Autophagy (102)

PPAR (95)

Phosphatase (89)

GSK-3 (78)

mTOR (68)

Mitochondrial Metabolism (51)

AMPK (51)

Carbonic Anhydrase (43)

HIF/HIF Prolyl-Hydroxylase (41)

p53 (37)

HIF (35)

CDK (33)

IGF-1R (33)

Akt (33)

DNA-PK (29)

Glucokinase (28)

Dehydrogenase (27)

DPP-4 (24)

S6 Kinase (23)

PDK (19)

Proteasome (17)

Ferroptosis (17)

Reductase (17)

SGLT (17)

ATM/ATR (17)

Glucocorticoid Receptor (16)

Src (15)

COX (14)

Mdm2 (13)

Parasite (13)

Glucosidase (12)

Antibacterial (12)

transporter (12)

NAMPT (11)

Isocitrate Dehydrogenase (IDH) (11)

Antibiotic (11)

VEGFR (10)

Potassium Channel (10)

Calcium Channel (9)

PKC (9)

Reactive Oxygen Species (9)

SGK (9)

NADPH (8)

FLT (8)

PKM (8)

Mitophagy (7)

PKA (7)

Wnt/beta-catenin (7)

PDE (7)

Chk (7)

Aurora Kinase (7)

PI4K (7)

P450 (7)

ROCK (6)

Casein Kinase (6)

Endogenous Metabolite (6)

ATPase (5)

HIV Protease (5)

Antifungal (5)

Bcr-Abl (5)

DNA/RNA Synthesis (5)

NF-κB (5)

FGFR (5)

Microtubule Associated (5)

FAK (5)

PERK (4)

TRP/TRPV Channel (4)

SIK (4)

ROS (4)

PDGFR (4)

EGFR (4)

ALK (4)

Influenza Virus (4)

IκB/IKK (4)

NADPH-oxidase (4)

c-Met/HGFR (3)

Antioxidant (3)

DYRK (3)

Virus Protease (3)

ERK (3)

Adrenergic Receptor (3)

E1/E2/E3 Enzyme (3)

Hexokinase (3)

HSV (3)

IL Receptor (3)

MMP (3)

Androgen Receptor (3)

Interleukin (3)

MAPK (3)

Prostaglandin Receptor (3)

STAT (3)

HDAC (3)

Syk (3)

Sodium Channel (3)

Tyrosinase (3)

Chloride channel (2)

Transferase (2)

Histone Methyltransferase (2)

ADC Cytotoxin (2)

p38 MAPK (2)

Estrogen/progestogen Receptor (2)

IFNAR (2)

JNK (2)

Tyrosine Kinases (2)

Serine Protease (2)

Aryl Hydrocarbon Receptor (2)

Gamma-secretase (2)

Raf (2)

Phosphorylase (2)

DNA Alkylation (2)

PGC-1α (2)

Epigenetic Reader Domain (2)

TGF-beta/Smad (2)

OXPHOS (2)

HSP (2)

Trk receptor (2)

Sirtuin (2)

Nrf2 (2)

MELK (2)

Beta Amyloid (2)

c-Fms (2)

GPR (2)

Hydroxylase (2)

PLK (2)

c-RET (2)

MEK (2)

Cannabinoid Receptor (2)

DNA Methyltransferase (2)

Proton pump (1)

NOS (1)

Monocarboxylate transporter (1)

Dopamine Receptor (1)

YAP (1)

DNA Alkylator/Crosslinker (1)

Adenosine Receptor (1)

BACE (1)

Histone Demethylase (1)

RAAS (1)

Tie-2 (1)

GTPase (1)

Progesterone Receptor (1)

ABC (1)

HBV (1)

PARP (1)

Pim (1)

Rho (1)

Serine/threonin kinase (1)

Cysteine Protease (1)

Leukotriene Receptor (1)

PYK2 (1)

Caspase (1)

Glutaminase (1)

MAO (1)

CSF-1R (1)

Immunology/Inflammation related (1)

iGluR (1)

Myosin (1)

FLAP (1)

Drug Metabolite (1)

Guanylate cyclase (1)

BCL (1)

Fatty Acid Synthase (1)

PAK (1)

JAK (1)

PTEN (1)

Epoxide Hydrolase (1)

cAMP (1)

GluR (1)

Lipoxygenase (1)

CaMK (1)

DUB (1)

ATP Citrate Lyase (1)

Lipid (1)

Beta-Secretase (1)

AChE (1)

Acyltransferase (1)

P-gp (1)

STING (1)

LRRK2 (1)

Free radical scavengers (1)

AIM2 (1)

CPT (1)

Reverse Transcriptase (1)

Ligand for E3 Ligase (1)

Phospholipase (1)

GABA Receptor (1)

TNF (1)

AChR (1)

DAPK (1)

Anti-infection (1)

c-Kit (1)

cholecystokinin (1)

Thrombin (1)

AhR (1)

NOD-like Receptor (NLR) (1)

CFTR (1)

MLK (1)

S1P Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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