血管生成库 | TargetMol

Angiogenesis related Compound Library

产品编号： L4800

血管生成是正常生长和发育过程以及伤口愈合和肉芽组织形成过程中的基本事件，然而异常的血管生成将导致各种疾病，例如肿瘤、糖尿病、免疫病、先兆子痫、肢体缺血等。因此，血管生成已成为治疗这些疾病的药物靶点。例如，血管生成与癌症发生密切相关，肿瘤通过分泌各种生长因子（例如VEGF）和蛋白质诱导毛细血管生成进入肿瘤，为癌细胞提供氧气和其他必需的营养物质，并及时运走代谢废物，血管生成也是肿瘤扩散或转移所必需的。因此血管生成抑制剂用于治疗癌症。此外，诱导血管生成，建立新的侧支循环是治疗缺血性心脑血管疾病（冠心病、脑卒中等）的极佳治疗方式。有效新生血管靶分子的筛选为相关疾病研究带来了广阔前景。

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陶术生物化合物库目录(2.8MB)

库化合物信息

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产品描述

2300个高潜力的抑制或促进血管生成的小分子集合，可用于药物靶点开发、血管生成机理研究的高通量筛选，高内涵筛选；
包含了目前研究较多潜力的血管生成通路以及S1P、VEGFR、PDGF等相关靶点的热门产品；
包含了Sunitinib Malate、Lenalidomide、sorafenib、Erlotinib等研究成熟的上市药物，以及Vatalanib、Orantinib、2-Methoxyestradiol（Panzem）、Celecoxib等临床药物；
是研究血管生成机理以及药物靶向研究的有效工具；
产品经过临床验证和临床实验，具有生物安全保障和一定的生物活性；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR和HPLC检测技术保证产品高纯度和高质量；
所有化合物现货供应。

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化合物库组成

5-HT Receptor (338)

Apoptosis (190)

EGFR (183)

Autophagy (182)

PI3K (166)

VEGFR (156)

JAK (102)

FLT (101)

Src (98)

mTOR (97)

PDGFR (91)

Dopamine Receptor (89)

COX (84)

FGFR (80)

GSK-3 (79)

Bcr-Abl (69)

c-Kit (67)

ALK (63)

Akt (62)

BTK (59)

p38 MAPK (56)

CDK (54)

Adrenergic Receptor (52)

TGF-beta/Smad (50)

HER (50)

AMPK (47)

TNF (46)

Tyrosine Kinases (42)

HIF/HIF Prolyl-Hydroxylase (42)

Histamine Receptor (41)

DNA-PK (38)

CXCR (37)

HIF (36)

FAK (32)

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S6 Kinase (29)

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化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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