抗癌临床化合物库

Anti-Cancer Clinical Compound Library

产品编号： L2120

尽管在过去的几十年中癌症的研究和治疗取得了巨大的成功，但癌症仍然是人类面临的巨大挑战，给患者身心健康带来巨大的痛苦。癌细胞具有许多显著不同的生物学特征，表现出无限的增殖潜能，维持自身生长信号的持续稳定，逃避应激信号(例如治疗药物)诱导的细胞凋亡，刺激血管生长，为肿瘤提供营养，同时逃避免疫系统防御和诱导局部慢性炎症，发挥其侵袭和转移能力，表现出异常的代谢活动，并通过突变和表观遗传机制显著改变全基因组的稳定性。

抗癌活性的药物是临床研究的热点之一，根据文献报道和有关公开资料，我们收集了2545 个具有抗癌活性或潜在抗癌活性的处于临床试验阶段的化合物，组成抗癌临床化合物库，可用于癌症相关研究及高通量高内涵筛选。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

2545个具有抗癌活性小分子的独特集合，可用于高通量高内涵筛选；
生物活性已经临床前实验证实，所有化合物均已进入临床实验阶段的抗癌化合物；
包括肺癌、乳腺癌、白血病、淋巴瘤等15种癌症，是癌症相关研究的有效筛选工具；
作用靶点涉及PI3K,HDAC, mTOR, CDK, JAK 等癌症相关靶点；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Apoptosis (295)

Autophagy (285)

5-HT Receptor (147)

Adrenergic Receptor (110)

Dopamine Receptor (86)

DNA/RNA Synthesis (80)

Histamine Receptor (76)

VEGFR (76)

COX (73)

EGFR (63)

Sodium Channel (62)

Antibacterial (60)

Calcium Channel (59)

PI3K (58)

Antibiotic (56)

FLT (55)

CDK (52)

Potassium Channel (51)

PDGFR (50)

c-Kit (46)

P450 (45)

Glucocorticoid Receptor (44)

JAK (44)

FGFR (44)

c-Met/HGFR (38)

mTOR (37)

HDAC (36)

Src (35)

HIV Protease (34)

PPAR (34)

Parasite (33)

Prostaglandin Receptor (32)

Topoisomerase (31)

AChR (31)

Dehydrogenase (28)

Tyrosine Kinases (28)

Bcr-Abl (28)

GABA Receptor (28)

Nucleoside Antimetabolite/Analog (27)

GPR (27)

Microtubule Associated (27)

Raf (26)

Ferroptosis (25)

Antifungal (25)

Reactive Oxygen Species (24)

Androgen Receptor (23)

SARS-CoV (23)

Estrogen/progestogen Receptor (22)

Adenosine Receptor (22)

Estrogen Receptor/ERR (22)

PARP (22)

Aurora Kinase (22)

HER (22)

BTK (20)

Epigenetic Reader Domain (20)

Akt (20)

NF-κB (20)

MEK (20)

Mitophagy (19)

p38 MAPK (18)

PDE (18)

Opioid Receptor (18)

Norepinephrine (18)

Endogenous Metabolite (18)

Serotonin Transporter (17)

iGluR (17)

HSP (17)

Trk receptor (17)

ALK (17)

c-RET (17)

ADC Cytotoxin (16)

RAAS (16)

P-gp (16)

DNA Alkylator/Crosslinker (15)

Endothelin Receptor (15)

ATPase (14)

Phosphatase (14)

GSK-3 (14)

HBV (14)

TRP/TRPV Channel (14)

ERK (14)

CXCR (14)

SGLT (14)

c-Fms (14)

TAM Receptor (14)

Proton pump (13)

DNA-PK (13)

Guanylate cyclase (13)

HSV (13)

Chk (13)

Influenza Virus (13)

Proteasome (12)

HCV Protease (12)

E1/E2/E3 Enzyme (12)

NMDAR (12)

ROS (12)

Retinoid Receptor (12)

Histone Methyltransferase (11)

LPL Receptor (11)

Progesterone Receptor (11)

Virus Protease (11)

PKC (11)

DNA Alkylation (11)

Reverse Transcriptase (11)

HIF/HIF Prolyl-Hydroxylase (11)

CFTR (11)

S1P Receptor (11)

Carbonic Anhydrase (10)

GNRH Receptor (10)

Antifolate (10)

Gamma-secretase (10)

STAT (10)

AMPK (10)

TNF (10)

FAK (10)

P2Y Receptor (9)

Caspase (9)

CSF-1R (9)

Hedgehog/Smoothened (9)

IL Receptor (9)

Vasopressin Receptor (9)

Interleukin (9)

HIF (9)

Syk (9)

S6 Kinase (9)

DHFR (8)

JNK (8)

ROCK (8)

P2X Receptor (8)

IGF-1R (8)

Indoleamine 2,3-Dioxygenase (IDO) (8)

ATM/ATR (8)

Kras (8)

Cannabinoid Receptor (8)

ROS Kinase (8)

p53 (8)

Kinesin (8)

Mdm2 (7)

Transferase (7)

PKA (7)

Wnt/beta-catenin (7)

Mitochondrial Metabolism (7)

Antifection (7)

Smo (7)

BCL (7)

OX Receptor (7)

GluR (7)

DNA (7)

TGF-beta/Smad (7)

TLR (7)

PLK (7)

Neurokinin receptor (7)

Sigma receptor (7)

Integrin (6)

Pim (6)

MAO (6)

IAP (6)

RIP kinase (6)

Drug Metabolite (6)

Glucagon Receptor (6)

Isocitrate Dehydrogenase (IDH) (6)

MMP (6)

Casein Kinase (6)

Beta Amyloid (6)

Ligand for E3 Ligase (6)

Phospholipase (6)

DNA Methyltransferase (6)

IRAK (6)

HMG-CoA Reductase (6)

Monoamine Oxidase (6)

Histone Demethylase (5)

Tie-2 (5)

MRP (5)

Serine Protease (5)

Leukotriene Receptor (5)

DPP-4 (5)

CCR (5)

Bradykinin Receptor (5)

Ephrin Receptor (5)

Nrf2 (5)

GHSR (5)

Hydroxylase (5)

Thrombin (5)

Antioxidant (4)

IFNAR (4)

CaSR (4)

IDO (4)

Molecular Glues (4)

Fatty Acid Synthase (4)

PAK (4)

KSP (4)

Lipoxygenase (4)

Wee1 (4)

PGE Synthase (4)

STING (4)

Sirtuin (4)

CRFR (4)

Aromatase (4)

CGRP Receptor (4)

cholecystokinin (4)

NO Synthase (4)

Chloride channel (3)

PROTACs (3)

CRM1 (3)

YAP (3)

NADPH (3)

Glutathione Peroxidase (3)

Melatonin Receptor (3)

Rho (3)

Serine/threonin kinase (3)

NAMPT (3)

Annexin A (3)

Na-K-Cl cotransporter (3)

Monoamine Transporter (3)

Neuropeptide Y Receptor (3)

Somatostatin (3)

Xanthine Oxidase (3)

CaMK (3)

DUB (3)

PSMA (3)

AChE (3)

OAT (3)

Antiviral (3)

Free radical scavengers (3)

RSV (3)

IκB/IKK (3)

ribosome (3)

Melanocortin Receptor (3)

Adenosine deaminase (3)

Ras (3)

Protease-activated Receptor (3)

AhR (3)

PD-1/PD-L1 (3)

NOS (2)

ROR (2)

NEDD8 (2)

Ligands for Target Protein for PROTAC (2)

LTR (2)

Reductase (2)

PERK (2)

VDA (2)

ABC (2)

Cysteine Protease (2)

Liver X Receptor (2)

FXR (2)

PYK2 (2)

IRE1 (2)

MT Receptor (2)

HCN Channel (2)

Telomerase (2)

BCRP (2)

Beta-Secretase (2)

MAPK (2)

Porcupine (2)

GPCR19 (2)

CD73 (2)

transporter (2)

Drug-Linker Conjugates for ADC (2)

GST (2)

LPA Receptor (2)

Oxytocin Receptor (2)

Gap Junction Protein (2)

Discoidin Domain Receptor (DDR) (2)

p97 (2)

NOD-like Receptor (NLR) (2)

MLK (2)

advanced glycation end products (1)

CAT (1)

NPC1L1 (1)

Monocarboxylate transporter (1)

MALT (1)

DYRK (1)

RAR/RXR (1)

TOPK (1)

GTPase (1)

Factor Xa (1)

c-Myc (1)

Galectin (1)

Kisspeptin (1)

N-Acetylglucosaminyltransferase (1)

Hck (1)

Glucokinase (1)

Stemness kinase (1)

Glutaminase (1)

Aryl Hydrocarbon Receptor (1)

Myosin (1)

Motilin Receptor (1)

PAFR (1)

MTH1 (1)

LDL (1)

GRK (1)

DNA gyrase (1)

GlyT (1)

Hexokinase (1)

Anion Exchanger (1)

PROTAC Linker (1)

Thioredoxin (1)

ACK (1)

ATP Citrate Lyase (1)

Acyltransferase (1)

Survivin (1)

MNK (1)

Aminopeptidase (1)

Decarboxylase (1)

ASK (1)

PAI-1 (1)

Pyroptosis (1)

MELK (1)

Methionine Adenosyltransferase (MAT) (1)

Neprilysin (1)

Hippo pathway (1)

PI4K (1)

KLF (1)

PDK (1)

Aquaporin (1)

SGK (1)

Complement System (1)

NADPH-oxidase (1)

BMI-1 (1)

NOD (1)

Imidazoline Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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