PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T18097	m-PEG-NH2 (MW 1000)	m-PEG-NH2 (MW 1000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17683	Boc-NH-PEG8-CH2CH2COOH	Boc-NH-PEG8-CH2CH2COOH 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T18656	S-acetyl-PEG2-Boc	S-acetyl-PEG2-Boc (S-Acetyl-PEG2-T-Butyl Ester) 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T18014	HO-PEG24-OH	HO-PEG24-OH 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T17483	Azido-PEG11-azide	Azido-PEG11-azide 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T18035	Hydroxy-PEG12-Boc	Hydroxy-PEG12-Boc (Hydroxy-PEG12-T-Butyl Ester) 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T17663	Boc-NH-PEG10-NHS ester	Boc-NH-PEG10-NHS ester （t-Boc-N-amido-PEG10-NHS ester）是一种属于 PEG 类的 PROTAC linker，可用于合成 PROTAC 分子。
T38453	Bromo-PEG7-azide	Bromo-PEG7-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

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PROTAC Linker