PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T17786	DBCO-PEG2-amine	DBCO-PEG2-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14627	Bis-PEG1-NHS ester	Bis-PEG1-NHS ester is a non-cleavable 1-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.
T15122	Diethyl 7-bromoheptylphosphonate	Diethyl 7-bromoheptylphosphonate is an alkyl chain-based PROTAC linker, commonly employed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T15909	m-PEG6-Br	m-PEG6-Br is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18085	m-PEG-azide (MW 5000)	m-PEG-azide (MW 5000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15540	Hydroxy-PEG9-Boc	Hydroxy-PEG9-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18265	Mal-PEG-mal (MW 5000)	Mal-PEG-mal (MW 5000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14608	Biotin-PEG6-Mal	Biotin-PEG6-Mal is a biotinylated PROTAC linker derived from a polyethylene glycol (PEG) scaffold. It serves as an essential component for the synthesis of PROTACs, which are targeted protein degraders[1].
T18187	m-PEG3-Sulfone-PEG3-Boc	m-PEG3-Sulfone-PEG3-Boc is a polyethylene glycol (PEG)-derived proteolysis-targeting chimera (PROTAC) linker employed for the synthesis of PROTACs[1].
T17765	DBCO-NHCO-PEG2-CH2COOH	DBCO-NHCO-PEG2-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18095	m-PEG-mal (MW 30000)	m-PEG-mal (MW 30000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17488	Azido-PEG15-t-butyl ester	Azido-PEG15-t-butyl ester is a polyethylene glycol (PEG) derived linker, specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T18254	Mal-NH-PEG12-CH2CH2COOPFP ester	Mal-NH-PEG12-CH2CH2COOPFP ester is a polyethylene glycol (PEG) based linker molecule, designed specifically for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T14887	Cbz-NH-PEG2-C2-acid	Cbz-NH-PEG2-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14653	Bis-propargyl-PEG1	Bis-propargyl-PEG1 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18705	SPDMB	SPDMB is a glutathione-cleavable ADC linker used for antibody-drug conjugates (ADCs).
T14437	Azido-PEG4-4-nitrophenyl carbonate	Azido-PEG4-4-nitrophenyl carbonate, a PEG-derived PROTAC linker, enables the synthesis of PROTACs[1].
T18706	SPDMV-sulfo	SPDMV-sulfo, a glutathione-cleavable ADC linker, facilitates the release of drugs from antibody-drug conjugates (ADCs).
T17584	Biotin-PEG4-Dde-TAMRA-PEG3-Azide	Biotin-PEG4-Dde-TAMRA-PEG3-Azide is a seven-unit polyethylene glycol (PEG) linker that is cleavable and employed in the synthetic production of antibody-drug conjugates (ADCs)[1].
T18564	Propargyl-O-C1-amido-PEG4-C2-NHS ester	Propargyl-O-C1-amido-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

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PROTAC Linker