PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T17994	H2N-PEG8-Hydrazide	H2N-PEG8-Hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14111	Acid-PEG6-C2-Boc	Acid-PEG6-C2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15886	m-PEG4-Tos	m-PEG4-Tos, a PEG-based PROTAC linker derived from silybin ethers, finds application in the synthesis of Silymarin[1].
T18833	Thiol-PEG-CH2COOH (MW 3400)	Thiol-PEG-CH2COOH (MW 3400) is a Polyethylene Glycol (PEG) derivative employed as a PROTAC linker for PROTAC synthesis[1].
T14101	Acid-PEG3-C2-Boc	Acid-PEG3-C2-Boc is a compound used as a linker in the synthesis of PROTACs to facilitate the degradation of EGFR and the inhibition of mTOR[1][2]. It is classified as a PEG- and alkyl/ether-based PROTAC linker.
T18272	Mal-PEG12-Boc	Mal-PEG12-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18211	m-PEG6-Hydrazide	m-PEG6-Hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16256	N3-PEG3-C2-PFP ester	N3-PEG3-C2-PFP ester is a 3-unit polyethylene glycol (PEG) linker devoid of cleavable bonds. It is commonly employed in the synthesis of antibody-drug conjugates (ADCs).
T14832	BS2G Crosslinker disodium	BS2G Crosslinker (disodium) is a non-cleavable linker employed for synthesizing antibody-drug conjugates (ADCs)[1].
T17382	Ald-Ph-amido-PEG2	Ald-Ph-amido-PEG2 is a noncleavable ADC linker for antibody-drug conjugates (ADCs)[1].
T17468	Azide-PEG3-L-alanine-Fmoc	Azide-PEG3-L-alanine-Fmoc is a polyethylene glycol (PEG)-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].
T15152	DNP-PEG4-acid	DNP-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15316	Fmoc-NH-PEG3-CH2CH2COOH	Fmoc-NH-PEG3-CH2CH2COOH is a cleavable ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T18185	m-PEG3-Sulfone-PEG3-acid	m-PEG3-Sulfone-PEG3-acid is a polyethylene glycol (PEG)-based protein degradation utilizing targeted chimera (PROTAC) linker [1].
T14447	Azido-PEG4-(CH2)3OH	Azido-PEG4-(CH2)3OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16301	NH-bis-PEG2	NH-bis-PEG2 is a non-cleavable 2-unit PEG ADC linker used in synthesizing antibody-drug conjugates (ADCs).
T17487	Azido-PEG15-azide	Azido-PEG15-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17784	DBCO-PEG13-DBCO	DBCO-PEG13-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17530	BCN-PEG3-oxyamine	BCN-PEG3-oxyamine is a non-cleavable three-unit polyethylene glycol linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T17581	Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne	Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne functions as a PEG-based linker for PROTAC synthesis[1].

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PROTAC Linker