PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T16623	Propargyl-PEG4-CH2-methyl ester	Propargyl-PEG4-CH2-methyl ester is a PEGylated linker compound utilized for the synthesis of PROTACs.
T17490	Azido-PEG16-Boc	Azido-PEG16-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16049	Methylamino-PEG2-acid	Methylamino-PEG2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15494	HO-PEG8-CH2CH2COOH	Hydroxy-PEG8-acid (HO-PEG8-CH2CH2COOH) is a PEG-based PROTAC linker employed for PROTAC synthesis[1].
T17424	Amino-PEG25-acid	Amino-PEG25-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14234	Amino-PEG3-C2-Azido	Amino-PEG3-C2-Azido is a polyethylene glycol (PEG)-based linker used in the synthesis of iRucaparib-TP3, a PARP1 degrader [1].
T16650	Propargyl-PEG8-bromide	Propargyl-PEG8-bromide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T18311	Mc-MMAD	Mc-MMAD, a drug-linker conjugate for antibody-drug conjugates (ADCs), incorporates the protective group maleimidocaproyl (Mc) conjugated to monomethyl auristatin D (MMAD), a potent inhibitor of tubulin.
T18342	Methyltetrazine-PEG13-NHS ester	Methyltetrazine-PEG13-NHS ester is a polyethylene glycol (PEG)-derived linker, designed specifically for use in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T15832	m-PEG-OH (MW 2000)	m-PEG-OH (MW 2000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14599	Biotin-PEG4-amine	Biotin-PEG4-amine is a biotinylated, PEGylated amine linker utilized in PROTAC synthesis[1].
T17900	cIAP1 Ligand-Linker Conjugates 8	cIAP1 Ligand-Linker Conjugates 8 comprises an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is specifically utilized for the purpose of SNIPER design[1].
T16242	N-(PEG1-OH)-N-Boc-PEG2-propargyl	N-(PEG1-OH)-N-Boc-PEG2-propargyl is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T15898	m-PEG5-phosphonic acid ethyl ester	m-PEG5-phosphonic acid ethyl ester is a polyethylene glycol (PEG)-derived linker commonly employed in the construction of proteolysis targeting chimeras (PROTACs)[1].
T17429	Amino-PEG36-acid	Amino-PEG36-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18173	m-PEG25-acid	m-PEG25-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16643	Propargyl-PEG6-NH2	Propargyl-PEG6-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14018	(2-Pyridyldithio)-PEG2-Boc	(2-Pyridyldithio)-PEG2-Boc is a polyethylene glycol-based PROTAC linker utilized for the synthesis of PROTACs[1].
T16604	Propargyl-PEG2-Tos	Propargyl-PEG2-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T16375	Octaethylene glycol	Octaethylene glycol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

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PROTAC Linker