PROTAC Linker

The length and composition of the linker play critical roles in the physicochemical properties and bioactivity of PROTACs. While linker design has historically received limited attention, the PROTAC field is evolving rapidly and undergoing an important shift from synthetically tractable alkyl and polyethylene glycol to more sophisticated functional linkers. Equally important, linker-mediated binding cooperativity also represents a potential source of affinity for the POI for PROTACs based on weak affinity warheads. However, the current consensus is that the linker composition, and particularly its length and attachment point to the anchor/warhead, must be optimized for each ligand pair.

产品编号	产品名称
T18767	TCO-PEG3-maleimide	TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
T17647	Boc-C1-PEG3-C4-OH	Boc-C1-PEG3-C4-OH is an Alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs, which are characterized by their structure comprising two distinct ligands tethered by a linker. One ligand of PROTACs binds to an E3 ubiquitin ligase, while the other binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs facilitate the targeted degradation of specific proteins[1].
T17339	(5,6)TAMRA-PEG3-Azide-PEG3-Desthiobiotin	(5,6)TAMRA-PEG3-Azide-PEG3-Desthiobiotin is a polyethylene glycol (PEG)-based PROTAC linker utilized for the synthesis of PROTACs.
T17986	Gly-Gly-Gly-PEG3-TCO	Gly-Gly-Gly-PEG3-TCO is a cleavable three-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T16222	N-Bromoacetyl-β-alanine	N-Bromoacetyl-β-alanine is an alkyl chain-derived PROTAC linker utilized for synthesizing PROTACs[1]. Moreover, it serves as a cleavable ADC linker in the production of antibody-drug conjugates (ADCs)[2].
T14789	Bromo-PEG2-C2-acid	Bromo-PEG2-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17124	Tos-PEG2-CH2COOH	Tos-PEG2-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17966	Fmoc-NH-PEG11-CH2COOH	Fmoc-NH-PEG11-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T14624	Bis-Mal-Lysine-PEG4-TFP ester	Bis-Mal-Lysine-PEG4-TFP ester, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].
T18273	Mal-PEG12-DSPE	Mal-PEG12-DSPE is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18626	Dox-Ph-PEG1-Cl	Dox-Ph-PEG1-Cl, also referred to as PROTAC Linker 34, is a PEG-based compound employed for the synthesis of PROTACs[1].
T14713	Boc-Aminooxy-PEG3-azide	Boc-Aminooxy-PEG3-azide is a polyethylene glycol (PEG) derived PROTAC linker, specifically designed for the synthesis of PROTACs[1].
T14277	Aminooxy-PEG7-methane	Aminooxy-PEG7-methane is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17709	Carboxymethyl-PEG-Carboxymethyl (MW 5000)	Carboxymethyl-PEG-Carboxymethyl (MW 5000) is a polyethylene glycol (PEG)-based linker, specifically designed for the synthesis of PROTACs [1].
T15222	endo-BCN-PEG2-alcohol	endo-BCN-PEG2-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15315	Fmoc-NH-PEG2-CH2CH2COOH	Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].
T18247	Mal-C2-Gly3-EDA	Mal-C2-Gly3-EDA is a cleavable antibody-drug conjugate (ADC) linker equipped with a Maleimide moiety. It serves the purpose of facilitating the synthesis of ADCs.
T17502	Azido-PEG3-S-PEG3-azide	Azido-PEG3-S-PEG3-azide is a polyethylene glycol (PEG)-derived linker specifically designed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T17951	Fmoc-Gly-Gly-D-Phe-OtBu	Fmoc-Gly-Gly-D-Phe-OtBu, an ADC cleavable linker, is utilized in the synthesis of antibody-drug conjugates. It is the R-isomer of Fmoc-Gly-Gly-Phe-OtBu [1].
T18458	N,N'-DME-N,N'-Bis-PEG2-acid	N,N'-DME-N,N'-Bis-PEG2-acid is a polyethylene glycol (PEG)-derived linker used for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

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PROTAC Linker