Wnt/Hedgehog/Notch 通路化合物库

Wnt/Hedgehog/Notch Compound Library

产品编号： L4300

Wnt 信号通路在动物中高度保守，在动物胚胎发育中发挥重要作用，其异常表达或激活能引起肿瘤。Hedgehog（Hh）信号通路在多种生理过程中起着关键作用，如胚胎发育及维持成人机体内环境稳定等。近年来多项研究表明在皮肤基底细胞癌、髓母细胞瘤、肺癌、消化道肿瘤、乳腺癌等多种肿瘤组织中都存在Hh 信号通路的异常激活，并与肿瘤的增殖分化、细胞凋亡、血管新生、侵袭转移等密切相关，提示异常激活的Hh 信号通路在肿瘤发生、发展过程中其重要作用，阻断肿瘤中Hh 信号通路将为人类肿瘤的治疗提供一个新的有效途径。Notch 信号通路广泛存在于脊椎和无脊椎动物，在进化上高度保守，通过相邻细胞之间的相互作用调节细胞、组织、器官的分化和发育。目前Notch 信号异常已经与多种疾病联系起来，包括肿瘤、CADASIL 综合征、Alagille 综合征、脊椎肋骨发育不全等。

TargetMol 可以为您提供多个Wnt & Hedgehog & Notch 信号通路研究相关的优质产品，为您的相关信号通路研究及相关药物筛选提供有效工具。

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产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

398个Wnt & Hedgehog & Notch靶点相关的生物活性小分子化合物的特有集合，用于相关通路的研究及药物的筛选，可用于高通量、高内涵筛选。
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

化合物库定制

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化合物库组成

Wnt/beta-catenin (119)

PKC (97)

GSK-3 (82)

Apoptosis (54)

Hedgehog/Smoothened (38)

Autophagy (32)

CDK (30)

ROCK (28)

Smo (24)

PKA (21)

Gamma-secretase (19)

c-Myc (17)

Antibacterial (13)

Endogenous Metabolite (13)

PARP (12)

Akt (12)

ERK (8)

Porcupine (8)

Antibiotic (7)

Src (6)

Antifungal (6)

NF-κB (6)

Serine/threonin kinase (5)

Calcium Channel (5)

BCL (5)

Reactive Oxygen Species (5)

Casein Kinase (5)

S6 Kinase (5)

HIV Protease (4)

VEGFR (4)

Epigenetic Reader Domain (4)

CaMK (4)

COX (4)

MAPK (4)

Beta Amyloid (4)

PI3K (3)

Estrogen Receptor/ERR (3)

Tyrosine Kinases (3)

Parasite (3)

Topoisomerase (3)

PDGFR (3)

Lipoxygenase (3)

Influenza Virus (3)

Syk (3)

FLT (3)

Carbonic Anhydrase (2)

Estrogen/progestogen Receptor (2)

Ferroptosis (2)

DYRK (2)

JNK (2)

gp120/CD4 (2)

Phosphatase (2)

Mitophagy (2)

Virus Protease (2)

PPAR (2)

Caspase (2)

Myosin (2)

LDL (2)

Drug Metabolite (2)

JAK (2)

Chk (2)

Aurora Kinase (2)

EGFR (2)

Lipid (2)

Antiviral (2)

STAT (2)

AMPK (2)

MEK (2)

FGFR (2)

Potassium Channel (2)

Microtubule Associated (2)

ATPase (1)

Adenylyl cyclase (1)

DHFR (1)

Dopamine Receptor (1)

HCV Protease (1)

p38 MAPK (1)

Arginase (1)

Dehydrogenase (1)

YAP (1)

Antioxidant (1)

RAAS (1)

GTPase (1)

ABC (1)

Pim (1)

Serine Protease (1)

Nucleoside Antimetabolite/Analog (1)

TRP/TRPV Channel (1)

Aryl Hydrocarbon Receptor (1)

Immunology/Inflammation related (1)

Glucocorticoid Receptor (1)

Bcr-Abl (1)

PDE (1)

GRK (1)

Glucosidase (1)

BTK (1)

Antifection (1)

HSV (1)

IL Receptor (1)

CXCR (1)

GluR (1)

IGF-1R (1)

mTOR (1)

Acyltransferase (1)

Prostaglandin Receptor (1)

Nrf2 (1)

Methionine Adenosyltransferase (MAT) (1)

GST (1)

HDAC (1)

KLF (1)

GABA Receptor (1)

5-HT Receptor (1)

P450 (1)

SGK (1)

TNF (1)

Sodium Channel (1)

cholecystokinin (1)

HIF/HIF Prolyl-Hydroxylase (1)

p53 (1)

NO Synthase (1)

S1P Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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