干细胞分化化合物库

Stem Cell Differentiation Compound Library

产品编号： L8000

干细胞具有分化成特定细胞亚型的能力，例如，胚胎干细胞可以产生所有三个胚层的细胞：外胚层、中胚层和内胚层。通常认为成体干细胞效力有限，只能分化成某些细胞类型。为了产生用于再生医学、药物筛选、疾病或发育模型相关的特化细胞类型，研究人员必须控制和指导干细胞的分化。细胞的分化方向可以通过天然或化学合成的小分子来诱导。例如，糖原合成酶激酶-3β的特异性抑制剂可以诱导多能干细胞中的神经元分化，特定细胞因子和组蛋白去乙酰化酶抑制剂丁酸钠的组合诱导干细胞分化成肝细胞等。

TargetMol 干细胞分化化合物库是1593 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合，为干细胞相关研究提供有效工具。

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产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

1593种干细胞分化信号通路相关的生物活性小分子化合物的特有集合，可用于高通量、高内涵筛选；
研究干细胞再生机理、再生疗法；?用于干细胞分化信号通路的研究以及基于干细胞的新药物筛选的有效工具；
靶点含Wnt、 GSK-3、Hedgehog、JAK、ROCK、γ-secretase等；
结构多样，药效显著，可渗透细胞；
详细的说明书、化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Apoptosis (190)

EGFR (164)

Autophagy (157)

PI3K (113)

Wnt/beta-catenin (91)

JAK (88)

GSK-3 (76)

mTOR (59)

STAT (53)

Histone Methyltransferase (52)

TGF-beta/Smad (52)

CDK (50)

Kras (50)

ROCK (45)

Ras (45)

HER (44)

Akt (42)

Casein Kinase (40)

Gamma-secretase (38)

PPAR (35)

ALK (34)

Hedgehog/Smoothened (33)

Src (32)

p38 MAPK (31)

VEGFR (29)

Tyrosine Kinases (28)

FLT (27)

S6 Kinase (25)

ERK (24)

DNA-PK (23)

PKA (21)

Pim (21)

Raf (21)

Smo (21)

IGF-1R (21)

AMPK (21)

PKC (20)

Histone Demethylase (19)

PDGFR (19)

Aurora Kinase (18)

ATM/ATR (18)

Potassium Channel (18)

YAP (17)

FGFR (17)

Bcr-Abl (16)

Epigenetic Reader Domain (16)

p53 (15)

Rho (13)

MAPK (13)

Beta Amyloid (13)

MEK (13)

Ferroptosis (12)

PARP (12)

c-Kit (12)

Antibiotic (12)

COX (11)

Antibacterial (11)

BTK (10)

CXCR (10)

Histone Acetyltransferase (10)

5-HT Receptor (10)

DNA Methyltransferase (10)

Mdm2 (9)

Mitophagy (9)

Calcium Channel (9)

Sirtuin (9)

P450 (9)

c-Met/HGFR (8)

JNK (8)

Adrenergic Receptor (8)

E1/E2/E3 Enzyme (8)

PDE (8)

c-RET (8)

Dehydrogenase (7)

Serine/threonin kinase (7)

Chk (7)

DNA/RNA Synthesis (7)

Beta-Secretase (7)

Porcupine (7)

HDAC (7)

PI4K (7)

PDK (7)

NF-κB (7)

BACE (6)

DYRK (6)

Histamine Receptor (6)

FAK (6)

Antifungal (5)

Parasite (5)

Drug Metabolite (5)

Interleukin (5)

Influenza Virus (5)

IκB/IKK (5)

c-Fms (5)

SGK (5)

HIV Protease (4)

Estrogen/progestogen Receptor (4)

Phosphatase (4)

GTPase (4)

Virus Protease (4)

OCT (4)

Serine Protease (4)

Aryl Hydrocarbon Receptor (4)

Mitochondrial Metabolism (4)

HSV (4)

Trk receptor (4)

Hippo pathway (4)

TNF (4)

Sodium Channel (4)

Microtubule Associated (4)

Dopamine Receptor (3)

DNA Alkylator/Crosslinker (3)

Estrogen Receptor/ERR (3)

SIK (3)

RIP kinase (3)

ROS (3)

CaMK (3)

HSP (3)

MELK (3)

Retinoid Receptor (3)

Endogenous Metabolite (3)

PLK (3)

AChR (3)

Syk (3)

Tyrosinase (3)

ROS Kinase (3)

MLK (3)

Proteasome (2)

Carbonic Anhydrase (2)

HCV Protease (2)

Adenosine Receptor (2)

Na+/Ca2+ Exchanger (2)

c-Myc (2)

ABC (2)

Nucleoside Antimetabolite/Analog (2)

LIM Kinase (2)

PYK2 (2)

Caspase (2)

TRP/TRPV Channel (2)

MAO (2)

Glucocorticoid Receptor (2)

CSF-1R (2)

Topoisomerase (2)

Myosin (2)

GRK (2)

AAK1 (AP2 associated kinase 1) (2)

Reactive Oxygen Species (2)

Fatty Acid Synthase (2)

CCR (2)

ACK (2)

DUB (2)

Lipid (2)

MNK (2)

Antiviral (2)

Prostaglandin Receptor (2)

LRRK2 (2)

RSV (2)

KLF (2)

GPR (2)

CRISPR/Cas9 (2)

Phospholipase (2)

DAPK (2)

cholecystokinin (2)

HIF/HIF Prolyl-Hydroxylase (2)

Melanin-concentrating Hormone Receptor (MCHR) (1)

advanced glycation end products (1)

ATPase (1)

Chloride channel (1)

Adenylyl cyclase (1)

Transferase (1)

Antioxidant (1)

IFNAR (1)

RAAS (1)

Lipase (1)

Tie-2 (1)

VDA (1)

Progesterone Receptor (1)

MRP (1)

HBV (1)

Serotonin Transporter (1)

Cysteine Protease (1)

NAMPT (1)

Stemness kinase (1)

Immunology/Inflammation related (1)

Annexin A (1)

NMDAR (1)

MAGL (1)

DNA Alkylation (1)

Stearoyl-CoA Desaturase (SCD) (1)

PGC-1α (1)

IL Receptor (1)

PTEN (1)

MMP (1)

Epoxide Hydrolase (1)

GluR (1)

cAMP (1)

Thrombopoietin Receptor (1)

DNA (1)

Acyltransferase (1)

P-gp (1)

SARS-CoV (1)

Ephrin Receptor (1)

transporter (1)

Nrf2 (1)

PAI-1 (1)

Methionine Adenosyltransferase (MAT) (1)

Reverse Transcriptase (1)

Hydroxylase (1)

HIF (1)

NADPH-oxidase (1)

BMI-1 (1)

IRAK (1)

Sigma receptor (1)

TAM Receptor (1)

AhR (1)

NOD-like Receptor (NLR) (1)

NO Synthase (1)

S1P Receptor (1)

Monoamine Oxidase (1)

Kinesin (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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