细胞重编程化合物库

Reprogramming Compound Library

产品编号： L8110

细胞重编程指的是已分化的体细胞在一定条件下被逆转恢复到多能或全能性状态的过程。传统的重编程技术存在整合外源基因等问题在临床应用中存在局限性，而小分子化合物诱导多能干细胞的研究开辟了一条全新的体细胞重编程方法。小分子化合物诱导重编程的优点包括：不整合到基因组，无免疫原性；可以透过细胞膜直接作用于靶点，操作方便；效应可逆，可同时调控多个靶点，精确调控细胞命运。小分子化合物诱导的多能干细胞在药物发现、细胞治疗、疾病建模中具有很大的潜力，为治疗重大疾病开辟了新的途径。

TargetMol 细胞重编程化合物库是2240 种细胞重编程相关信号通路的生物活性小分子化合物的特有集合，为细胞重编程研究提供有效工具

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

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产品描述

2240种重编程信号通路相关的生物活性小分子化合物的特有集合，可用于高通量、高内涵筛选；
靶点含MEK、TGF-β、GSK3、wnt等；
结构多样，药效显著，可渗透细胞；
详细的说明书、化合物结构、靶点信息、IC50值、活性描述等；

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化合物库组成

Apoptosis (384)

Autophagy (298)

PI3K (195)

VEGFR (164)

EGFR (138)

JAK (125)

HDAC (124)

mTOR (107)

p38 MAPK (101)

Akt (98)

ERK (93)

Histone Methyltransferase (84)

Wnt/beta-catenin (84)

Epigenetic Reader Domain (83)

STAT (83)

PDGFR (82)

GSK-3 (81)

Raf (77)

AMPK (77)

FGFR (71)

Src (69)

CDK (65)

TGF-beta/Smad (64)

Endogenous Metabolite (62)

NF-κB (61)

c-Met/HGFR (59)

FLT (58)

c-Kit (57)

MAPK (54)

Ras (51)

JNK (49)

MEK (49)

PKC (48)

ROCK (48)

Antibacterial (43)

Nucleoside Antimetabolite/Analog (42)

Reactive Oxygen Species (42)

HIF/HIF Prolyl-Hydroxylase (40)

DNA-PK (38)

DNA/RNA Synthesis (36)

Kras (36)

Tyrosine Kinases (34)

S6 Kinase (31)

HER (30)

Monoamine Oxidase (30)

Bcr-Abl (29)

ALK (29)

Parasite (28)

Mitochondrial Metabolism (28)

Hedgehog/Smoothened (27)

ATM/ATR (27)

PKA (25)

c-RET (25)

HIF (24)

HIV Protease (22)

MAO (22)

COX (22)

PDK (22)

Aurora Kinase (21)

TNF (21)

Antibiotic (21)

Calcium Channel (20)

Mitophagy (19)

Sirtuin (19)

Influenza Virus (19)

Dehydrogenase (18)

TLR (18)

Caspase (17)

Casein Kinase (17)

c-Myc (16)

Pim (16)

Gamma-secretase (16)

Histone Acetyltransferase (16)

PERK (15)

PARP (15)

Rho (15)

IGF-1R (15)

Retinoid Receptor (15)

Potassium Channel (15)

P450 (14)

TAM Receptor (14)

Ferroptosis (13)

Virus Protease (13)

Smo (13)

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MMP (13)

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HCV Protease (8)

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Histone Demethylase (6)

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Antiviral (5)

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ASK (5)

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Serine Protease (4)

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LDL (4)

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NOS (3)

Dopamine Receptor (3)

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GTPase (3)

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PYK2 (3)

Aryl Hydrocarbon Receptor (3)

RIP kinase (3)

Antifection (3)

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transporter (3)

Cannabinoid Receptor (3)

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Beta-Secretase (2)

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KLF (2)

GPR (2)

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IRAK (2)

cholecystokinin (2)

PD-1/PD-L1 (2)

Apelin receptor (1)

Mdm2 (1)

NPC1L1 (1)

DHFR (1)

Dynamin (1)

Ligands for Target Protein for PROTAC (1)

YAP (1)

Arginase (1)

Na+/Ca2+ Exchanger (1)

Lipase (1)

gp120/CD4 (1)

Glutathione Peroxidase (1)

OCT (1)

ABC (1)

MRP (1)

Antifolate (1)

Glucocorticoid Receptor (1)

iGluR (1)

E1/E2/E3 Enzyme (1)

UGT (1)

AAK1 (AP2 associated kinase 1) (1)

NMDAR (1)

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MAGL (1)

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PAD (1)

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DUB (1)

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SGLT (1)

BCRP (1)

PGE Synthase (1)

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STING (1)

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hCE (1)

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GPX (1)

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RXFP receptor (1)

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DAPK (1)

Anti-infection (1)

BMI-1 (1)

Protease-activated Receptor (1)

p97 (1)

AhR (1)

NOD-like Receptor (NLR) (1)

CFTR (1)

Imidazoline Receptor (1)

Kinesin (1)

S1P Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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