ReFRAME 相关化合物库

ReFRAME Related Library

产品编号： L9230

2018年Jeff Janes 等人通过数据挖掘和文献查询，构建了ReFRAME 化合物库，在美国国家科学院院刊（PNAS）发表了关于ReFRAME 化合物库的应用和实用性；其中大部分已通过I 期临床研究具有临床安全性，ReFRAME 化合物库临床安全的独特性质将显著缩短候选药物进入临床的时间，降低失败风险，可高效应用于早期药物研发阶段的筛选以及先导化合物的发现。作者分享了ReFRAME 化合物库，旨在促进数据共享和药物发现机会。盖茨基金会和清华大学等创办的全球健康药物研发中心(GHDDI）也将ReFRAME 化合物库应用于抗COVID-19药物研发。

TargetMol 整理了ReFRAME 化合物库包含4080 种化合物，是药物再利用和抗COVID-19药物研发的有效工具。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

4080化合物的独特集合，可用于高通量筛选和高内涵筛选，是药物再利用和抗COVID-19药物研发的有效工具
部分化合物已上市得到FDA、EMA、NMPA等权威部门审批，大部分已通过I期临床研究;
通过结构多样性聚类分析，具有优良的结构多样性，包含2698个聚类簇（相似程度大于70%的为一簇），平均1.2个化合物一个簇；
涵盖多个研究领域：肿瘤、心血管药物、抗炎/免疫、神经系统药物、呼吸系统药物等；
靶点多样，包括5-HT Receptor、Sodium Channel、p38 MAPK、PI3K、MEK等；
详细的说明书，化合物结构、靶点信息、适应症信息、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Autophagy (388)

Apoptosis (374)

Antibacterial (325)

Antibiotic (297)

Endogenous Metabolite (236)

5-HT Receptor (177)

COX (128)

Adrenergic Receptor (125)

Dopamine Receptor (114)

Parasite (112)

AChR (103)

HIV Protease (99)

Antifungal (93)

Histamine Receptor (89)

DNA/RNA Synthesis (86)

Calcium Channel (82)

PDE (77)

Potassium Channel (77)

Sodium Channel (71)

VEGFR (63)

PI3K (61)

GABA Receptor (56)

PPAR (55)

Topoisomerase (54)

P450 (54)

Glucocorticoid Receptor (53)

Dehydrogenase (52)

HCV Protease (51)

Estrogen/progestogen Receptor (51)

Prostaglandin Receptor (49)

Reactive Oxygen Species (48)

EGFR (47)

Influenza Virus (46)

FLT (45)

RAAS (43)

Microtubule Associated (43)

SARS-CoV (42)

Ferroptosis (41)

JAK (41)

Adenosine Receptor (40)

CDK (39)

NF-κB (39)

PDGFR (35)

Nucleoside Antimetabolite/Analog (34)

HDAC (34)

FGFR (34)

c-Met/HGFR (32)

Mitophagy (32)

Estrogen Receptor/ERR (32)

c-Kit (32)

Src (31)

mTOR (31)

GPR (30)

p38 MAPK (29)

MAO (29)

Androgen Receptor (29)

iGluR (28)

HSV (27)

HBV (26)

TRP/TRPV Channel (26)

GluR (26)

Reverse Transcriptase (26)

Virus Protease (25)

Opioid Receptor (25)

ADC Cytotoxin (24)

Progesterone Receptor (24)

TNF (24)

ATPase (23)

PKC (23)

Proteasome (22)

Antioxidant (22)

NMDAR (22)

ROS (22)

HSP (22)

MEK (22)

Carbonic Anhydrase (21)

Bcr-Abl (21)

Aurora Kinase (21)

Lipoxygenase (21)

Akt (21)

Tyrosine Kinases (20)

Raf (20)

Antiviral (19)

Serotonin Transporter (18)

Antifection (18)

CCR (18)

IL Receptor (17)

MMP (17)

AChE (17)

Retinoid Receptor (17)

AMPK (17)

Thrombin (17)

HER (17)

DNA Alkylator/Crosslinker (16)

Phosphatase (16)

Endothelin Receptor (16)

Norepinephrine (16)

P-gp (16)

ALK (16)

Beta Amyloid (16)

Phospholipase (16)

Transferase (15)

Integrin (15)

LPL Receptor (15)

DPP-4 (15)

CXCR (15)

Epigenetic Reader Domain (15)

TLR (15)

STAT (15)

ribosome (15)

Monoamine Oxidase (15)

Thyroid hormone receptor(THR) (14)

Reductase (14)

PARP (14)

Caspase (14)

E1/E2/E3 Enzyme (14)

Gamma-secretase (14)

Mitochondrial Metabolism (14)

c-RET (14)

Cannabinoid Receptor (14)

HIF/HIF Prolyl-Hydroxylase (14)

S1P Receptor (14)

Proton pump (13)

Histone Methyltransferase (13)

ERK (13)

Drug Metabolite (13)

BTK (13)

BCL (13)

DNA Alkylation (13)

Acyltransferase (13)

DNA-PK (12)

Cysteine Protease (12)

SGLT (12)

Nrf2 (12)

Neurokinin receptor (12)

Syk (12)

NO Synthase (12)

DHFR (11)

PKA (11)

Hedgehog/Smoothened (11)

TGF-beta/Smad (11)

Trk receptor (11)

TAM Receptor (11)

Tyrosinase (11)

GSK-3 (10)

MRP (10)

FXR (10)

ROCK (10)

Guanylate cyclase (10)

Vasopressin Receptor (10)

Xanthine Oxidase (10)

CaMK (10)

Interleukin (10)

Aromatase (10)

Hydroxylase (10)

PLK (10)

HMG-CoA Reductase (10)

Sigma receptor (10)

CFTR (10)

Amino Acids and Derivatives (9)

Wnt/beta-catenin (9)

Serine Protease (9)

Leukotriene Receptor (9)

IGF-1R (9)

RSV (9)

HIF (9)

cholecystokinin (9)

p53 (9)

Chloride channel (8)

LTR (8)

NADPH (8)

CETP (8)

Glutathione Peroxidase (8)

Antifolate (8)

Vitamin (8)

Smo (8)

OX Receptor (8)

IκB/IKK (8)

ATM/ATR (8)

c-Fms (8)

Ras (8)

FAK (8)

JNK (7)

Factor Xa (7)

Serine/threonin kinase (7)

Glucokinase (7)

IAP (7)

DNA gyrase (7)

Chk (7)

Indoleamine 2,3-Dioxygenase (IDO) (7)

Platelet aggregation (7)

Mdm2 (6)

NOS (6)

P2Y Receptor (6)

ABC (6)

P2X Receptor (6)

Glucosidase (6)

FAAH (6)

Beta-Secretase (6)

Casein Kinase (6)

Ligand for E3 Ligase (6)

LPA Receptor (6)

CAT (5)

BACE (5)

Tie-2 (5)

Melatonin Receptor (5)

CaSR (5)

Rho (5)

Aryl Hydrocarbon Receptor (5)

IDO (5)

Immunology/Inflammation related (5)

CSF-1R (5)

Annexin A (5)

MT Receptor (5)

Monoamine Transporter (5)

PAK (5)

PGE Synthase (5)

Aminopeptidase (5)

Sirtuin (5)

NOD (5)

DNA Methyltransferase (5)

S6 Kinase (5)

ROS Kinase (5)

ROR (4)

UGT (4)

Molecular Glues (4)

Fatty Acid Synthase (4)

DNA (4)

Ephrin Receptor (4)

PAI-1 (4)

Acetyl-CoA Carboxylase (4)

Kras (4)

PDK (4)

GHSR (4)

Adenosine deaminase (4)

Complement System (4)

Anti-infection (4)

NOD-like Receptor (NLR) (4)

AhR (4)

Imidazoline Receptor (4)

Monocarboxylate transporter (3)

CRM1 (3)

Arginase (3)

IFNAR (3)

Na+/Ca2+ Exchanger (3)

GNRH Receptor (3)

Pim (3)

Liver X Receptor (3)

NAMPT (3)

IRE1 (3)

Myosin (3)

PAFR (3)

Glucagon Receptor (3)

GlyT (3)

Hexokinase (3)

Isocitrate Dehydrogenase (IDH) (3)

HCN Channel (3)

Bradykinin Receptor (3)

Epoxide Hydrolase (3)

Mucin (3)

BCRP (3)

OAT (3)

STING (3)

transporter (3)

Decarboxylase (3)

CRFR (3)

Neprilysin (3)

Oxytocin Receptor (3)

Protease-activated Receptor (3)

Kinesin (3)

advanced glycation end products (2)

Adenylyl cyclase (2)

DprE1 (2)

Ligands for Target Protein for PROTAC (2)

Histone Demethylase (2)

Galectin (2)

c-Myc (2)

FLAP (2)

RIP kinase (2)

Na-K-Cl cotransporter (2)

Neuropeptide Y Receptor (2)

Stearoyl-CoA Desaturase (SCD) (2)

Angiotensin-converting Enzyme (ACE) (2)

Somatostatin (2)

KSP (2)

cAMP (2)

Thrombopoietin Receptor (2)

DUB (2)

Telomerase (2)

ATP Citrate Lyase (2)

Lipid (2)

Wee1 (2)

Glutathione reductase (2)

MAPK (2)

Porcupine (2)

Free radical scavengers (2)

GPCR19 (2)

GluCls (2)

Melanocortin Receptor (2)

CRISPR/Cas9 (2)

CGRP Receptor (2)

SGK (2)

Gap Junction Protein (2)

Discoidin Domain Receptor (DDR) (2)

NADPH-oxidase (2)

Melanin-concentrating Hormone Receptor (MCHR) (1)

Taste receptor (1)

PROTACs (1)

GSNOR (1)

NPC1L1 (1)

Hydrogenase (1)

MALT (1)

NEDD8 (1)

YAP (1)

Procollagen C Proteinase (1)

RAR/RXR (1)

Cell wall (1)

Lipase (1)

PERK (1)

gp120/CD4 (1)

TOPK (1)

VDA (1)

N-Acetylglucosaminyltransferase (1)

VDAC (1)

Hck (1)

cell cycle arrest (1)

Neurotensin Receptor (1)

PYK2 (1)

Glutaminase (1)

Prolyl Endopeptidase (PREP) (1)

LDL (1)

Phosphorylase (1)

Anion Exchanger (1)

Thioredoxin (1)

PAD (1)

ACK (1)

Survivin (1)

MNK (1)

LRRK2 (1)

Histone Acetyltransferase (1)

ASK (1)

Pyroptosis (1)

Methionine Adenosyltransferase (MAT) (1)

GST (1)

Carboxypeptidase (1)

GPX (1)

Protease (1)

PI4K (1)

KLF (1)

IRAK (1)

lysosomal autophagy (1)

p97 (1)

PD-1/PD-L1 (1)

PKM (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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