蛋白酶抑制剂库

Protease Inhibitor Library

产品编号： L1100

蛋白酶抑制剂包括蛋白质类蛋白酶抑制剂和其他天然小分子类蛋白酶抑制剂，具有多种生物活性：（1）抗病虫害侵袭。蛋白酶抑制剂可以与昆虫体内消化道中的蛋白酶作用形成酶-抑制剂复合物，干扰其正常代谢进而导致其死亡。（2）免疫调节与抗炎作用。蛋白酶抑制剂具有免疫调节特性。蛋白酶抑制剂也可抑制与炎症有关的蛋白酶如组织蛋白酶 G 和弹性蛋白酶等而发挥抗炎作用。（3）抗氧化作用。蛋白酶抑制剂能通过抑制炎症反应而降低自由基的产生。多酚类化合物还具有直接和间接清除自由基的能力，表现出广泛的抗氧化作用。（4）抑制肿瘤作用。蛋白酶抑制剂能抑制蛋白质的水解而限制肿瘤生长所需的过量氨基酸；阻止癌细胞的侵袭和转移；抑制肿瘤血管新生，影响肿瘤细胞生长，并诱导肿瘤细胞凋亡。（5）保护心血管作用。一氧化氮是调节血管平滑肌收缩的关键分子。蛋白酶抑制剂能促进一氧化氮的释放而对心血管系统起保护作用。

TargetMol 蛋白酶抑制剂库是 507 种已知的小分子蛋白酶抑制剂的集合，可用于化学基因组学相关研究和药物筛选。

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产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

507种已知的小分子蛋白酶抑制剂的特有集合，可用于高通量筛选和高内涵筛选；
靶点含Proteasome、DPP-4、Serine Protease、Cysteine Protease、MMP、Aspartic proteinases等；
通过前期临床研究和临床实验，生物活性和安全性已经得到验证；
其中一些活性化合物已得到FDA批准上市；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR和HPLC检测技术保证产品高纯度和高质量；
所有化合物现货供应。

化合物库定制

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化合物库咨询

化合物库组成

MMP (86)

Caspase (80)

Proteasome (66)

Apoptosis (64)

Gamma-secretase (44)

Virus Protease (42)

Cysteine Protease (42)

Serine Protease (39)

Autophagy (38)

SARS-CoV (38)

HIV Protease (30)

DPP-4 (29)

Thrombin (29)

Antibacterial (20)

HCV Protease (18)

BCL (16)

Endogenous Metabolite (16)

PARP (14)

NF-κB (12)

p38 MAPK (11)

Parasite (10)

Beta Amyloid (10)

COX (9)

Reactive Oxygen Species (8)

JAK (7)

IL Receptor (7)

Akt (7)

Carboxypeptidase (7)

Protease (7)

P450 (7)

TNF (7)

Antibiotic (7)

Antifungal (6)

JNK (6)

Serine/threonin kinase (6)

ERK (6)

Antiviral (6)

PI3K (5)

PPAR (5)

Immunology/Inflammation related (5)

HSV (5)

P-gp (5)

Influenza Virus (5)

Dehydrogenase (4)

Ferroptosis (4)

Antioxidant (4)

Factor Xa (4)

ROS (4)

DUB (4)

DNA/RNA Synthesis (4)

Estrogen/progestogen Receptor (3)

BACE (3)

TRP/TRPV Channel (3)

PKC (3)

CDK (3)

Drug Metabolite (3)

Lipoxygenase (3)

Interleukin (3)

Prostaglandin Receptor (3)

Nrf2 (3)

STAT (3)

HDAC (3)

5-HT Receptor (3)

GABA Receptor (3)

HIF/HIF Prolyl-Hydroxylase (3)

NO Synthase (3)

Histamine Receptor (2)

Phosphatase (2)

Mitophagy (2)

Wnt/beta-catenin (2)

Rho (2)

Calcium Channel (2)

IAP (2)

Thrombopoietin Receptor (2)

Epigenetic Reader Domain (2)

mTOR (2)

Beta-Secretase (2)

MAPK (2)

Free radical scavengers (2)

PAI-1 (2)

Pyroptosis (2)

ATM/ATR (2)

ribosome (2)

AMPK (2)

Phospholipase (2)

Potassium Channel (2)

AChR (2)

Anti-infection (2)

DNA Methyltransferase (2)

Tyrosinase (2)

NOD-like Receptor (NLR) (2)

p53 (2)

ATPase (1)

Proton pump (1)

Carbonic Anhydrase (1)

ROR (1)

Dopamine Receptor (1)

DNA-PK (1)

Src (1)

Dynamin (1)

Amino Acids and Derivatives (1)

gp120/CD4 (1)

GSK-3 (1)

PKA (1)

Nucleoside Antimetabolite/Analog (1)

Adrenergic Receptor (1)

MAO (1)

E1/E2/E3 Enzyme (1)

UGT (1)

PAFR (1)

NMDAR (1)

BTK (1)

Antifection (1)

Opioid Receptor (1)

Fatty Acid Synthase (1)

Somatostatin (1)

Aurora Kinase (1)

cAMP (1)

IGF-1R (1)

CaMK (1)

DNA (1)

TLR (1)

STING (1)

Aminopeptidase (1)

AIM2 (1)

ALK (1)

IκB/IKK (1)

Neprilysin (1)

PI4K (1)

GPR (1)

Complement System (1)

Platelet aggregation (1)

Sodium Channel (1)

Ras (1)

Protease-activated Receptor (1)

FAK (1)

CFTR (1)

S1P Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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