PPI抑制剂库 | TargetMol

PPI Inhibitor Library

产品编号： L9400

蛋白-蛋白相互作用（PPI）在生物过程中扮有非常重要的角色，是生物信息调控的主要实现方式，并且与人类疾病息息相关。在传统药物的作用中，药物靶标通常为酶或受体，而蛋白-蛋白相互作用为我们展示了一类新的、重要的疾病治疗切入点。目前，作用于蛋白-蛋白相互作用小分子抑制剂的研究已经取得了一些进展，其中有的化合物已被应用于临床研究。同时随着越来越多的蛋白-蛋白复合物晶体结构的解析，将为新型小分子抑制剂的发现奠定基础。

TaregtMol PPI 抑制剂库收集了 485 种已知活性的 PPI 相关的抑制剂，可以用于蛋白-蛋白相互作用相关的研究。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

485种已知活性的PPI相关的抑制剂，可用于高通量、高内涵筛选；
作用靶点包含PD-1/PD-L1、Bcl-2、BET bromodomain、BRD4 bromodomain等；
详细的说明书，化合物结构、靶点信息、活性描述等；
NMR、HPLC/ LCMS多重检测，保证产品结构准确，纯度高，保障实验顺利进行。

化合物库定制

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化合物库组成

Epigenetic Reader Domain (109)

Apoptosis (55)

BCL (43)

p53 (24)

Mdm2 (23)

Autophagy (22)

HIV Protease (20)

E1/E2/E3 Enzyme (19)

Histone Methyltransferase (16)

Nrf2 (15)

PD-1/PD-L1 (13)

PROTACs (11)

RIP kinase (10)

IAP (9)

Ferroptosis (8)

Wnt/beta-catenin (8)

Ras (8)

DNA/RNA Synthesis (7)

Histone Acetyltransferase (7)

c-Myc (6)

Rho (5)

CDK (5)

Raf (5)

Sirtuin (5)

NF-κB (5)

Microtubule Associated (5)

Integrin (4)

Caspase (4)

Endogenous Metabolite (4)

Ligands for Target Protein for PROTAC (3)

YAP (3)

Dehydrogenase (3)

PERK (3)

CXCR (3)

COX (3)

PSMA (3)

HSP (3)

Ligand for E3 Ligase (3)

HIF (3)

TNF (3)

Dopamine Receptor (2)

DNA-PK (2)

Src (2)

NEDD8 (2)

DNA Alkylator/Crosslinker (2)

IFNAR (2)

GTPase (2)

Phosphatase (2)

GSK-3 (2)

PPAR (2)

Parasite (2)

Aryl Hydrocarbon Receptor (2)

iGluR (2)

NMDAR (2)

Integrase (2)

IL Receptor (2)

mTOR (2)

Antibacterial (2)

Carboxypeptidase (2)

Reverse Transcriptase (2)

STAT (2)

Kras (2)

Sodium Channel (2)

HIF/HIF Prolyl-Hydroxylase (2)

Chloride channel (1)

ATPase (1)

Proton pump (1)

NPC1L1 (1)

MyD88 (1)

p38 MAPK (1)

Estrogen/progestogen Receptor (1)

Antifungal (1)

PI3K (1)

Antioxidant (1)

RAAS (1)

Histamine Receptor (1)

JNK (1)

Glutathione Peroxidase (1)

Mitophagy (1)

Estrogen Receptor/ERR (1)

PARP (1)

Serotonin Transporter (1)

Serine/threonin kinase (1)

Cysteine Protease (1)

Liver X Receptor (1)

Neurotensin Receptor (1)

FXR (1)

Glucokinase (1)

Calcium Channel (1)

PKC (1)

ERK (1)

MAO (1)

Topoisomerase (1)

Myosin (1)

PDE (1)

Gamma-secretase (1)

Mitochondrial Metabolism (1)

Molecular Glues (1)

Reactive Oxygen Species (1)

JAK (1)

CCR (1)

GluR (1)

IGF-1R (1)

DNA (1)

Androgen Receptor (1)

Interleukin (1)

TGF-beta/Smad (1)

Akt (1)

MNK (1)

TLR (1)

SARS-CoV (1)

STING (1)

GPCR19 (1)

Ephrin Receptor (1)

transporter (1)

HuR (1)

IκB/IKK (1)

Beta Amyloid (1)

Retinoid Receptor (1)

HDAC (1)

5-HT Receptor (1)

PLK (1)

Potassium Channel (1)

Neurokinin receptor (1)

Discoidin Domain Receptor (DDR) (1)

HMG-CoA Reductase (1)

Tyrosinase (1)

Thrombin (1)

Antibiotic (1)

FAK (1)

AhR (1)

MLK (1)

Monoamine Oxidase (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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