PI3K/Akt/mTOR 化合物库

PI3K-AKT-mTOR Compound Library

产品编号： L1300

PI3K / AKT / mTOR 信号传导通路是调节细胞周期非常重要的一条通路，在细胞生长、存活、增殖、凋亡、血管生成、自吞噬等过程中发挥着极其重要的生物学功能。该通路由PI3激酶（PI3K ）、蛋白激酶B（Akt）和哺乳动物类雷帕霉素靶蛋白（mTor）三个作用分子组成， PI3K 活化后，通过PIP3 的作用，磷酸化并激活Akt，Akt 可以有许多下游效应，如激活CREB，抑制p27，在细胞质中定位FOXO，激活PtdIns-3ps。mTOR 已经被确定是PI3K/Akt 下游一个重要靶点，是自噬调节中研究较多的靶蛋白之一，是调控肿瘤细胞自噬经典的通路。因此该通路被广泛地研究并开发新的抗肿瘤制剂，mTOR 的抑制剂对于多种肿瘤的治疗已取得了很好的研究结果。 PI3K/Akt/mTOR 化合物库是610 个与PI3K/Akt/mTOR 信号通路相关的小分子化合物的独特集合，可用于高通量、高内涵筛选；

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产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

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产品描述

610种与PI3K/Akt/mTOR相关的生物活性小分子化合物的特有集合，用于PI3K/Akt/mTOR相关研究以及高通量、高内涵筛选；
是研究细胞及肿瘤细胞生长、增殖、凋亡的有效工具；
靶点含Akt、AMPK、mTOR、PI3K、ATR/ATM等；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

PI3K (211)

mTOR (117)

Apoptosis (113)

Akt (111)

Autophagy (96)

AMPK (87)

GSK-3 (85)

DNA-PK (38)

CDK (37)

S6 Kinase (33)

ATM/ATR (30)

PDK (23)

ERK (19)

Endogenous Metabolite (16)

Antibacterial (15)

PI4K (14)

NF-κB (14)

Src (11)

PKA (11)

PKC (11)

VEGFR (10)

Caspase (10)

p38 MAPK (9)

JNK (9)

Wnt/beta-catenin (9)

Parasite (9)

STAT (9)

Mitophagy (8)

SIK (8)

Reactive Oxygen Species (8)

PTEN (8)

Chk (8)

MEK (8)

PPAR (7)

COX (7)

MAPK (7)

Casein Kinase (7)

TNF (7)

FLT (7)

HIV Protease (6)

Dehydrogenase (6)

ROCK (6)

MELK (6)

Antibiotic (6)

JAK (5)

IL Receptor (5)

Aurora Kinase (5)

P450 (5)

DYRK (4)

Phosphatase (4)

Calcium Channel (4)

Bcr-Abl (4)

BCL (4)

MMP (4)

IGF-1R (4)

Influenza Virus (4)

HDAC (4)

Potassium Channel (4)

PARP (3)

PDE (3)

Raf (3)

Antifection (3)

PDGFR (3)

HSV (3)

Lipoxygenase (3)

Interleukin (3)

DNA/RNA Synthesis (3)

Nrf2 (3)

FGFR (3)

SGK (3)

AChR (3)

Microtubule Associated (3)

FAK (3)

Carbonic Anhydrase (2)

HCV Protease (2)

ADC Cytotoxin (2)

Integrin (2)

Antioxidant (2)

Adenosine Receptor (2)

BACE (2)

Virus Protease (2)

Pim (2)

Rho (2)

Serine/threonin kinase (2)

Adrenergic Receptor (2)

Gamma-secretase (2)

Glucosidase (2)

Mitochondrial Metabolism (2)

Epigenetic Reader Domain (2)

TGF-beta/Smad (2)

EGFR (2)

Beta-Secretase (2)

AChE (2)

P-gp (2)

Prostaglandin Receptor (2)

transporter (2)

IκB/IKK (2)

Beta Amyloid (2)

PLK (2)

HIF (2)

c-RET (2)

Cannabinoid Receptor (2)

c-Kit (2)

p53 (2)

Chloride channel (1)

ATPase (1)

NOS (1)

NPC1L1 (1)

Dopamine Receptor (1)

Estrogen/progestogen Receptor (1)

YAP (1)

Ferroptosis (1)

Antifungal (1)

c-Met/HGFR (1)

RAR/RXR (1)

NADPH (1)

PERK (1)

RAAS (1)

Tie-2 (1)

gp120/CD4 (1)

GTPase (1)

MRP (1)

HBV (1)

Estrogen Receptor/ERR (1)

Tyrosine Kinases (1)

Serine Protease (1)

Hck (1)

FXR (1)

Glucokinase (1)

PYK2 (1)

TRP/TRPV Channel (1)

Aryl Hydrocarbon Receptor (1)

Topoisomerase (1)

Myosin (1)

E1/E2/E3 Enzyme (1)

RIP kinase (1)

LDL (1)

Monoamine Transporter (1)

Opioid Receptor (1)

Fatty Acid Synthase (1)

GluR (1)

cAMP (1)

CaMK (1)

ATP Citrate Lyase (1)

BCRP (1)

Acyltransferase (1)

Antiviral (1)

TLR (1)

LRRK2 (1)

Trk receptor (1)

Sirtuin (1)

Decarboxylase (1)

ALK (1)

c-Fms (1)

CRISPR/Cas9 (1)

GABA Receptor (1)

DAPK (1)

Syk (1)

NOD (1)

cholecystokinin (1)

Tyrosinase (1)

HIF/HIF Prolyl-Hydroxylase (1)

Kinesin (1)

S1P Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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