活血化瘀中药单体库

PBCRBS Traditional Chinese Medicine Compound Library

产品编号： L6750

活血化瘀 (Promoting blood circulation for removing blood stasis,PBCRBS) 是中医学的一个重要理论和治疗原则，《皇帝内经》记载的“疏其血气、令其调达”，“血实宜决之”，“苑陈则除之者，出恶血也”，已成为活血化瘀治则的理论基础。常见的活血化瘀中药有川芎、姜黄、桃仁、红花、赤芍、丹参、乳香、没药等，这类中药药性多为辛、苦、温，故能行血活血、消散瘀滞。现代药理学研究表明活血化瘀中药具有改善血流动力学异常、改善血液流变学异常、改善微循环障碍、抗血栓形成、抗动脉粥样硬化及心肌缺血、抑制组织异常增生、抑制肿瘤和镇痛等作用，被广泛用于治疗包括心脑血管疾病、糖尿病、肝硬化等疾病，且临床疗效显著，展现出良好的应用前景。

中药具有多成分、多靶点的特性，单一中药的活性成分多样，且功能不同，同一活性成分可以影响多条通路，例如姜黄的活性成分姜黄素可以通过影响白细胞介素-17（IL-17）信号通路治疗大鼠的心房颤动（AF）；还可通过激活环AMP 反应元件结合蛋白（CREB）/脑源性神经营养因子（BDNF）信号通路发挥大鼠神经保护作用。

为研究活血化瘀中药发挥药理作用的主要成分以及这些成分的作用机制。TargetMol活血化瘀中药单体库收集了1072种来源于常见活血化瘀中药的单体化合物，是药物开发、药理研究等领域的有效工具。

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产品描述

1072种来源于活血化瘀中药的单体化合物集合，是药物开发、药理研究等领域的有效工具；
来源包括红花、莪术、姜黄、急性子、丹参、没药等40多种具有活血化瘀功效的中药；
结构多样性，包含萜类、生物碱、黄酮类等结构化合物；
提供详细的化合物说明书，包括化合物结构、靶点信息以及活性描述等；
严格的品控，NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。
提供化合物库使用说明，包括产品处理、溶剂选择、存储方式以及初筛浓度选择。

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化合物库组成

Endogenous Metabolite (213)

Apoptosis (146)

Autophagy (88)

Antibacterial (85)

NF-κB (68)

Antioxidant (64)

Reactive Oxygen Species (52)

Antifungal (44)

COX (41)

P450 (30)

Influenza Virus (27)

Parasite (26)

HIV Protease (20)

TNF (20)

NO Synthase (20)

ROS (19)

AChE (18)

PPAR (17)

ERK (17)

IL Receptor (17)

p38 MAPK (16)

Caspase (16)

GABA Receptor (16)

Immunology/Inflammation related (15)

DNA/RNA Synthesis (15)

Nrf2 (14)

Anti-infection (14)

PI3K (13)

Virus Protease (13)

MMP (12)

Akt (12)

Tyrosinase (12)

Antibiotic (12)

Mitophagy (11)

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Microtubule Associated (1)

FAK (1)

ROS Kinase (1)

AhR (1)

NOD-like Receptor (NLR) (1)

PKM (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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