口服活性化合物库

Orally Active Compound Library

产品编号： L9850

口服给药是临床给药尤其是长期用药的常用给药方式，也是安全、方便、经济的给药方法；口服生物利用度是药物经胃肠道黏膜吸收，经过肝脏进入体循环血液中的药量占口服剂量的百分比；口服生物利用度高的药物，较低剂量即可达到疗效，有效降低毒副作用；而口服生物利用度过低时，药理活性好的化合物也无法在靶部位充分的暴露，由此造成治疗的失败或者剂量过高产生较大的毒副作用，导致药物开发失败，限制了应用。 TargetMol 精心收集了 3160 种公开报道具有口服活性的化合物，可以用于药物再利用及口服活性药物的开发。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

3160种口服活性化合物独特集合，可用于高通量筛选和高内涵筛选；
部分药物已批准上市或处于临床试验中，生物活性和安全性得到验证；
详细的说明书，化合物结构、靶点信息、活性描述等；
NMR和HPLC检测技术保证产品高纯度；
所有化合物现货供应。

化合物库定制

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化合物库组成

Autophagy (305)

Apoptosis (294)

Antibacterial (225)

Antibiotic (205)

5-HT Receptor (158)

Endogenous Metabolite (114)

Adrenergic Receptor (111)

Histamine Receptor (105)

Dopamine Receptor (100)

COX (88)

AChR (82)

HIV Protease (72)

Parasite (68)

DNA/RNA Synthesis (61)

VEGFR (59)

Potassium Channel (58)

EGFR (57)

Sodium Channel (56)

PDE (54)

Calcium Channel (52)

SARS-CoV (51)

Estrogen/progestogen Receptor (48)

CDK (48)

Cytochromes P450 (48)

Glucocorticoid Receptor (45)

PDGFR (45)

FLT (44)

Dehydrogenase (43)

c-Kit (40)

RAAS (39)

Antifungal (35)

PI3K (35)

Estrogen Receptor/ERR (35)

HCV Protease (34)

Topoisomerase (33)

JAK (33)

Src (32)

FGFR (32)

Ferroptosis (31)

Reactive Oxygen Species (31)

Microtubule Associated (30)

PPAR (29)

BTK (29)

Mitophagy (28)

c-Met/HGFR (27)

HBV (27)

Bcr-Abl (27)

Reverse Transcriptase (27)

NF-κB (27)

p38 MAPK (26)

Serotonin Transporter (26)

GluR (26)

GABA Receptor (26)

TRP/TRPV Channel (25)

Androgen Receptor (25)

Prostaglandin Receptor (25)

Influenza Virus (25)

Proteasome (24)

iGluR (24)

Epigenetic Reader Domain (24)

HDAC (24)

GPR (24)

Histone Methyltransferase (23)

Norepinephrine (23)

Phosphatase (22)

Raf (22)

Adenosine Receptor (21)

Tyrosine Kinases (21)

Cholinesterase (ChE) (21)

mTOR (21)

ALK (21)

Progesterone Receptor (20)

HER (19)

PARP (18)

ROS (18)

Transferase (17)

ERK (17)

Opioid Receptor (17)

MMP (17)

MAPK (17)

Antiviral (17)

ribosome (17)

TNF (17)

Integrin (16)

GSK-3 (16)

DPP-4 (16)

HSV (16)

Kras (16)

Thrombin (16)

HIF/HIF Prolyl-Hydroxylase (16)

S1P Receptor (16)

Proton pump (15)

LPL Receptor (15)

Factor Xa (15)

Nucleoside Antimetabolite/Analog (15)

NMDAR (15)

P-gp (15)

Trk receptor (15)

Beta Amyloid (15)

MEK (15)

Virus Protease (14)

Retinoid Receptor (14)

STAT (14)

c-Fms (14)

c-RET (14)

Syk (14)

Monoamine Oxidase (14)

ROCK (13)

MAO (13)

Mitochondrial Metabolism (13)

Endothelin Receptor (13)

Aurora Kinase (13)

Lipoxygenase (13)

SGLT (13)

Akt (13)

TAM Receptor (13)

Carbonic Anhydrase (12)

ADC Cytotoxin (12)

Reductase (12)

MRP (12)

CCR (12)

CXCR (12)

HSP (12)

Phospholipase (12)

Cannabinoid Receptor (12)

Thyroid hormone receptor(THR) (11)

ATPase (11)

Wnt/beta-catenin (11)

Gamma-secretase (11)

DNA gyrase (11)

Fatty Acid Synthase (11)

IL Receptor (11)

Interleukin (11)

Acyltransferase (11)

ROS Kinase (11)

DHFR (10)

PKC (10)

CSF-1R (10)

ATM/ATR (10)

AMPK (10)

ROR (9)

NADPH (9)

Caspase (9)

Glucagon Receptor (9)

P2X Receptor (9)

Guanylate cyclase (9)

IGF-1R (9)

TGF-beta/Smad (9)

TLR (9)

Neurokinin receptor (9)

HMG-CoA Reductase (9)

CFTR (9)

NO Synthase (9)

Antioxidant (8)

Histone Demethylase (8)

Glutathione Peroxidase (8)

PKA (8)

E1/E2/E3 Enzyme (8)

ABC Transporter (8)

Antifection (8)

Hedgehog/Smoothened (8)

Bcl-2 Family (8)

RSV (8)

PLK (8)

Complement System (8)

FAK (8)

P2Y Receptor (7)

LTR (7)

Serine/threonin kinase (7)

Cysteine Protease (7)

FXR (7)

Leukotriene Receptor (7)

Vasopressin Receptor (7)

OX Receptor (7)

Xanthine Oxidase (7)

CaMK (7)

Beta-Secretase (7)

Aminopeptidase (7)

Nrf2 (7)

Ligand for E3 Ligase (7)

Aromatase (7)

Hydroxylase (7)

HIF (7)

IRAK (7)

Sigma receptor (7)

Mdm2 (6)

DNA Alkylator/Crosslinker (6)

BACE (6)

PERK (6)

GNRH Receptor (6)

Pim (6)

Antifolate (6)

IAP (6)

Smo (6)

Indoleamine 2,3-Dioxygenase (IDO) (6)

transporter (6)

ASK (6)

Casein Kinase (6)

GHSR (6)

DNA Methyltransferase (6)

Ras (6)

PD-1/PD-L1 (6)

NOS (5)

DNA-PK (5)

YAP (5)

Lipase (5)

Melatonin Receptor (5)

Serine Protease (5)

Aryl Hydrocarbon Receptor (5)

Isocitrate Dehydrogenase (IDH) (5)

DNA Alkylation (5)

PAK (5)

Stearoyl-CoA Desaturase (SCD) (5)

Chk (5)

Ephrin Receptor (5)

IκB/IKK (5)

NADPH-oxidase (5)

p53 (5)

CRM1 (4)

Vitamin (4)

Drug Metabolite (4)

MT Receptor (4)

Monoamine Transporter (4)

Neuropeptide Y Receptor (4)

FAAH (4)

DNA (4)

DUB (4)

PGE Synthase (4)

Porcupine (4)

PAI-1 (4)

Neprilysin (4)

cholecystokinin (4)

Protease-activated Receptor (4)

AhR (4)

Monocarboxylate transporter (3)

Amino Acids and Derivatives (3)

IFNAR (3)

CETP (3)

JNK (3)

CaSR (3)

Liver X Receptor (3)

Glucokinase (3)

Annexin A (3)

FLAP (3)

RIP kinase (3)

UGT (3)

GlyT (3)

Glucosidase (3)

Hexokinase (3)

Molecular Glues (3)

PAD (3)

Epoxide Hydrolase (3)

Thrombopoietin Receptor (3)

Mucin (3)

OXPHOS (3)

Free radical scavengers (3)

Sirtuin (3)

GST (3)

LPA Receptor (3)

PI4K (3)

Oxytocin Receptor (3)

CGRP Receptor (3)

Discoidin Domain Receptor (DDR) (3)

NOD (3)

S6 Kinase (3)

NOD-like Receptor (NLR) (3)

Melanin-concentrating Hormone Receptor (MCHR) (2)

Advanced Glycation End Products (2)

PROTACs (2)

MALT (2)

NEDD8 (2)

Ligands for Target Protein for PROTAC (2)

Sodium-dependent phosphate transporter (2)

Cell wall (2)

Tie-2 (2)

TOPK (2)

Rho (2)

Hck (2)

Glutaminase (2)

IDO (2)

SIK (2)

IRE1 (2)

PAFR (2)

Na-K-Cl cotransporter (2)

Integrase (2)

Bradykinin Receptor (2)

Telomerase (2)

Lipid (2)

MNK (2)

OAT (2)

STING (2)

LRRK2 (2)

Histone Acetyltransferase (2)

GluCls (2)

Hippo pathway (2)

Acetyl-CoA Carboxylase (2)

PDK (2)

Adenosine Deaminase (2)

SGK (2)

Platelet aggregation (2)

BMI-1 (2)

Tyrosinase (2)

MLK (2)

Imidazoline Receptor (2)

Kinesin (2)

Chloride channel (1)

Taste receptor (1)

GSNOR (1)

NPC1L1 (1)

Hydrogenase (1)

CD38 (1)

Arginase (1)

Na+/Ca2+ Exchanger (1)

DYRK (1)

Necroptosis (1)

GTPase (1)

OCT (1)

Galectin (1)

c-Myc (1)

AAK1 (1)

Neurotensin Receptor (1)

NAMPT (1)

PYK2 (1)

FOXO1 (1)

Prolyl Endopeptidase (PREP) (1)

Myosin (1)

Adiponectin Receptor (1)

Haspin Kinase (1)

LDL (1)

GRK (1)

PACAP (1)

PROTAC Linker (1)

HCN Channel (1)

ACK1 (1)

Angiotensin-converting Enzyme (ACE) (1)

Somatostatin (1)

cAMP (1)

ATP Citrate Lyase (1)

Wee1 (1)

BCRP (1)

Glutathione reductase (1)

Survivin (1)

GPCR19 (1)

Decarboxylase (1)

Pyroptosis (1)

Methionine Adenosyltransferase (MAT) (1)

GPX (1)

Melanocortin Receptor (1)

CRISPR/Cas9 (1)

RXFP receptor (1)

Gap Junction Protein (1)

Anti-infection (1)

p97 (1)

PKM (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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