NF-κB 通路分子库

NF-κB Signaling Compound Library

产品编号： L3800

NF-κB 为一个转录因子蛋白家族，包括5个亚单位，两个亚单位形成的同源或异源二聚体与靶基因上特定的序列结合调节基因转录，不同的 NF-κB 二聚体在选择结合序列时可能略有差异，这是 NF-κB 通过不同的二聚体形式对不同基因的表达进行精细调节的一种方式。在静息的细胞中，NF-κB 和 IκB 形成复合体，以无活性形式存在于胞浆中。当细胞受细胞外信号刺激后，IκB 激酶（IκB kinase, IKK）将 IκB 磷酸化，使NF-κB 暴露核定位位点。游离的NF-κB 迅速移位到细胞核，与特异性序列结合，诱导相关基因转录。参与免疫反应的早期和炎症反应各阶段的许多分子都受NF-κB 的调控，包括：TNF-α、IL-1β、IL-2、IL-6、IL-8、IL-12、趋化因子、粘附分子、集落刺激因子等。此外，与细胞凋亡有关的分子如：肿瘤坏死因子受体相关因子-1（TRAF-1），抗细胞凋亡的蛋白-1和-2（IAP1/ IAP2），TNF 受体相关因子（TRAF）也都受NF-κB 的调控。

TargetMol NF-κB 信号通路分子库是由729 个NF-κB 信号通路相关的小分子化合物组成的独特集合，用于NF-κB 信号通路相关的研究及药物的筛选，可用于高通量、高内涵筛选。

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产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

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产品描述

729 个NF-κB信号通路相关的小分子化合物的特有集合，用于高通量、高内涵筛选；
是NF-κB信号通路研究及相关药物筛选的有效工具；??
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

NF-κB (80)

Reactive Oxygen Species (71)

TNF (54)

Apoptosis (43)

IκB/IKK (41)

RIP kinase (35)

NOD (25)

IRAK (22)

Autophagy (19)

IL Receptor (15)

Antibacterial (12)

COX (11)

MAPK (9)

TLR (9)

NOD-like Receptor (NLR) (9)

Antioxidant (8)

Endogenous Metabolite (8)

Ferroptosis (7)

Interleukin (7)

CDK (6)

p38 MAPK (5)

Mitochondrial Metabolism (5)

ROS (5)

Ligand for E3 Ligase (5)

Calcium Channel (4)

TRP/TRPV Channel (4)

ERK (4)

E1/E2/E3 Enzyme (4)

Molecular Glues (4)

EGFR (4)

Antibiotic (4)

Proteasome (3)

Estrogen/progestogen Receptor (3)

Dehydrogenase (3)

Antifungal (3)

Parasite (3)

PDE (3)

mTOR (3)

Akt (3)

DNA/RNA Synthesis (3)

Nrf2 (3)

Potassium Channel (3)

AChR (3)

Sodium Channel (3)

p53 (3)

LTR (2)

IFNAR (2)

NADPH (2)

Histamine Receptor (2)

JNK (2)

Phosphatase (2)

PPAR (2)

MAO (2)

BTK (2)

GluR (2)

Antiviral (2)

HSP (2)

STING (2)

Free radical scavengers (2)

Sirtuin (2)

AIM2 (2)

STAT (2)

Phospholipase (2)

MEK (2)

FGFR (2)

Mdm2 (1)

Chloride channel (1)

HIV Protease (1)

ATPase (1)

NOS (1)

MALT (1)

Src (1)

MyD88 (1)

c-Met/HGFR (1)

BACE (1)

DYRK (1)

Histone Demethylase (1)

RAAS (1)

Necroptosis (1)

Glutathione Peroxidase (1)

Mitophagy (1)

c-Myc (1)

Estrogen Receptor/ERR (1)

Tyrosine Kinases (1)

Wnt/beta-catenin (1)

PARP (1)

Pim (1)

Rho (1)

Serine Protease (1)

Serine/threonin kinase (1)

Cysteine Protease (1)

Leukotriene Receptor (1)

VEGFR (1)

Caspase (1)

PKC (1)

RANKL/RANK (1)

IAP (1)

Glucocorticoid Receptor (1)

Haspin Kinase (1)

PDGFR (1)

Somatostatin (1)

Chk (1)

Aurora Kinase (1)

Lipoxygenase (1)

IGF-1R (1)

DNA (1)

DUB (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

TGF-beta/Smad (1)

SGLT (1)

OXPHOS (1)

AChE (1)

P-gp (1)

Prostaglandin Receptor (1)

SARS-CoV (1)

LRRK2 (1)

cGAS (1)

ALK (1)

MELK (1)

Casein Kinase (1)

Influenza Virus (1)

GST (1)

Beta Amyloid (1)

PDK (1)

AMPK (1)

Adenosine deaminase (1)

FLT (1)

c-Kit (1)

S6 Kinase (1)

Microtubule Associated (1)

HIF/HIF Prolyl-Hydroxylase (1)

MLK (1)

HER (1)

NO Synthase (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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