神经信号分子库

Neuronal Signaling Compound Library

产品编号： L2600

神经元之间和神经元内部的通信对于神经系统的所有功能至关重要，无论是从发育到衰老，还是从健康到疾病。在过去十年中，我们对神经系统内分子、细胞和系统信号通路的认识取得了巨大进步，在信号通路研究方面取得了重大突破，这些神经信号通路是神经发生、成瘾、自闭症以及情绪障碍的病理生理学和治疗基础。例如：G 蛋白偶联受体（GPCR），包括5-HT 受体、组胺受体、阿片受体等，是研究较多的神经元信号传导途径，GPCR 功能障碍会引起多种神经疾病；Notch 信号途径调节神经干细胞增殖、存活、自我更新和分化，Notch 信号传导异常参与中风、阿尔茨海默病和CNS 肿瘤等疾病中发生的病理过程。因此靶向神经元信号传导，可以用来治疗多种不同CNS 疾病。

TargetMol 神经信号分子库包含2771 种与中枢神经系统信号传导有关的小分子化合物，主要用于神经系统类疾病的药物研发，可用于高通量、高内涵筛选。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

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产品描述

2771种CNS相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
靶点包括5-HT receptor、AChR、Histamine receptor、dopamine receptor、Opiod receptor等；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

5-HT Receptor (370)

AChR (301)

COX (265)

Adrenergic Receptor (246)

Dopamine Receptor (226)

Histamine Receptor (164)

GABA Receptor (158)

Calcium Channel (155)

GluR (141)

TRP/TRPV Channel (117)

AChE (107)

Apoptosis (98)

Adenosine Receptor (97)

Autophagy (94)

Endogenous Metabolite (94)

NMDAR (89)

iGluR (82)

Opioid Receptor (77)

MAO (76)

Beta Amyloid (68)

Antibacterial (48)

NF-κB (47)

P-gp (46)

Gamma-secretase (43)

Monoamine Oxidase (42)

P2X Receptor (39)

Cannabinoid Receptor (38)

Parasite (35)

Norepinephrine (35)

Potassium Channel (35)

Serotonin Transporter (33)

FAAH (33)

CaMK (33)

Sodium Channel (32)

P450 (27)

Neurokinin receptor (26)

Neuropeptide Y Receptor (23)

Reactive Oxygen Species (22)

TNF (22)

BACE (21)

NO Synthase (21)

Lipoxygenase (20)

Sigma receptor (20)

PDE (19)

GPR (19)

Antibiotic (19)

P2Y Receptor (18)

OX Receptor (18)

Antioxidant (16)

Influenza Virus (16)

NOS (15)

PPAR (15)

IL Receptor (15)

HIV Protease (14)

Beta-Secretase (13)

Prostaglandin Receptor (13)

Antifungal (12)

ERK (11)

ROS (11)

Ferroptosis (10)

Melatonin Receptor (10)

Phospholipase (10)

Imidazoline Receptor (10)

Virus Protease (9)

Akt (9)

HER (9)

Adenylyl cyclase (8)

p38 MAPK (8)

Caspase (8)

Drug Metabolite (8)

MT Receptor (8)

GlyT (8)

EGFR (8)

PGE Synthase (8)

Mitophagy (7)

BCL (7)

Interleukin (7)

DNA/RNA Synthesis (7)

STAT (7)

Melanocortin Receptor (7)

Chloride channel (6)

Carbonic Anhydrase (6)

Transferase (6)

HCV Protease (6)

Estrogen/progestogen Receptor (6)

Dehydrogenase (6)

Phosphatase (6)

PKA (6)

Wnt/beta-catenin (6)

PKC (6)

Glucocorticoid Receptor (6)

AAK1 (AP2 associated kinase 1) (6)

JAK (6)

SARS-CoV (6)

GSK-3 (5)

MRP (5)

Monoamine Transporter (5)

HSV (5)

CCR (5)

MMP (5)

IκB/IKK (5)

AMPK (5)

CGRP Receptor (5)

Tyrosinase (5)

ATPase (4)

Src (4)

PI3K (4)

Histone Demethylase (4)

Glutathione Peroxidase (4)

Serine/threonin kinase (4)

Immunology/Inflammation related (4)

Antifection (4)

TGF-beta/Smad (4)

Acyltransferase (4)

TLR (4)

Anti-infection (4)

cholecystokinin (4)

Melanin-concentrating Hormone Receptor (MCHR) (3)

Histone Methyltransferase (3)

Reductase (3)

RAAS (3)

JNK (3)

ABC (3)

PARP (3)

Neurotensin Receptor (3)

VEGFR (3)

Topoisomerase (3)

PAFR (3)

CDK (3)

Mitochondrial Metabolism (3)

Epoxide Hydrolase (3)

cAMP (3)

mTOR (3)

transporter (3)

MEK (3)

Microtubule Associated (3)

HIF/HIF Prolyl-Hydroxylase (3)

advanced glycation end products (2)

Transaminase (2)

Amino Acids and Derivatives (2)

IFNAR (2)

Arrestin (2)

Na+/Ca2+ Exchanger (2)

DYRK (2)

NADPH (2)

Lipase (2)

Progesterone Receptor (2)

HBV (2)

Estrogen Receptor/ERR (2)

Leukotriene Receptor (2)

ROCK (2)

IAP (2)

UGT (2)

Bcr-Abl (2)

Glucosidase (2)

Aurora Kinase (2)

Epigenetic Reader Domain (2)

IGF-1R (2)

DNA (2)

Androgen Receptor (2)

BCRP (2)

MAPK (2)

GluCls (2)

Nrf2 (2)

RSV (2)

GST (2)

ATM/ATR (2)

HDAC (2)

Hydroxylase (2)

Platelet aggregation (2)

NOD (2)

DNA Methyltransferase (2)

FAK (2)

p53 (2)

Proteasome (1)

CAT (1)

Monocarboxylate transporter (1)

ROR (1)

c-Met/HGFR (1)

LPL Receptor (1)

LTR (1)

Neuropeptide W (1)

gp120/CD4 (1)

GTPase (1)

N-Acetylglucosaminyltransferase (1)

Antifolate (1)

cell cycle arrest (1)

Cysteine Protease (1)

Nucleoside Antimetabolite/Analog (1)

FXR (1)

LIM Kinase (1)

Aryl Hydrocarbon Receptor (1)

Myosin (1)

Annexin A (1)

FLAP (1)

Adiponectin receptor (1)

LDL (1)

Raf (1)

Glucagon Receptor (1)

Anion Exchanger (1)

HCN Channel (1)

Fatty Acid Synthase (1)

MAGL (1)

Bombesin Receptor (1)

PAK (1)

Stearoyl-CoA Desaturase (SCD) (1)

Angiotensin-converting Enzyme (ACE) (1)

Somatostatin (1)

ACK (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Antiviral (1)

HSP (1)

STING (1)

Aminopeptidase (1)

GPCR19 (1)

Free radical scavengers (1)

Casein Kinase (1)

Reverse Transcriptase (1)

Retinoid Receptor (1)

CRISPR/Cas9 (1)

Adenosine deaminase (1)

FGFR (1)

Gap Junction Protein (1)

NMU2R (1)

FLT (1)

Syk (1)

NADPH-oxidase (1)

HMG-CoA Reductase (1)

Thrombin (1)

Protease-activated Receptor (1)

lysosomal autophagy (1)

AhR (1)

ROS Kinase (1)

NOD-like Receptor (NLR) (1)

CFTR (1)

S1P Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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