线粒体靶向库

Mitochondria-Targeted Compound Library

产品编号： L5300

线粒体是大多数真核细胞中存在的一种离散的细胞器，控制细胞代谢的基本速率，被称为“细胞的发电厂”。然而，线粒体的功能不限于提供细胞能量，线粒体是活性氧物质（ROS）的主要来源。ROS 反映了细胞氧化应激的水平，在细胞凋亡、增殖、衰老等过程发挥重要的信号传导作用。此外，线粒体是细胞钙稳态的积极参与者。线粒体Ca2+积累调节多种功能，如有氧代谢和诱导细胞死亡。线粒体DNA（mtDNA）的突变是许多线粒体代谢紊乱的原因，并且被认为通过促进细胞凋亡促进衰老。因此线粒体是药物治疗代谢性、退行性（神经退行性疾病）和过度增殖性疾病（癌症）的非常有吸引力的靶点。临床前和临床数据已经证明线粒体靶向方法具有相当大的潜力，小分子药物或生物制剂可通过各种途径作用于线粒体，包括ETC 抑制、OXPHOS 解偶联、线粒体Ca2+调节和ROS 控制等。 TargetMol 线粒体靶向库收集了950 种线粒体靶向相关的化合物，适合于线粒体靶向药物的研发和相关靶点研究。

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产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

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产品描述

TargetMol提供950种具有潜在或确定线粒体靶向活性的化合物，以促进针对线粒体的药物研究；
含有世界上唯一被认可的线粒体靶向药物Idebenone；
含有与线粒体相关的靶标抑制剂，如ATP酶、己糖激酶、Bcl-2、NADP等，也包括用于线粒体靶向药物研究的线粒体自噬调节因子ULK1的抑制剂，还包括其他热门潜在线粒体靶向化合物，包括lonidamine、paclitaxel等；
结构多样，具有药用活性，可透过细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR和HPLC检测技术保证产品高纯度；
所有化合物现货供应。

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化合物库组成

Src (98)

Apoptosis (81)

Autophagy (77)

Reactive Oxygen Species (71)

MAO (62)

Mitochondrial Metabolism (51)

AMPK (48)

Dehydrogenase (45)

BCL (39)

Monoamine Oxidase (38)

Sirtuin (34)

Mitophagy (32)

Cannabinoid Receptor (32)

PPAR (30)

ROS (26)

VEGFR (22)

Bcr-Abl (22)

NADPH (21)

Antibacterial (19)

Parasite (17)

PDGFR (16)

FGFR (15)

FLT (15)

c-Kit (14)

EGFR (13)

Endogenous Metabolite (13)

Antifungal (12)

NADPH-oxidase (10)

Antibiotic (10)

ROS Kinase (10)

Antioxidant (9)

CDK (9)

JAK (9)

Aurora Kinase (9)

COX (9)

DNA/RNA Synthesis (9)

PDK (9)

Potassium Channel (9)

P450 (8)

ATPase (7)

Ferroptosis (7)

c-Met/HGFR (7)

Calcium Channel (7)

Raf (7)

IGF-1R (7)

ALK (7)

Microtubule Associated (7)

p38 MAPK (6)

Adrenergic Receptor (6)

mTOR (6)

c-RET (6)

Histone Demethylase (5)

GSK-3 (5)

VDAC (5)

Caspase (5)

MEK (5)

Sodium Channel (5)

FAK (5)

PI3K (4)

Virus Protease (4)

Tyrosine Kinases (4)

DUB (4)

Akt (4)

AChE (4)

Trk receptor (4)

HDAC (4)

c-Fms (4)

p53 (4)

HIV Protease (3)

NOS (3)

Estrogen/progestogen Receptor (3)

Hck (3)

Cysteine Protease (3)

TRP/TRPV Channel (3)

PKC (3)

BTK (3)

Chk (3)

MMP (3)

Xanthine Oxidase (3)

OXPHOS (3)

Acyltransferase (3)

HSP (3)

Ephrin Receptor (3)

Beta Amyloid (3)

Phospholipase (3)

Syk (3)

S6 Kinase (3)

NO Synthase (3)

Mdm2 (2)

Chloride channel (2)

Monocarboxylate transporter (2)

Dopamine Receptor (2)

ADC Cytotoxin (2)

Dynamin (2)

Ligands for Target Protein for PROTAC (2)

DYRK (2)

RAAS (2)

Phosphatase (2)

PKA (2)

ROCK (2)

Glucocorticoid Receptor (2)

CSF-1R (2)

Topoisomerase (2)

IRE1 (2)

E1/E2/E3 Enzyme (2)

Hexokinase (2)

Guanylate cyclase (2)

HSV (2)

IL Receptor (2)

cAMP (2)

CaMK (2)

TGF-beta/Smad (2)

MAPK (2)

SARS-CoV (2)

LRRK2 (2)

Casein Kinase (2)

Influenza Virus (2)

IκB/IKK (2)

STAT (2)

NF-κB (2)

GABA Receptor (2)

TNF (2)

Complement System (2)

AChR (2)

HMG-CoA Reductase (2)

HIF/HIF Prolyl-Hydroxylase (2)

Imidazoline Receptor (2)

MLK (2)

CAT (1)

Carbonic Anhydrase (1)

Transferase (1)

Histone Methyltransferase (1)

Integrin (1)

YAP (1)

IFNAR (1)

Na+/Ca2+ Exchanger (1)

Arrestin (1)

BACE (1)

Histamine Receptor (1)

Tie-2 (1)

ABC (1)

MRP (1)

HBV (1)

Estrogen Receptor/ERR (1)

Wnt/beta-catenin (1)

PARP (1)

Rho (1)

Serine Protease (1)

Serotonin Transporter (1)

Serine/threonin kinase (1)

Nucleoside Antimetabolite/Analog (1)

Glucokinase (1)

ERK (1)

IAP (1)

SIK (1)

Annexin A (1)

LDL (1)

Gamma-secretase (1)

Glucagon Receptor (1)

NMDAR (1)

Fatty Acid Synthase (1)

DNA Alkylation (1)

FAAH (1)

Somatostatin (1)

Epoxide Hydrolase (1)

ACK (1)

Epigenetic Reader Domain (1)

DNA (1)

Interleukin (1)

SGLT (1)

ATP Citrate Lyase (1)

Lipid (1)

P-gp (1)

Antiviral (1)

STING (1)

TLR (1)

Free radical scavengers (1)

CPT (1)

Nrf2 (1)

Reverse Transcriptase (1)

GPR (1)

5-HT Receptor (1)

Hydroxylase (1)

SGK (1)

Discoidin Domain Receptor (DDR) (1)

Gap Junction Protein (1)

BMI-1 (1)

Ras (1)

TAM Receptor (1)

Tyrosinase (1)

Thrombin (1)

p97 (1)

AhR (1)

NOD-like Receptor (NLR) (1)

CFTR (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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