JAK-STAT 化合物库

JAK-STAT Compound Library

产品编号： L3700

细胞信号传导通路是细胞内蛋白质之间相互作用的级联反应，将信号逐级传递并放大。JAK-STAT 信号传导途径将细胞外的化学信号传递到细胞核，通过调节转录过程调控相关基因表达。该途径有三个关键部分：受体（结合细胞外化学信号）、JAKs（Janus 激酶）和 STATs（信号转导因子和转录蛋白激活因子）。JAK-STAT 信号传导途径参与调控免疫、细胞分裂、细胞死亡和肿瘤形成等多种生物过程，因此该信号传导途径的异常可能导致多种疾病，如皮肤病，癌症和免疫系统的疾病等。研究表明 JAKs 激酶有四种亚型(JAK1、JAK2、JAK3 和 TYK2)，STAT 有7种亚型(STAT1、STAT2、STAT3、STAT4、STAT5A、STAT5B 和 STAT6)。

TargetMol JAK-STAT 化合物库是 415 个 JAK/STAT 靶点相关的小分子化合物的独特集合，用于 JAK/STAT 靶点相关的研究以及药物的筛选，可用于高通量、高内涵筛选。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

415 个JAK/STAT靶点相关的小分子化合物的独特集合，用于高通量、高内涵筛选；
产品经过临床验证和临床实验，具有生物安全保障和一定的生物活性；
是研究JAK/STAT靶点的有效工具；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR和HPLC检测技术保证产品高纯度和高质量；
所有化合物现货供应。

化合物库定制

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化合物库咨询

化合物库组成

EGFR (185)

JAK (127)

STAT (94)

Apoptosis (75)

HER (51)

Autophagy (32)

Tyrosine Kinases (24)

Pim (23)

VEGFR (17)

NF-κB (17)

FLT (17)

Src (15)

CDK (14)

Potassium Channel (14)

FGFR (12)

BTK (10)

PDGFR (10)

ERK (7)

Bcr-Abl (7)

Antibacterial (7)

Endogenous Metabolite (7)

p38 MAPK (6)

Parasite (6)

IL Receptor (6)

COX (6)

IGF-1R (5)

Akt (5)

5-HT Receptor (5)

c-RET (5)

TNF (5)

HIV Protease (4)

c-Met/HGFR (4)

Aurora Kinase (4)

Interleukin (4)

IκB/IKK (4)

P450 (4)

c-Kit (4)

Sodium Channel (4)

Antibiotic (4)

Histone Methyltransferase (3)

Ferroptosis (3)

JNK (3)

PKA (3)

Caspase (3)

Calcium Channel (3)

PKC (3)

Drug Metabolite (3)

Somatostatin (3)

DNA/RNA Synthesis (3)

TLR (3)

ALK (3)

Beta Amyloid (3)

AMPK (3)

MEK (3)

AChR (3)

HCV Protease (2)

PI3K (2)

Antioxidant (2)

DYRK (2)

Histamine Receptor (2)

Phosphatase (2)

Virus Protease (2)

Estrogen Receptor/ERR (2)

Wnt/beta-catenin (2)

Topoisomerase (2)

RIP kinase (2)

Raf (2)

BCL (2)

Reactive Oxygen Species (2)

mTOR (2)

P-gp (2)

HSP (2)

Histone Acetyltransferase (2)

Casein Kinase (2)

Influenza Virus (2)

HDAC (2)

DAPK (2)

Syk (2)

FAK (2)

NO Synthase (2)

Melanin-concentrating Hormone Receptor (MCHR) (1)

NOS (1)

Dopamine Receptor (1)

Integrin (1)

Estrogen/progestogen Receptor (1)

IFNAR (1)

Na+/Ca2+ Exchanger (1)

GTPase (1)

Mitophagy (1)

GSK-3 (1)

OCT (1)

HBV (1)

Serine/threonin kinase (1)

Cysteine Protease (1)

Nucleoside Antimetabolite/Analog (1)

PYK2 (1)

TRP/TRPV Channel (1)

ROCK (1)

Adrenergic Receptor (1)

CSF-1R (1)

UGT (1)

PDE (1)

NMDAR (1)

Antifection (1)

ROS (1)

FAAH (1)

CCR (1)

PTEN (1)

MMP (1)

Chk (1)

ACK (1)

GluR (1)

cAMP (1)

Thrombopoietin Receptor (1)

Epigenetic Reader Domain (1)

CaMK (1)

DUB (1)

TGF-beta/Smad (1)

MNK (1)

Survivin (1)

Antiviral (1)

Trk receptor (1)

Sirtuin (1)

Ephrin Receptor (1)

Nrf2 (1)

hCE (1)

RSV (1)

MELK (1)

Hippo pathway (1)

ATM/ATR (1)

Reverse Transcriptase (1)

c-Fms (1)

GPR (1)

PLK (1)

HIF (1)

SGK (1)

Anti-infection (1)

NADPH-oxidase (1)

IRAK (1)

Ras (1)

S6 Kinase (1)

cholecystokinin (1)

Sigma receptor (1)

Tyrosinase (1)

HIF/HIF Prolyl-Hydroxylase (1)

ROS Kinase (1)

MLK (1)

PD-1/PD-L1 (1)

Monoamine Oxidase (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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