离子通道库 | TargetMol

Ion Channel Targeted Library

产品编号： L2300

离子跨膜通道的调节是治疗多种疾病的基础，离子通道是开发新的高效药物治疗的重要靶点，随着人类基因组计划的完成和转录机制研究的深入，离子通道分布的组织特异性逐渐得以阐明，这将使离子通道成为一类有选择性的组织特异性药物靶点。离子通道对于细胞间通讯至关重要，并调节多种重要的生理过程，这些过程功能障碍，可导致广泛的疾病和病理状况，如糖尿病、神经性疼痛、心血管疾病、大脑和外周血管疾病、哮喘、神经退行性疾病。

为满足客户离子通道相关研究的化合物需求，我们根据文献报道和其他公开资料精心整理 1147 种与离子通道相关的生物活性小分子化合物，适用于离子通道相关的疾病和药物研究。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

1147种与离子通道相关的生物活性小分子化合物的特有集合，用于离子通道相关的疾病和药物研究，可用于高通量筛选和高内涵筛选；
靶点含K+通道、Ca2+通道、Na+通道、质子泵等；
通过前期临床研究和临床实验，生物活性和安全性已经得到验证；
其中一些活性化合物已得到FDA批准上市；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR和HPLC检测技术保证产品高纯度和高质量；
所有化合物现货供应。

化合物库定制

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化合物库组成

Calcium Channel (195)

Potassium Channel (193)

Sodium Channel (156)

GABA Receptor (124)

TRP/TRPV Channel (112)

AChR (103)

iGluR (78)

Autophagy (45)

P2X Receptor (38)

NMDAR (37)

Chloride channel (22)

5-HT Receptor (22)

GluR (19)

Adrenergic Receptor (18)

Apoptosis (18)

Parasite (16)

Dopamine Receptor (12)

Histamine Receptor (10)

HER (10)

P450 (9)

COX (7)

Antibacterial (7)

Endogenous Metabolite (7)

PPAR (6)

Reactive Oxygen Species (6)

Carbonic Anhydrase (5)

VDAC (5)

HCN Channel (5)

EGFR (5)

P-gp (5)

NF-κB (5)

ATPase (4)

HIV Protease (4)

Na+/Ca2+ Exchanger (4)

ABC (4)

PKA (4)

PKC (4)

ERK (4)

Drug Metabolite (4)

CaMK (4)

Cannabinoid Receptor (4)

Ferroptosis (3)

NADPH (3)

Virus Protease (3)

MRP (3)

Serine/threonin kinase (3)

Topoisomerase (3)

PDE (3)

Norepinephrine (3)

SARS-CoV (3)

GPR (3)

Phospholipase (3)

NOS (2)

Transaminase (2)

HCV Protease (2)

Antifungal (2)

RAAS (2)

Mitophagy (2)

Wnt/beta-catenin (2)

ROCK (2)

LDL (2)

Mitochondrial Metabolism (2)

Lipoxygenase (2)

DNA/RNA Synthesis (2)

Beta-Secretase (2)

AChE (2)

Acyltransferase (2)

STAT (2)

HDAC (2)

AMPK (2)

MEK (2)

TNF (2)

DNA Methyltransferase (2)

HMG-CoA Reductase (2)

Thrombin (2)

Antibiotic (2)

AhR (2)

Proteasome (1)

Proton pump (1)

Monocarboxylate transporter (1)

Piezo Channel (1)

Src (1)

Integrin (1)

Estrogen/progestogen Receptor (1)

Dehydrogenase (1)

Antioxidant (1)

LPL Receptor (1)

LTR (1)

Arrestin (1)

Phosphatase (1)

GSK-3 (1)

N-Acetylglucosaminyltransferase (1)

Estrogen Receptor/ERR (1)

HBV (1)

Serotonin Transporter (1)

VEGFR (1)

Caspase (1)

MAO (1)

Glucocorticoid Receptor (1)

CSF-1R (1)

UGT (1)

Gamma-secretase (1)

CDK (1)

MT Receptor (1)

GlyT (1)

Na-K-Cl cotransporter (1)

Antifection (1)

Monoamine Transporter (1)

Anion Exchanger (1)

Opioid Receptor (1)

PAK (1)

HSV (1)

IL Receptor (1)

IGF-1R (1)

DNA (1)

Androgen Receptor (1)

mTOR (1)

Interleukin (1)

BCRP (1)

Trk receptor (1)

GluCls (1)

Influenza Virus (1)

IκB/IKK (1)

GST (1)

Gap Junction Protein (1)

Sigma receptor (1)

Protease-activated Receptor (1)

CFTR (1)

S1P Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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