抑制剂库 | TargetMol

Inhibitor Library

产品编号： L2000

细胞信号控制细胞基本活动，调控细胞行为。细胞感知并准确响应微环境的变化是发育、组织修复和免疫的基础，也是正常组织稳态的基础。细胞信号间相互作用异常或细胞信息处理错误是导致癌症、自身免疫和糖尿病等疾病的原因。深入了解细胞信号传导，疾病可得到更有效的治疗。

TargetMol 抑制剂库是由9730 个靶向小分子化合物组成的集合，每一个化合物都有明确的抑制靶点，靶点所处的信号通路也因此被阻断，TargetMol 抑制剂库是研究信号通路及相关疾病的有力工具，可用于高通量筛选和高内涵筛选。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

9730个小分子抑制剂的独特集合，主要用于细胞信号研究、新药筛选、高通量筛选和高内涵筛选；
通过临床前研究和临床实验，生物活性和安全性已经得到验证；部分抑制剂已经被FDA批准上市；
作用于MAPK、PI3K、JAK、HDAC、VEGFR、CDK等靶点，阻断相关信号通路；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Apoptosis (850)

Autophagy (580)

Antibacterial (352)

5-HT Receptor (295)

CDK (225)

COX (201)

Antibiotic (190)

AChR (189)

PI3K (186)

EGFR (185)

Endogenous Metabolite (179)

HIV Protease (177)

DNA/RNA Synthesis (176)

Adrenergic Receptor (173)

Dopamine Receptor (170)

NF-κB (163)

PDE (162)

Calcium Channel (161)

VEGFR (160)

Epigenetic Reader Domain (156)

Histamine Receptor (152)

Dehydrogenase (151)

P450 (136)

Histone Methyltransferase (134)

Potassium Channel (133)

Sodium Channel (129)

HDAC (128)

JAK (126)

Parasite (125)

Phosphatase (114)

Antifungal (106)

mTOR (105)

FLT (101)

Src (100)

Microtubule Associated (96)

Topoisomerase (94)

TRP/TRPV Channel (93)

SARS-CoV (91)

PDGFR (90)

AChE (88)

PARP (84)

FGFR (83)

PKC (82)

Wnt/beta-catenin (80)

Raf (80)

Akt (80)

HCV Protease (77)

p38 MAPK (77)

Influenza Virus (77)

STAT (77)

RAAS (76)

ERK (76)

c-Kit (76)

GSK-3 (75)

MAO (74)

Prostaglandin Receptor (74)

GABA Receptor (72)

Lipoxygenase (68)

c-Met/HGFR (67)

Bcr-Abl (67)

ALK (65)

TNF (65)

MMP (64)

NMDAR (63)

Proteasome (62)

Adenosine Receptor (60)

BCL (58)

Reactive Oxygen Species (58)

GluR (58)

Phospholipase (58)

Ferroptosis (57)

DUB (57)

HSP (57)

Aurora Kinase (56)

BTK (55)

Virus Protease (54)

Kras (54)

Histone Demethylase (53)

Tyrosinase (52)

TGF-beta/Smad (51)

GPR (50)

Tyrosine Kinases (49)

CCR (49)

Ras (49)

Transferase (48)

ROCK (48)

iGluR (48)

MAPK (48)

HER (48)

ATPase (47)

IL Receptor (47)

E1/E2/E3 Enzyme (46)

MEK (46)

Integrin (45)

Casein Kinase (45)

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NO Synthase (45)

Caspase (44)

Monoamine Oxidase (44)

JNK (43)

PKA (43)

PPAR (43)

Antiviral (43)

Serine/threonin kinase (42)

Serotonin Transporter (41)

Carbonic Anhydrase (40)

IκB/IKK (40)

Reverse Transcriptase (40)

DNA-PK (39)

Antioxidant (39)

Mitophagy (39)

Cysteine Protease (39)

HBV (38)

Mitochondrial Metabolism (38)

HSV (38)

Androgen Receptor (38)

Sirtuin (38)

AMPK (38)

CXCR (37)

c-RET (37)

Reductase (36)

NOS (35)

Norepinephrine (35)

HIF (35)

TAM Receptor (35)

ADC Cytotoxin (34)

Estrogen/progestogen Receptor (34)

Serine Protease (34)

RIP kinase (34)

P2X Receptor (34)

ROS (34)

IGF-1R (34)

P-gp (34)

Estrogen Receptor/ERR (33)

Nucleoside Antimetabolite/Analog (33)

CaMK (33)

Histone Acetyltransferase (33)

Gamma-secretase (32)

Glucosidase (32)

Drug Metabolite (31)

TLR (31)

HIF/HIF Prolyl-Hydroxylase (31)

Proton pump (30)

Interleukin (30)

Trk receptor (30)

FAK (30)

Hedgehog/Smoothened (29)

FAAH (29)

Acyltransferase (29)

c-Fms (29)

PLK (29)

S6 Kinase (29)

Cannabinoid Receptor (28)

ATM/ATR (27)

Neurokinin receptor (27)

Syk (27)

p53 (27)

Glucocorticoid Receptor (26)

Opioid Receptor (26)

DPP-4 (26)

NOD (26)

HMG-CoA Reductase (26)

Pim (25)

Endothelin Receptor (25)

Chk (25)

Fatty Acid Synthase (24)

Kinesin (24)

Chloride channel (23)

DYRK (22)

Antifection (22)

Indoleamine 2,3-Dioxygenase (IDO) (22)

SGLT (22)

Thrombin (22)

LTR (21)

NADPH (21)

Factor Xa (21)

Rho (21)

Leukotriene Receptor (21)

LRRK2 (21)

transporter (21)

Anti-infection (21)

DNA Methyltransferase (21)

IRAK (21)

Mdm2 (20)

BACE (20)

Lipase (20)

Xanthine Oxidase (20)

PDK (20)

PD-1/PD-L1 (20)

LPL Receptor (19)

Immunology/Inflammation related (19)

S1P Receptor (19)

P2Y Receptor (18)

PERK (18)

Glutathione Peroxidase (18)

Smo (18)

Nrf2 (18)

Hydroxylase (18)

Sigma receptor (18)

DHFR (17)

MRP (17)

PAK (17)

Epoxide Hydrolase (17)

cAMP (17)

Retinoid Receptor (17)

Complement System (17)

Glucokinase (16)

OX Receptor (16)

LPA Receptor (16)

PI4K (16)

cholecystokinin (16)

ROS Kinase (16)

YAP (15)

c-Myc (15)

IRE1 (15)

Neuropeptide Y Receptor (15)

GTPase (14)

Aryl Hydrocarbon Receptor (14)

CSF-1R (14)

IAP (14)

Myosin (14)

Ephrin Receptor (14)

ribosome (14)

Aromatase (14)

Antifolate (13)

DNA (13)

PGE Synthase (13)

Aminopeptidase (13)

Protease-activated Receptor (13)

AhR (13)

Telomerase (12)

Beta-Secretase (12)

RSV (12)

Discoidin Domain Receptor (DDR) (12)

Monocarboxylate transporter (11)

CETP (11)

ABC (11)

IDO (11)

DNA gyrase (11)

Monoamine Transporter (11)

Isocitrate Dehydrogenase (IDH) (11)

Stearoyl-CoA Desaturase (SCD) (11)

Vasopressin Receptor (11)

Acetyl-CoA Carboxylase (11)

Platelet aggregation (11)

NOD-like Receptor (NLR) (11)

Glutaminase (10)

GRK (10)

Bradykinin Receptor (10)

Lipid (10)

PAI-1 (10)

Melanocortin Receptor (10)

NADPH-oxidase (10)

CFTR (10)

MLK (10)

GNRH Receptor (9)

NAMPT (9)

Phosphorylase (9)

ATP Citrate Lyase (9)

BCRP (9)

MNK (9)

STING (9)

Neprilysin (9)

SGK (9)

Dynamin (8)

Ligands for Target Protein for PROTAC (8)

Tie-2 (8)

SIK (8)

PAFR (8)

LDL (8)

Glucagon Receptor (8)

GlyT (8)

PAD (8)

OAT (8)

Porcupine (8)

ASK (8)

GST (8)

Carboxypeptidase (8)

Adenylyl cyclase (7)

CRM1 (7)

Na+/Ca2+ Exchanger (7)

LIM Kinase (7)

Neurotensin Receptor (7)

PYK2 (7)

UGT (7)

Guanylate cyclase (7)

APC (7)

MAGL (7)

DNA Alkylation (7)

Angiotensin-converting Enzyme (ACE) (7)

CRFR (7)

GPX (7)

p97 (7)

Thyroid hormone receptor(THR) (6)

ROR (6)

DNA Alkylator/Crosslinker (6)

Progesterone Receptor (6)

FLAP (6)

MT Receptor (6)

AAK1 (AP2 associated kinase 1) (6)

Transketolase (6)

Wee1 (6)

cGAS (6)

MELK (6)

Methionine Adenosyltransferase (MAT) (6)

Protease (6)

Ligand for E3 Ligase (6)

Gap Junction Protein (6)

Melanin-concentrating Hormone Receptor (MCHR) (5)

PROTACs (5)

MALT (5)

DprE1 (5)

MyD88 (5)

Amino Acids and Derivatives (5)

Amylase (5)

MTH1 (5)

Bombesin Receptor (5)

ACK (5)

Survivin (5)

CD73 (5)

Decarboxylase (5)

Hippo pathway (5)

CRISPR/Cas9 (5)

Aquaporin (5)

GHSR (5)

Adenosine deaminase (5)

CGRP Receptor (5)

DAPK (5)

BMI-1 (5)

advanced glycation end products (4)

NPC1L1 (4)

CD38 (4)

NEDD8 (4)

TOPK (4)

Melatonin Receptor (4)

Galectin (4)

CaSR (4)

VDAC (4)

Hexokinase (4)

HCN Channel (4)

PTEN (4)

KSP (4)

Pyroptosis (4)

Drug-Linker Conjugates for ADC (4)

Imidazoline Receptor (4)

PKM (4)

Apelin receptor (3)

CAT (3)

Transaminase (3)

Arginase (3)

IFNAR (3)

Arrestin (3)

Necroptosis (3)

Hck (3)

Liver X Receptor (3)

Haspin Kinase (3)

Mucin (3)

OXPHOS (3)

PSMA (3)

HuR (3)

Oxytocin Receptor (3)

Glyoxalase (3)

GSNOR (2)

NUDIX hydrolase (2)

EBI2/GPR183 (2)

Sodium-dependent phosphate transporter (2)

gp120/CD4 (2)

Kisspeptin (2)

FXR (2)

Vitamin (2)

FOXO1 (2)

Prolyl Endopeptidase (PREP) (2)

Na-K-Cl cotransporter (2)

Molecular Glues (2)

Integrase (2)

Somatostatin (2)

AIM2 (2)

hCE (2)

TSH Receptor (2)

KLF (2)

Taste receptor (1)

stilbene oxidase (1)

Piezo Channel (1)

Procollagen C Proteinase (1)

Neuropeptide W (1)

aconitase (1)

RAR/RXR (1)

Cell wall (1)

LHRH (1)

VDA (1)

OCT (1)

N-Acetylglucosaminyltransferase (1)

Stemness kinase (1)

RANKL/RANK (1)

Annexin A (1)

Adiponectin receptor (1)

Fas/FasL (1)

FABP (1)

PACAP (1)

Anion Exchanger (1)

Thioredoxin (1)

PGC-1α (1)

Glutathione reductase (1)

MRGPR (1)

GPCR19 (1)

CPT (1)

GluCls (1)

Fer/FerT kinase (1)

lysosomal autophagy (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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