HIF-1化合物库

HIF-1 Signaling Pathway Compound Library

产品编号： L8500

“氧感知通路”于2019年获诺贝尔生理学或医学奖，作为一种关键的调控蛋白，低氧诱导因子-1(hypoxia inducible factor-1，HIF-1)受到广泛关注，其普遍存在于人和哺乳动物细胞内，有相当广泛的靶基因谱，其中包括与缺氧适应、炎症发展及肿瘤生长等相关的近100种靶基因。

低氧诱导因子（HIF-1）在人类的代谢调节中，属于一个核心角色。在细胞中，HIF 信号级联反应会受到缺氧状态的影响。在缺氧状态下，通常会让细胞持续的细胞分化。然而，缺氧状态促进了血管新生，对于胚胎中的血管系统与癌症肿瘤来说非常重要。伤口处的缺氧状态，也促进了角质细胞的移动与上皮组织的修护。在普遍情况下，HIF 也是发育的重要关键。在哺乳动物中，若缺少了HIF-1的基因，将导致胎儿死亡。HIF-1已经被证实，对于软骨细胞的存亡有重大的影响，它能使软骨细胞适应在骨骼间生长板的缺氧环境。

揭示生物氧气感知通路，不仅在基础科学上有其价值，还有望带来创新的疗法。比如倘若能通过调控HIF-1通路，促进红细胞的生成，就有望治疗贫血。而干扰HIF-1的降解，则能促进血管生成，治疗循环不良。另一方面，由于肿瘤的生成离不开新生血管，如果能降解HIF-1α或相关蛋白（如HIF-2α），就有望对抗恶性肿瘤。

为满足研究“氧感知通路”相关客户的需求，TargetMol 收集了2080 个HIF-1相关的小分子，涉及PI3K-AKT, MAPK, Ubiquitination 等信号通路及HIF, HIF Prolyl-Hydroxylase, E1/E2/E3 Enzyme, PI3K, MAPK, Proteasome 等靶点，可用于氧感知通路的相关药物开发和药理研究。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

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陶术生物化合物库目录(2.8MB)

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产品描述

2080个HIF-1相关小分子的独特集合，可用于缺血性疾病、癌症等相关领域的药物开发和药理研究；
涉及PI3K-AKT、MAPK、Ubiquitination等信号通路及HIF, HIF Prolyl-Hydroxylase, E1/E2/E3 Enzyme, PI3K, MAPK, Proteasome等靶点；
部分化合物已进入临床或经FDA批准上市；
详细的说明书，化合物结构、靶点信息、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Apoptosis (351)

NF-κB (269)

Autophagy (261)

PI3K (211)

COX (162)

HDAC (131)

TNF (121)

mTOR (116)

Akt (113)

Src (102)

ERK (88)

AMPK (88)

GSK-3 (86)

p38 MAPK (82)

ROS (69)

Antibacterial (68)

TLR (68)

TGF-beta/Smad (65)

MAPK (60)

Raf (59)

CDK (59)

IL Receptor (58)

HIF/HIF Prolyl-Hydroxylase (57)

Endogenous Metabolite (56)

Ras (54)

Proteasome (53)

Kras (50)

p53 (48)

HIF (46)

JNK (45)

MEK (43)

Reactive Oxygen Species (41)

E1/E2/E3 Enzyme (39)

DNA-PK (38)

VEGFR (36)

HSP (35)

S6 Kinase (32)

HIV Protease (30)

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DUB (30)

ATM/ATR (30)

Caspase (29)

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PKC (19)

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NOS (18)

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Aurora Kinase (18)

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PKA (17)

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MMP (16)

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transporter (4)

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HER (3)

PROTACs (2)

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MyD88 (2)

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IFNAR (2)

Histone Demethylase (2)

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MRP (2)

Estrogen Receptor/ERR (2)

Pim (2)

PYK2 (2)

CSF-1R (2)

RIP kinase (2)

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NMDAR (2)

Fatty Acid Synthase (2)

ACK (2)

DNA (2)

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ATP Citrate Lyase (2)

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LRRK2 (2)

Aminopeptidase (2)

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GPR (2)

5-HT Receptor (2)

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BMI-1 (2)

AhR (2)

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S1P Receptor (2)

NPC1L1 (1)

Dopamine Receptor (1)

Histone Methyltransferase (1)

Dynamin (1)

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Ligands for Target Protein for PROTAC (1)

YAP (1)

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PERK (1)

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gp120/CD4 (1)

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GST (1)

GPX (1)

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CRISPR/Cas9 (1)

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Discoidin Domain Receptor (DDR) (1)

HMG-CoA Reductase (1)

Sigma receptor (1)

cholecystokinin (1)

Protease-activated Receptor (1)

CFTR (1)

Kinesin (1)

PKM (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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