清热解毒中药单体库

Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library

产品编号： L6760

清热解毒是中医学的重要理论和治疗原则之一，《黄帝内经》记载的“风寒暑湿燥火，谓之六淫”，“凡病温者，先夏至日者为病温，后夏至日者为病暑”，以及“热者寒之”等论述，奠定了清热解毒治则的理论基础。常见的清热解毒中药有金银花、连翘、蒲公英、鱼腥草、板蓝根、大青叶、黄芩、黄连等，这类中药药性多为寒凉，故能清除体内实热或虚热，解毒消肿。

历史上，清热解毒药被广泛应用于瘟疫、疮疡、咽喉肿痛等热性疾病的治疗。例如，板蓝根在明清时期就被用来预防和治疗流行性感冒。进入现代社会，随着对中药成分及其作用机制的深入研究，清热解毒类药物的应用范围进一步扩大。现代研究表明，这类药物不仅能够改善炎症反应、抗病毒和抗菌，还能调节免疫功能、保护器官功能，并改善代谢紊乱。

为了更好地研究清热解毒中药发挥药理作用的主要成分及其作用机制，TargetMol建立了清热解毒中药单体库，收集了1323个来源于常见清热解毒中药的单体化合物，可作为药物开发和药理研究的有效工具，也可为深入理解中药多成分、多靶点特性提供数据支持。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

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陶术生物化合物库目录(2.8MB)

库化合物信息

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产品描述

1323个来源于清热解毒中药材的单体化合物集合，可以用于高通量和高内涵筛选；
来源包括金银花、菊花、连翘、黄连、大青叶等108种清热解毒中药材；
结构多样，包括黄酮类、萜类、酚类和生物碱等超15种结构类型，且提供分类信息；
提供通路靶点受体信息，药效显著，可渗透细胞；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Endogenous Metabolite (257)

Apoptosis (163)

Antibacterial (111)

Autophagy (102)

NF-κB (88)

Antioxidant (80)

Reactive Oxygen Species (53)

COX (45)

Antifungal (44)

Influenza Virus (38)

TNF (33)

Parasite (32)

P450 (30)

Cholinesterase (ChE) (27)

NO Synthase (26)

HIV Protease (25)

Ferroptosis (22)

IL Receptor (22)

Virus Protease (21)

AChR (21)

p38 MAPK (20)

PPAR (19)

Akt (19)

Calcium Channel (18)

ERK (18)

ROS (18)

GABA Receptor (18)

Tyrosinase (18)

Antibiotic (18)

MMP (17)

Caspase (16)

DNA/RNA Synthesis (16)

Anti-infection (16)

AMPK (15)

5-HT Receptor (14)

PI3K (13)

MAO (13)

Immunology/Inflammation related (12)

Glucosidase (12)

Nrf2 (12)

STAT (12)

Estrogen Receptor/ERR (11)

TRP/TRPV Channel (11)

Prostaglandin Receptor (11)

Phosphatase (10)

Mitophagy (10)

PKC (10)

BCL (10)

Lipoxygenase (10)

Dehydrogenase (9)

JNK (9)

PARP (9)

Topoisomerase (9)

HSV (9)

Interleukin (9)

Antiviral (9)

ATPase (8)

BACE (8)

Wnt/beta-catenin (8)

Adrenergic Receptor (8)

SARS-CoV (8)

NOS (7)

Reductase (7)

Mitochondrial Metabolism (7)

TGF-beta/Smad (7)

Beta Amyloid (7)

HIF/HIF Prolyl-Hydroxylase (7)

Estrogen/progestogen Receptor (6)

RAAS (6)

HBV (6)

PDE (6)

CDK (6)

Antifection (6)

JAK (6)

CCR (6)

mTOR (6)

Indoleamine 2,3-Dioxygenase (IDO) (6)

TLR (6)

Carbonic Anhydrase (5)

Dopamine Receptor (5)

iGluR (5)

MAPK (5)

Reverse Transcriptase (5)

Potassium Channel (5)

Monoamine Oxidase (5)

Chloride channel (4)

Adenosine Receptor (4)

UGT (4)

Gamma-secretase (4)

Opioid Receptor (4)

Fatty Acid Synthase (4)

Androgen Receptor (4)

EGFR (4)

P-gp (4)

Sirtuin (4)

transporter (4)

Phospholipase (4)

HIF (4)

MEK (4)

Platelet aggregation (4)

NOD (4)

HMG-CoA Reductase (4)

Proton pump (3)

ROR (3)

HCV Protease (3)

c-Myc (3)

Serine Protease (3)

Amylase (3)

PAFR (3)

Drug Metabolite (3)

CXCR (3)

Xanthine Oxidase (3)

CaMK (3)

Beta-Secretase (3)

Acyltransferase (3)

HSP (3)

Free radical scavengers (3)

IκB/IKK (3)

HDAC (3)

Aromatase (3)

FGFR (3)

Cannabinoid Receptor (3)

Microtubule Associated (3)

p53 (3)

Proteasome (2)

Integrin (2)

Amino Acids and Derivatives (2)

Arginase (2)

NADPH (2)

Histamine Receptor (2)

Glutathione Peroxidase (2)

Melatonin Receptor (2)

PKA (2)

Cysteine Protease (2)

Nucleoside Antimetabolite/Analog (2)

VEGFR (2)

Aryl Hydrocarbon Receptor (2)

Adiponectin Receptor (2)

LDL (2)

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PTEN (2)

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Aurora Kinase (2)

IGF-1R (2)

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Lipid (2)

PGE Synthase (2)

Aminopeptidase (2)

Pyroptosis (2)

RSV (2)

Casein Kinase (2)

GST (2)

Syk (2)

Sodium Channel (2)

S6 Kinase (2)

AhR (2)

Imidazoline Receptor (2)

PKM (2)

Advanced Glycation End Products (1)

Transferase (1)

Transaminase (1)

Monocarboxylate transporter (1)

stilbene oxidase (1)

DHFR (1)

CYP19A1 (1)

Src (1)

Dynamin (1)

MyD88 (1)

LTR (1)

DYRK (1)

Lipase (1)

GSK-3 (1)

OCT (1)

CaSR (1)

MRP (1)

Tyrosine Kinases (1)

Pim (1)

Serine/threonin kinase (1)

Liver X Receptor (1)

Glucokinase (1)

RANKL/RANK (1)

IAP (1)

E1/E2/E3 Enzyme (1)

Bcr-Abl (1)

Raf (1)

MT Receptor (1)

Phosphorylase (1)

ABC Transporter (1)

DNA gyrase (1)

PDGFR (1)

Hedgehog/Smoothened (1)

FAAH (1)

Stearoyl-CoA Desaturase (SCD) (1)

Angiotensin-converting Enzyme (ACE) (1)

GluR (1)

Norepinephrine (1)

DNA (1)

ATP Citrate Lyase (1)

Survivin (1)

OAT (1)

Trk receptor (1)

Histone Acetyltransferase (1)

GPR (1)

PDK (1)

Ras (1)

Thrombin (1)

FAK (1)

ROS Kinase (1)

CFTR (1)

PD-1/PD-L1 (1)

HER (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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