GPCR靶点分子库

GPCR Compound Library

产品编号： L1500

G 蛋白偶联受体（GPCR）的超家族是对真核细胞信号传导至关重要的多种跨膜蛋白。 GPCR 启动细胞对各种胞外介质的反应，参与几乎所有常见的人类疾病。近40％的上市药物通过调节 GPCR 功能起作用，70%的在研治疗新方法靶向 GPCR，此外，数百个“孤儿”GPCR（尚未鉴定出天然配体）是许多药物发现计划中研究的焦点。GPCR 靶向候选药物必须是对靶蛋白具有高亲和、特异性和合理的膜渗透性。TargetMol GPCR 靶向化合物库是由 2273 种与 G 蛋白及其耦联受体相关的生物活性小分子化合物的特有集合。用于GPCR 靶向的药物研发，GPCR 相关科学研究和药物筛选，可用于高通量、高内涵筛选。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

2273种与G蛋白及其耦联受体相关的生物活性小分子化合物，所有小分子都具有良好的生物和药理活性，部分是FDA批准的上市药物；
是筛选GPCR 靶向药物的强大工具，也可用于制药公司和生物技术公司在各项研究和药物开发项目中GPCR的筛选；
据估计大约200个孤儿GPCR功能是未知的，因此，使用我们的GPCR小分子化合物库来筛选功能未知的GPCR可能会产生潜在的新型GPCR候选药；
GPCR化合物库含有与受体相关的小分子，包括5-HT 受体、多巴胺受体、阿片受体、肾上腺素受体、大麻素受体、mGluR和 ETA-受体等；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

化合物库定制

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化合物库组成

5-HT Receptor (428)

Adrenergic Receptor (290)

Dopamine Receptor (254)

Histamine Receptor (195)

GPR (120)

Prostaglandin Receptor (108)

Adenosine Receptor (103)

Opioid Receptor (102)

Cannabinoid Receptor (71)

Apoptosis (68)

Autophagy (65)

Endogenous Metabolite (62)

AChR (54)

Ras (54)

Kras (52)

CCR (48)

Neurokinin receptor (45)

CXCR (44)

S1P Receptor (42)

Hedgehog/Smoothened (38)

LPL Receptor (35)

Sigma receptor (34)

Norepinephrine (33)

Serotonin Transporter (30)

Neuropeptide Y Receptor (28)

Endothelin Receptor (28)

Antibacterial (26)

Protease-activated Receptor (26)

Glucagon Receptor (25)

cAMP (25)

Calcium Channel (23)

P2Y Receptor (22)

Leukotriene Receptor (22)

Guanylate cyclase (22)

SGLT (22)

PDE (21)

LPA Receptor (21)

Potassium Channel (21)

Bradykinin Receptor (20)

Melanocortin Receptor (20)

cholecystokinin (20)

OX Receptor (19)

GNRH Receptor (18)

Vasopressin Receptor (18)

GTPase (17)

P450 (17)

GHSR (15)

Rho (14)

Neurotensin Receptor (14)

Somatostatin (14)

Smo (13)

GPCR19 (13)

NO Synthase (13)

HIV Protease (12)

CaSR (12)

Parasite (12)

TRP/TRPV Channel (11)

GRK (11)

COX (11)

Influenza Virus (11)

Melatonin Receptor (10)

PAFR (10)

Bombesin Receptor (10)

NF-κB (10)

Sodium Channel (10)

Antibiotic (10)

Arrestin (9)

Raf (9)

Antifungal (8)

PPAR (8)

Lipoxygenase (8)

Apelin receptor (7)

Annexin A (7)

Reactive Oxygen Species (7)

CaMK (7)

AChE (7)

CRFR (7)

Oxytocin Receptor (7)

HER (7)

Melanin-concentrating Hormone Receptor (MCHR) (6)

NOS (6)

PI3K (6)

LTR (6)

PKA (6)

Glucocorticoid Receptor (6)

CDK (6)

MT Receptor (6)

NMDAR (6)

IL Receptor (6)

P-gp (6)

TSH Receptor (6)

GABA Receptor (6)

CGRP Receptor (6)

TNF (6)

Monoamine Oxidase (6)

Transferase (5)

HCV Protease (5)

Mitophagy (5)

ERK (5)

Drug Metabolite (5)

Histone Methyltransferase (4)

Virus Protease (4)

Kisspeptin (4)

ABC (4)

PKC (4)

MAO (4)

Immunology/Inflammation related (4)

P2X Receptor (4)

ROS (4)

GluR (4)

EGFR (4)

Akt (4)

DNA/RNA Synthesis (4)

Acyltransferase (4)

HSP (4)

HDAC (4)

Phospholipase (4)

ATPase (3)

p38 MAPK (3)

Ferroptosis (3)

RAAS (3)

Glutathione Peroxidase (3)

Phosphatase (3)

FXR (3)

VEGFR (3)

Caspase (3)

ROCK (3)

iGluR (3)

Adiponectin receptor (3)

Monoamine Transporter (3)

FAAH (3)

MAPK (3)

SARS-CoV (3)

Beta Amyloid (3)

STAT (3)

Anti-infection (3)

Thrombin (3)

Imidazoline Receptor (3)

Adenylyl cyclase (2)

EBI2/GPR183 (2)

Estrogen/progestogen Receptor (2)

Antioxidant (2)

Reductase (2)

DYRK (2)

MRP (2)

HBV (2)

PARP (2)

Cysteine Protease (2)

Topoisomerase (2)

LDL (2)

PAK (2)

HSV (2)

MMP (2)

TGF-beta/Smad (2)

transporter (2)

AMPK (2)

Hydroxylase (2)

HIF (2)

Platelet aggregation (2)

Syk (2)

Microtubule Associated (2)

Proteasome (1)

Carbonic Anhydrase (1)

ROR (1)

Integrin (1)

Dehydrogenase (1)

YAP (1)

Na+/Ca2+ Exchanger (1)

Neuropeptide W (1)

RAR/RXR (1)

NADPH (1)

PERK (1)

JNK (1)

Progesterone Receptor (1)

GSK-3 (1)

OCT (1)

c-Myc (1)

Estrogen Receptor/ERR (1)

Wnt/beta-catenin (1)

Serine Protease (1)

Antifolate (1)

Nucleoside Antimetabolite/Analog (1)

Amylase (1)

IAP (1)

FLAP (1)

GlyT (1)

Glucosidase (1)

Mitochondrial Metabolism (1)

BCL (1)

HCN Channel (1)

Stearoyl-CoA Desaturase (SCD) (1)

Angiotensin-converting Enzyme (ACE) (1)

PTEN (1)

PAD (1)

Aurora Kinase (1)

Epigenetic Reader Domain (1)

DNA (1)

Androgen Receptor (1)

Interleukin (1)

ATP Citrate Lyase (1)

PGE Synthase (1)

MRGPR (1)

LRRK2 (1)

Trk receptor (1)

Free radical scavengers (1)

Casein Kinase (1)

RSV (1)

IκB/IKK (1)

GST (1)

GPX (1)

Reverse Transcriptase (1)

Retinoid Receptor (1)

CRISPR/Cas9 (1)

RXFP receptor (1)

Adenosine deaminase (1)

MEK (1)

FGFR (1)

Gap Junction Protein (1)

FLT (1)

NOD (1)

NADPH-oxidase (1)

Tyrosinase (1)

lysosomal autophagy (1)

HIF/HIF Prolyl-Hydroxylase (1)

FAK (1)

AhR (1)

PD-1/PD-L1 (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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