FDA 上市激酶抑制剂库

FDA-Approved Kinase Inhibitor Library

产品编号： L1610

激酶是一类从高能供体分子（如ATP）转移磷酸基团到特定靶分子的酶，这一过程被称为磷酸化。比较常见的激酶族群是蛋白激酶，蛋白激酶作用于特定的蛋白质，使其磷酸化而改变其活性。蛋白激酶参与了一系列细胞信号传导和调节过程，在细胞生长、代谢、分化和凋亡中发挥重要作用。蛋白激酶与许多疾病有关，包括癌症、炎性疾病、心血管疾病和神经疾病等。因此，靶向蛋白激酶已成为治疗相关疾病的一种有潜力的治疗策略。

TargetMol FDA 上市激酶库包含263 个靶向激酶的上市药物，这些激酶包括：Insulin/IGF Receptors、PI 3-Kinase、CaM Kinase II、JAK、PKA、CDK、JNK、PKC、CKI II、MAPK、RAF、EGFR、MEK、SAPK、GSK、MLCK、Src-family、IKK、PDGFR、VEGFR 等。是激酶药物开发及相关研究的有用工具。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

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Product Description

263种靶向激酶的上市药物集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；
所有化合物都经过了严格的临床前研究和临床试验，由FDA、EMA、PMDA等批准上市，生物活性和安全性已经得到验证。
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Autophagy (72)

Apoptosis (57)

EGFR (35)

VEGFR (33)

c-Kit (32)

PDGFR (30)

JAK (18)

FGFR (18)

FLT (18)

Src (16)

Bcr-Abl (16)

c-Met/HGFR (14)

Tyrosine Kinases (14)

PKC (12)

CDK (12)

Raf (12)

ALK (11)

Mitophagy (10)

Antibacterial (10)

NF-κB (10)

PI3K (9)

Endogenous Metabolite (9)

AMPK (9)

c-RET (9)

Adrenergic Receptor (8)

BTK (8)

CaMK (8)

mTOR (8)

Sodium Channel (8)

Antibiotic (8)

Ferroptosis (7)

PKA (7)

Trk receptor (7)

5-HT Receptor (7)

MEK (7)

TAM Receptor (7)

Calcium Channel (6)

ERK (6)

ROCK (6)

Potassium Channel (6)

HER (6)

HIV Protease (5)

Histamine Receptor (5)

Parasite (5)

PDE (5)

ROS (5)

COX (5)

Akt (5)

AChR (5)

Ras (5)

ROS Kinase (5)

Dopamine Receptor (4)

p38 MAPK (4)

Antifungal (4)

GSK-3 (4)

Serine/threonin kinase (4)

Influenza Virus (4)

IκB/IKK (4)

Topoisomerase (3)

Glucosidase (3)

PAK (3)

IGF-1R (3)

SARS-CoV (3)

c-Fms (3)

P450 (3)

Syk (3)

FAK (3)

ROR (2)

Ligands for Target Protein for PROTAC (2)

LPL Receptor (2)

Adenosine Receptor (2)

NADPH (2)

Glutathione Peroxidase (2)

TOPK (2)

Phosphatase (2)

Serine Protease (2)

Serotonin Transporter (2)

IRE1 (2)

Hexokinase (2)

Aurora Kinase (2)

Lipoxygenase (2)

Interleukin (2)

DNA/RNA Synthesis (2)

MAPK (2)

P-gp (2)

Ephrin Receptor (2)

Nrf2 (2)

TNF (2)

Microtubule Associated (2)

Tyrosinase (2)

S1P Receptor (2)

PKM (2)

Chloride channel (1)

Proton pump (1)

Transferase (1)

DHFR (1)

DNA-PK (1)

HCV Protease (1)

Integrin (1)

Estrogen/progestogen Receptor (1)

Dehydrogenase (1)

YAP (1)

Antioxidant (1)

IFNAR (1)

JNK (1)

gp120/CD4 (1)

Virus Protease (1)

Melatonin Receptor (1)

HBV (1)

PPAR (1)

Hck (1)

Antifolate (1)

Nucleoside Antimetabolite/Analog (1)

Caspase (1)

TRP/TRPV Channel (1)

CSF-1R (1)

LDL (1)

GRK (1)

Phosphorylase (1)

Mitochondrial Metabolism (1)

Monoamine Transporter (1)

Reactive Oxygen Species (1)

HSV (1)

IL Receptor (1)

Chk (1)

PAD (1)

ACK (1)

GluR (1)

Norepinephrine (1)

DNA (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

TGF-beta/Smad (1)

ATP Citrate Lyase (1)

AChE (1)

Antiviral (1)

Sirtuin (1)

Beta Amyloid (1)

HDAC (1)

Hydroxylase (1)

PLK (1)

Gap Junction Protein (1)

Anti-infection (1)

NADPH-oxidase (1)

S6 Kinase (1)

Sigma receptor (1)

HIF/HIF Prolyl-Hydroxylase (1)

NO Synthase (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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