肝脏毒性化合物库

Drug-induced Liver Injury (DILI) Compound Library

产品编号： L5510

药物性肝损伤（drug-induced liver injury，DILI）是一种常见的药物不良反应，在药物性靶器官毒性中仅次于心脏毒性，是导致药物研发终止或从市场撤回的重要原因之一。因此，药物的肝脏毒性正日益受到医学界、社会公众和药监部门的广泛关注和重视。 DILI 已被证实是一个由多种机制参与的复杂病理过程，其中包括肝脏的结构和功能完整性的直接损害（例如线粒体功能障碍）；产生改变肝细胞结构和功能的代谢产物；产生能与肝蛋白结合的反应性药物代谢产物，从而产生新的抗原性药物-蛋白质加合物，这些新的加合物被宿主的防御系统所针对（半抗原假说），并引发损害肝脏的全身超敏反应（即药物过敏）。 TargetMol 肝脏毒性化合物库包含 1230 个能够引起肝损伤的化合物，这些化合物包括抗肿瘤药物、抗生素药物、抗精神疾病药物、心血管药物等，是开展 DILI 和相关药物毒理学研究的有力工具，对了解 DILI 发病机制，找到预测其发生、进展的生物标志物，以及有效防控 DILI 具有重要价值。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

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产品描述

1230个肝脏毒性化合物的特有集合，可用于高通量、高内涵筛选，是毒理学研究的良好工具；
包括抗肿瘤药物、抗生素药物、抗精神疾病药物、心血管药物等；
具有多样化的肝脏毒性，包括脂肪变性，线粒体毒性，胆汁淤积效应，超敏反应等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Autophagy (636)

Antibacterial (504)

Antibiotic (498)

Apoptosis (444)

5-HT Receptor (285)

Adrenergic Receptor (231)

Dopamine Receptor (201)

COX (186)

Histamine Receptor (177)

HIV Protease (168)

AChR (159)

DNA/RNA Synthesis (141)

Potassium Channel (138)

Parasite (123)

Calcium Channel (120)

Sodium Channel (111)

Endogenous Metabolite (105)

Ferroptosis (87)

Cytochromes P450 (87)

VEGFR (81)

Mitophagy (78)

Topoisomerase (78)

Antifungal (75)

SARS-CoV (75)

RAAS (72)

Serotonin Transporter (69)

PDE (63)

EGFR (63)

PDGFR (63)

GABA Receptor (63)

c-Kit (63)

Norepinephrine (57)

Dehydrogenase (54)

Influenza Virus (54)

ribosome (54)

PPAR (51)

Reverse Transcriptase (51)

Nucleoside Antimetabolite/Analog (48)

Microtubule Associated (48)

Estrogen/progestogen Receptor (42)

Reactive Oxygen Species (42)

HSV (42)

HCV Protease (39)

JAK (39)

FGFR (39)

FLT (39)

DNA Alkylator/Crosslinker (36)

MAO (36)

HMG-CoA Reductase (36)

Src (33)

Proteasome (33)

MRP (33)

Antifolate (30)

Bcr-Abl (30)

Raf (30)

HDAC (30)

c-Met/HGFR (27)

Phosphatase (27)

PI3K (27)

Factor Xa (27)

PARP (27)

Tyrosine Kinases (27)

MMP (27)

NF-κB (27)

c-RET (27)

Thrombin (27)

Proton pump (24)

Transferase (24)

Adenosine Receptor (24)

Virus Protease (24)

NMDAR (24)

Antifection (24)

ROS (24)

Opioid Receptor (24)

DPP-4 (24)

P-gp (24)

Cholinesterase (ChE) (24)

Androgen Receptor (24)

TNF (24)

Monoamine Oxidase (24)

Progesterone Receptor (21)

Glucocorticoid Receptor (21)

iGluR (21)

DNA gyrase (21)

CDK (21)

ALK (21)

HIF/HIF Prolyl-Hydroxylase (21)

Carbonic Anhydrase (18)

DHFR (18)

P2Y Receptor (18)

Estrogen Receptor/ERR (18)

TRP/TRPV Channel (18)

HBV (18)

ABC Transporter (18)

GluR (18)

CaMK (18)

mTOR (18)

Prostaglandin Receptor (18)

Phospholipase (18)

S1P Receptor (18)

Histone Methyltransferase (15)

LPL Receptor (15)

Thyroid hormone receptor(THR) (15)

ATPase (15)

PKC (15)

Guanylate cyclase (15)

DNA Alkylation (15)

Endothelin Receptor (15)

AMPK (15)

DNA Methyltransferase (15)

TAM Receptor (15)

HER (15)

ADC Cytotoxin (14)

NADPH (12)

Glutathione Peroxidase (12)

GNRH Receptor (12)

IL Receptor (12)

Lipoxygenase (12)

Interleukin (12)

HSP (12)

TLR (12)

Hedgehog/Smoothened (12)

Trk receptor (12)

Nrf2 (12)

STAT (12)

Neurokinin receptor (12)

ROS Kinase (12)

Chloride channel (9)

Reductase (9)

Melatonin Receptor (9)

Serine Protease (9)

Caspase (9)

UGT (9)

Mitochondrial Metabolism (9)

ERK (9)

Drug Metabolite (9)

Monoamine Transporter (9)

Fatty Acid Synthase (9)

Xanthine Oxidase (9)

Akt (9)

Free radical scavengers (9)

Bcl-2 Family (9)

Molecular Glues (9)

Isocitrate Dehydrogenase (IDH) (9)

CCR (9)

Antiviral (9)

MEK (9)

AhR (9)

Retinoid Receptor (9)

Ligand for E3 Ligase (9)

Aromatase (9)

Melanocortin Receptor (9)

Hydroxylase (9)

HIF (9)

MALT (6)

ROR (6)

Ligands for Target Protein for PROTAC (6)

Antioxidant (6)

Histone Demethylase (6)

CETP (6)

ROCK (6)

IRE1 (6)

LDL (6)

Leukotriene Receptor (6)

Gamma-secretase (6)

MT Receptor (6)

P2X Receptor (6)

Glucosidase (6)

Smo (6)

Epigenetic Reader Domain (6)

DNA (6)

Integrase (6)

PAK (6)

Telomerase (6)

OAT (6)

Ephrin Receptor (6)

Beta Amyloid (6)

c-Fms (6)

Protease-activated Receptor (6)

CFTR (6)

RSV (6)

GPR (6)

Adenosine Deaminase (6)

Ras (6)

Sigma receptor (6)

Imidazoline Receptor (6)

Kras (4)

Monocarboxylate transporter (3)

DNA-PK (3)

CRM1 (3)

Cell wall (3)

JNK (3)

NPC1L1 (3)

Hydrogenase (3)

Integrin (3)

p38 MAPK (3)

YAP (3)

LTR (3)

IFNAR (3)

VDA (3)

Wnt/beta-catenin (3)

Adiponectin Receptor (3)

Rho (3)

Cysteine Protease (3)

FXR (3)

Aryl Hydrocarbon Receptor (3)

CSF-1R (3)

Immunology/Inflammation related (3)

GRK (3)

GlyT (3)

BTK (3)

HCN Channel (3)

Vasopressin Receptor (3)

ACK1 (3)

CXCR (3)

Angiotensin-converting Enzyme (ACE) (3)

Chk (3)

cAMP (3)

Mucin (3)

TGF-beta/Smad (3)

ATP Citrate Lyase (3)

PGE Synthase (3)

Beta-Secretase (3)

Sirtuin (3)

Decarboxylase (3)

Epoxide Hydrolase (3)

IGF-1R (3)

MAPK (3)

Histone Acetyltransferase (3)

GluCls (3)

Pyroptosis (3)

IκB/IKK (3)

GST (3)

PDK (3)

CGRP Receptor (3)

NO Synthase (3)

CRISPR/Cas9 (3)

Aquaporin (3)

Gap Junction Protein (3)

Platelet aggregation (3)

Syk (3)

Anti-infection (3)

NOD (3)

NADPH-oxidase (3)

S6 Kinase (3)

Tyrosinase (3)

NOD-like Receptor (NLR) (3)

Vitamin (2)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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