细胞因子抑制剂库

Cytokine Inhibitor Library

产品编号： L3600

细胞因子是与维持免疫平衡相关的小分泌蛋白，与多种自身免疫和炎性疾病的发病机理有关。阻断细胞因子或其受体的生物制剂已经显著改善了这些病症的治疗方法，尽管如此，仍有一些患者对这些药物没有反应或者没有达到理想效果。

细胞因子通常与膜特异受体结合，激活相关信号途径，调控基因表达和细胞功能，例如白细胞介素，干扰素（IFN）和肿瘤坏死因子（TNF）等。转导细胞因子信号的常见途径有：JAK-STAT、NF-kB、MAPK、PI3K 等，随着研究的深入针对上述途径的小分子抑制剂越来越多，有些已经批准上市，我们精选了 815 个细胞因子相关化合物组成TargetMol 细胞因子抑制剂库，其靶点涉及多种不同功能的细胞因子，适用于高通量、高内涵筛选。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

815个与细胞因子紧密相关的化合物集合，是高通量、高内涵筛选的良好载体；
靶点涵盖不同功能的细胞因子，包括白细胞介素（IL）、集落刺激因子CSF（CSF）、干扰素（IFN）、肿瘤坏死因子（TNF）、转化生长因子-β家族（TGF-β family）、生长因子（GF）、趋化因子（chemokinefamily）；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

EGFR (178)

VEGFR (156)

PDGFR (90)

FGFR (79)

Apoptosis (64)

c-Kit (61)

TNF (49)

CCR (48)

Autophagy (47)

FLT (46)

TGF-beta/Smad (46)

IL Receptor (42)

CXCR (41)

Src (37)

IGF-1R (35)

c-Fms (28)

HER (28)

ALK (26)

c-Met/HGFR (26)

Bcr-Abl (22)

c-RET (19)

Interleukin (18)

Raf (17)

JAK (16)

CDK (14)

Aurora Kinase (13)

CSF-1R (13)

HIV Protease (12)

IFNAR (9)

TAM Receptor (9)

Tyrosine Kinases (9)

BTK (8)

Akt (7)

COX (7)

FAK (7)

MEK (7)

p38 MAPK (7)

Trk receptor (7)

IκB/IKK (6)

NF-κB (6)

PI3K (6)

ERK (5)

Ferroptosis (5)

MAPK (5)

mTOR (5)

PDE (5)

S6 Kinase (5)

AMPK (4)

Chk (4)

Drug Metabolite (4)

Ephrin Receptor (4)

Influenza Virus (4)

Ligand for E3 Ligase (4)

Mitophagy (4)

MLK (4)

Molecular Glues (4)

PKC (4)

Potassium Channel (4)

STAT (4)

Syk (4)

Tie-2 (4)

5-HT Receptor (3)

Antibacterial (3)

Antibiotic (3)

Antiviral (3)

Calcium Channel (3)

Caspase (3)

DNA/RNA Synthesis (3)

GSK-3 (3)

HCV Protease (3)

NOD (3)

NOD-like Receptor (NLR) (3)

PKA (3)

STING (3)

TLR (3)

Tyrosinase (3)

ADC Cytotoxin (2)

Antioxidant (2)

Casein Kinase (2)

Dehydrogenase (2)

Discoidin Domain Receptor (DDR) (2)

Endogenous Metabolite (2)

Glucocorticoid Receptor (2)

HDAC (2)

HIF/HIF Prolyl-Hydroxylase (2)

Integrin (2)

IRE1 (2)

JNK (2)

Mitochondrial Metabolism (2)

MyD88 (2)

PLK (2)

PYK2 (2)

RIP kinase (2)

SARS-CoV (2)

Sodium Channel (2)

AChE (1)

Adrenergic Receptor (1)

AIM2 (1)

Annexin A (1)

Apelin receptor (1)

Arrestin (1)

Beta Amyloid (1)

CaMK (1)

Complement System (1)

DNA Alkylation (1)

DNA-PK (1)

E1/E2/E3 Enzyme (1)

Epigenetic Reader Domain (1)

Estrogen Receptor/ERR (1)

Estrogen/progestogen Receptor (1)

Gap Junction Protein (1)

GluR (1)

Glutathione Peroxidase (1)

GPR (1)

GTPase (1)

HBV (1)

Hck (1)

HIF (1)

Hippo pathway (1)

Histamine Receptor (1)

Histone Acetyltransferase (1)

Immunology/Inflammation related (1)

IRAK (1)

LDL (1)

Leukotriene Receptor (1)

Lipase (1)

LRRK2 (1)

LTR (1)

MAO (1)

Microtubule Associated (1)

NADPH (1)

NAMPT (1)

NOS (1)

P450 (1)

PAI-1 (1)

Parasite (1)

PDK (1)

P-gp (1)

Phosphatase (1)

Phospholipase (1)

Progesterone Receptor (1)

Proteasome (1)

Pyroptosis (1)

Reactive Oxygen Species (1)

Reverse Transcriptase (1)

ROCK (1)

ROR (1)

ROS (1)

ROS Kinase (1)

RSV (1)

Serine Protease (1)

SGK (1)

Sirtuin (1)

TRP/TRPV Channel (1)

VDA (1)

Virus Protease (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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