铜死亡化合物库

Cuproptosis Compound Library

产品编号： L8710

铜离子是所有生物必不可少的辅助因子，但当其浓度超过一定阈值时，就会对机体产生毒害作用。铜死亡的发生机制明显区别于已知的细胞凋亡、焦亡、坏死及铁死亡的细胞死亡方式：铜离子通过直接结合三羧酸（TCA）循环途径中的脂酰化成分，导致脂酰化蛋白异常聚集以及铁硫簇蛋白的丢失，从而导致蛋白质毒性应激反应并导致细胞死亡。铜死亡与肌萎缩侧索硬化症（ALS）、乳腺癌、黑色素瘤、成神经细胞瘤、和前列腺癌等疾病有关。 TargetMol 铜死亡化合物库集合了 400 种与铜死亡相关的化合物，可以用于铜死亡机制及相关疾病研究

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

400 种与铜死亡相关的活性小分子，可用于高通量和高内涵筛选；
靶向FDX1，胞浆金属伴侣(ATOX1)，CCS (copper chaperones)，线粒体呼吸等；
部分化合物已被FDA批准上市；
详细的说明书，化合物结构、靶点信息、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Reactive Oxygen Species (153)

Autophagy (100)

Apoptosis (99)

BCL (58)

Endogenous Metabolite (55)

Mitophagy (52)

ROS (51)

Mitochondrial Metabolism (49)

Antibacterial (30)

COX (19)

NF-κB (17)

Ferroptosis (16)

HIV Protease (15)

Antioxidant (13)

PDE (13)

Antifungal (12)

Caspase (12)

IAP (12)

Antibiotic (12)

Parasite (11)

HSP (10)

Influenza Virus (10)

Dehydrogenase (8)

Topoisomerase (8)

IL Receptor (8)

ROS Kinase (8)

PKM (8)

Calcium Channel (7)

HIF/HIF Prolyl-Hydroxylase (7)

NO Synthase (7)

ATPase (6)

p38 MAPK (6)

Estrogen/progestogen Receptor (6)

PARP (6)

ALK (6)

HDAC (6)

P450 (6)

TNF (6)

PI3K (5)

PPAR (5)

MMP (5)

Xanthine Oxidase (5)

Akt (5)

Nrf2 (5)

AMPK (5)

GABA Receptor (5)

p53 (5)

NOS (4)

c-Met/HGFR (4)

NADPH (4)

Virus Protease (4)

PKC (4)

E1/E2/E3 Enzyme (4)

DNA/RNA Synthesis (4)

Histamine Receptor (3)

JNK (3)

Wnt/beta-catenin (3)

VEGFR (3)

ERK (3)

Gamma-secretase (3)

JAK (3)

HSV (3)

Lipoxygenase (3)

mTOR (3)

P-gp (3)

Trk receptor (3)

IκB/IKK (3)

5-HT Receptor (3)

Potassium Channel (3)

FLT (3)

Sodium Channel (3)

Microtubule Associated (3)

Chloride channel (2)

Monocarboxylate transporter (2)

ROR (2)

HCV Protease (2)

Dynamin (2)

RAAS (2)

HBV (2)

Estrogen Receptor/ERR (2)

Tyrosine Kinases (2)

Cysteine Protease (2)

Adrenergic Receptor (2)

MAO (2)

IRE1 (2)

Opioid Receptor (2)

PDGFR (2)

Epigenetic Reader Domain (2)

IGF-1R (2)

Interleukin (2)

OXPHOS (2)

TLR (2)

SARS-CoV (2)

Beta Amyloid (2)

Reverse Transcriptase (2)

STAT (2)

PDK (2)

Phospholipase (2)

AChR (2)

c-Kit (2)

Anti-infection (2)

HMG-CoA Reductase (2)

CFTR (2)

Proteasome (1)

Mdm2 (1)

CAT (1)

Carbonic Anhydrase (1)

Src (1)

MyD88 (1)

Ligands for Target Protein for PROTAC (1)

YAP (1)

Adenosine Receptor (1)

IFNAR (1)

aconitase (1)

RAR/RXR (1)

Histone Demethylase (1)

Glutathione Peroxidase (1)

Phosphatase (1)

Melatonin Receptor (1)

PKA (1)

FXR (1)

TRP/TRPV Channel (1)

Amylase (1)

Glucocorticoid Receptor (1)

Immunology/Inflammation related (1)

Annexin A (1)

UGT (1)

CDK (1)

Drug Metabolite (1)

Phosphorylase (1)

NMDAR (1)

Hexokinase (1)

Hedgehog/Smoothened (1)

FAAH (1)

Somatostatin (1)

GluR (1)

cAMP (1)

CaMK (1)

DNA (1)

Androgen Receptor (1)

TGF-beta/Smad (1)

SGLT (1)

Glutathione reductase (1)

AChE (1)

Antiviral (1)

Prostaglandin Receptor (1)

STING (1)

LRRK2 (1)

Aminopeptidase (1)

Free radical scavengers (1)

Sirtuin (1)

Histone Acetyltransferase (1)

RSV (1)

Casein Kinase (1)

ATM/ATR (1)

GST (1)

Retinoid Receptor (1)

Aromatase (1)

CRISPR/Cas9 (1)

GPR (1)

HIF (1)

MEK (1)

FGFR (1)

Discoidin Domain Receptor (DDR) (1)

Platelet aggregation (1)

Syk (1)

NOD (1)

NADPH-oxidase (1)

IRAK (1)

S6 Kinase (1)

Tyrosinase (1)

Thrombin (1)

NOD-like Receptor (NLR) (1)

AhR (1)

Monoamine Oxidase (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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