血脑屏障通透化合物库

CNS-Penetrant Compound Library

产品编号： L5900

血脑屏障是由毛细血管内皮细胞及其之间的紧密链接组成，保护大脑免受外界异质物质的破坏，限制物质分子扩散进入中枢神经系统，由于血脑屏障的阻碍作用，脑肿瘤等疾病的化疗功效也受到很大影响。因此治疗大多数脑疾病的主要挑战是将治疗药物穿过血脑屏障递送到大脑的特定区域，在针对 CNS 靶标筛选库的设计中选择能够穿透血脑屏障的分子，对于整个 CNS 药物发现过程起着至关重要的作用。

我们精心挑选了 660 个血脑屏障通透性化合物，有明确作用靶点、生物活性验证有效，用于 CNS-Penetrant 相关的研究及中枢神经系统疾病药物的筛选，可用于高通量、高内涵筛选。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

660 个CNS-Penetrant生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
靶点包括激酶、GPCR和离子通道等；
是脑肿瘤、精神障碍和神经退行性疾病等脑疾病药物筛选的有效工具；
结构多样，药效显著，可渗透血脑屏障和细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

化合物库定制

我们的化合物库可以灵活定制！了解更多

化合物库咨询

化合物库组成

5-HT Receptor (77)

Dopamine Receptor (66)

Autophagy (59)

Antibacterial (48)

Antibiotic (45)

Apoptosis (42)

Endogenous Metabolite (40)

AChR (37)

Adrenergic Receptor (36)

Histamine Receptor (33)

Glucocorticoid Receptor (33)

GABA Receptor (29)

Calcium Channel (20)

COX (19)

Serotonin Transporter (16)

Potassium Channel (16)

Sodium Channel (16)

Monoamine Oxidase (16)

MAO (15)

Parasite (14)

DNA/RNA Synthesis (14)

HIV Protease (13)

GluR (13)

AChE (11)

iGluR (10)

Norepinephrine (10)

Antifungal (9)

NMDAR (9)

P450 (9)

Mitophagy (8)

PDE (8)

Reactive Oxygen Species (8)

Nucleoside Antimetabolite/Analog (7)

Beta Amyloid (7)

HDAC (7)

NF-κB (7)

Carbonic Anhydrase (6)

ADC Cytotoxin (6)

Ferroptosis (6)

Adenosine Receptor (6)

VEGFR (6)

Topoisomerase (6)

Antifection (6)

HSV (6)

Influenza Virus (6)

Reverse Transcriptase (6)

Dehydrogenase (5)

DNA Alkylator/Crosslinker (5)

PDGFR (5)

DNA Alkylation (5)

P-gp (5)

Prostaglandin Receptor (5)

Transferase (4)

PI3K (4)

Virus Protease (4)

TRP/TRPV Channel (4)

Opioid Receptor (4)

Interleukin (4)

EGFR (4)

AMPK (4)

MEK (4)

Neurokinin receptor (4)

c-Kit (4)

HMG-CoA Reductase (4)

Proteasome (3)

DHFR (3)

Src (3)

HCV Protease (3)

Amino Acids and Derivatives (3)

Estrogen/progestogen Receptor (3)

Antioxidant (3)

Phosphatase (3)

MRP (3)

PPAR (3)

PARP (3)

Antifolate (3)

Annexin A (3)

Gamma-secretase (3)

CDK (3)

Mitochondrial Metabolism (3)

ROS (3)

MMP (3)

Epigenetic Reader Domain (3)

CaMK (3)

mTOR (3)

SARS-CoV (3)

GPR (3)

Phospholipase (3)

Hydroxylase (3)

FGFR (3)

FLT (3)

HIF/HIF Prolyl-Hydroxylase (3)

DNA-PK (2)

Histone Methyltransferase (2)

p38 MAPK (2)

c-Met/HGFR (2)

Histone Demethylase (2)

NADPH (2)

Lipase (2)

RAAS (2)

JNK (2)

GSK-3 (2)

Tyrosine Kinases (2)

Cysteine Protease (2)

Vitamin (2)

Caspase (2)

PKC (2)

ROCK (2)

ERK (2)

CSF-1R (2)

Raf (2)

MT Receptor (2)

BTK (2)

Smo (2)

BCL (2)

IL Receptor (2)

Aurora Kinase (2)

HSP (2)

LRRK2 (2)

Retinoid Receptor (2)

STAT (2)

ribosome (2)

Adenosine deaminase (2)

TNF (2)

Cannabinoid Receptor (2)

Sigma receptor (2)

Microtubule Associated (2)

NOD-like Receptor (NLR) (2)

Imidazoline Receptor (2)

HER (2)

Melanin-concentrating Hormone Receptor (MCHR) (1)

Thyroid hormone receptor(THR) (1)

advanced glycation end products (1)

Chloride channel (1)

ATPase (1)

Proton pump (1)

NOS (1)

CAT (1)

Hydrogenase (1)

MALT (1)

Arginase (1)

Reductase (1)

BACE (1)

Arrestin (1)

Cell wall (1)

Glutathione Peroxidase (1)

Progesterone Receptor (1)

Melatonin Receptor (1)

ABC (1)

PKA (1)

Estrogen Receptor/ERR (1)

Wnt/beta-catenin (1)

Rho (1)

Serine/threonin kinase (1)

Liver X Receptor (1)

Neurotensin Receptor (1)

Immunology/Inflammation related (1)

IDO (1)

IRE1 (1)

UGT (1)

Bcr-Abl (1)

Drug Metabolite (1)

P2X Receptor (1)

GlyT (1)

Monoamine Transporter (1)

Molecular Glues (1)

Isocitrate Dehydrogenase (IDH) (1)

MAGL (1)

Fatty Acid Synthase (1)

JAK (1)

FAAH (1)

Endothelin Receptor (1)

OX Receptor (1)

Xanthine Oxidase (1)

Epoxide Hydrolase (1)

Lipoxygenase (1)

IGF-1R (1)

DNA (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Telomerase (1)

Lipid (1)

BCRP (1)

Akt (1)

Beta-Secretase (1)

PGE Synthase (1)

Acyltransferase (1)

Antiviral (1)

TLR (1)

Trk receptor (1)

Free radical scavengers (1)

Histone Acetyltransferase (1)

Nrf2 (1)

Pyroptosis (1)

IκB/IKK (1)

Neprilysin (1)

GST (1)

ATM/ATR (1)

c-Fms (1)

Ligand for E3 Ligase (1)

Aromatase (1)

CRISPR/Cas9 (1)

HIF (1)

RXFP receptor (1)

c-RET (1)

SGK (1)

Complement System (1)

Platelet aggregation (1)

Syk (1)

Anti-infection (1)

DNA Methyltransferase (1)

NOD (1)

S6 Kinase (1)

Ras (1)

TAM Receptor (1)

Thrombin (1)

FAK (1)

AhR (1)

CFTR (1)

MLK (1)

PD-1/PD-L1 (1)

NO Synthase (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

注册成功