血脑屏障通透化合物库

CNS-Penetrant Compound Library

产品编号： L5900

血脑屏障是由毛细血管内皮细胞及其之间的紧密链接组成，保护大脑免受外界异质物质的破坏，限制物质分子扩散进入中枢神经系统，由于血脑屏障的阻碍作用，脑肿瘤等疾病的化疗功效也受到很大影响。因此治疗大多数脑疾病的主要挑战是将治疗药物穿过血脑屏障递送到大脑的特定区域，在针对 CNS 靶标筛选库的设计中选择能够穿透血脑屏障的分子，对于整个 CNS 药物发现过程起着至关重要的作用。

基于相关文献报道及如下五个原则：（1）化学结构上亲脂性好，亲水性弱；（2）和血浆蛋白的结合弱；（3）分子量不宜过大；（4）已经证实的可以通过血脑屏障起作用的上市药物和临床药物；（5）和 CNS 相关靶点对应的小分子，我们精心挑选了 509 个化合物，这些化合物都可以穿过血脑屏障、有明确作用靶点、生物活性验证有效，用于 CNS-Penetrant 相关的研究及中枢神经系统疾病药物的筛选，可用于高通量、高内涵筛选。

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技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

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产品描述

509 个CNS-Penetrant生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
靶点包括激酶、GPCR和离子通道等；
是脑肿瘤、精神障碍和神经退行性疾病等脑疾病药物筛选的有效工具；
结构多样，药效显著，可渗透血脑屏障和细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Autophagy (107)

Apoptosis (86)

5-HT Receptor (53)

Dopamine Receptor (40)

Antibacterial (40)

Antibiotic (37)

AChR (32)

Endogenous Metabolite (31)

HIV Protease (27)

Adrenergic Receptor (25)

COX (23)

Sodium Channel (23)

Histamine Receptor (22)

Mitophagy (18)

GABA Receptor (18)

Calcium Channel (16)

Serotonin Transporter (14)

EGFR (14)

DNA/RNA Synthesis (14)

iGluR (12)

Potassium Channel (12)

PI3K (11)

VEGFR (11)

Norepinephrine (11)

Reverse Transcriptase (11)

NF-κB (11)

c-Kit (11)

Ferroptosis (10)

Antifungal (10)

Parasite (10)

HDAC (10)

CDK (9)

Reactive Oxygen Species (9)

PDGFR (9)

GluR (9)

AChE (9)

mTOR (8)

Influenza Virus (8)

FLT (8)

Estrogen/progestogen Receptor (7)

Dehydrogenase (7)

Bcr-Abl (7)

Beta Amyloid (7)

MEK (7)

DNA Alkylator/Crosslinker (6)

Virus Protease (6)

Nucleoside Antimetabolite/Analog (6)

TRP/TRPV Channel (6)

Topoisomerase (6)

PDE (6)

Raf (6)

NMDAR (6)

Antifection (6)

P-gp (6)

SARS-CoV (6)

c-Fms (6)

Monoamine Oxidase (6)

Src (5)

LPL Receptor (5)

Adenosine Receptor (5)

MAO (5)

CSF-1R (5)

Glucocorticoid Receptor (5)

P450 (5)

TNF (5)

Microtubule Associated (5)

NOD-like Receptor (NLR) (5)

S1P Receptor (5)

Transferase (4)

p38 MAPK (4)

Estrogen Receptor/ERR (4)

Antifolate (4)

ERK (4)

Drug Metabolite (4)

DNA Alkylation (4)

HSV (4)

MMP (4)

LRRK2 (4)

FGFR (4)

Proton pump (3)

Carbonic Anhydrase (3)

HCV Protease (3)

ABC (3)

Tyrosine Kinases (3)

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Molecular Glues (3)

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Epigenetic Reader Domain (3)

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Interleukin (3)

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ALK (3)

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Proteasome (2)

advanced glycation end products (2)

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Ligands for Target Protein for PROTAC (2)

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HBV (2)

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Akt (2)

HSP (2)

Prostaglandin Receptor (2)

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Sirtuin (2)

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IκB/IKK (2)

Retinoid Receptor (2)

STAT (2)

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GPR (2)

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NOD (2)

HMG-CoA Reductase (2)

S6 Kinase (2)

HIF/HIF Prolyl-Hydroxylase (2)

CFTR (2)

PD-1/PD-L1 (2)

Mdm2 (1)

Hydrogenase (1)

Integrin (1)

c-Met/HGFR (1)

Antioxidant (1)

BACE (1)

Arrestin (1)

NADPH (1)

Histone Demethylase (1)

Lipase (1)

JNK (1)

Glutathione Peroxidase (1)

GSK-3 (1)

Wnt/beta-catenin (1)

Cysteine Protease (1)

Liver X Receptor (1)

Caspase (1)

PKC (1)

IRE1 (1)

Annexin A (1)

E1/E2/E3 Enzyme (1)

LDL (1)

MT Receptor (1)

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GlyT (1)

ROS (1)

Fatty Acid Synthase (1)

JAK (1)

CCR (1)

Chk (1)

Epoxide Hydrolase (1)

Aurora Kinase (1)

Lipoxygenase (1)

IGF-1R (1)

DUB (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Telomerase (1)

Lipid (1)

BCRP (1)

Beta-Secretase (1)

MAPK (1)

Antiviral (1)

Free radical scavengers (1)

Histone Acetyltransferase (1)

Nrf2 (1)

Pyroptosis (1)

RSV (1)

GST (1)

Aromatase (1)

PDK (1)

Hydroxylase (1)

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HIF (1)

SGK (1)

Complement System (1)

Cannabinoid Receptor (1)

Syk (1)

DNA Methyltransferase (1)

Ras (1)

Sigma receptor (1)

Tyrosinase (1)

AhR (1)

MLK (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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